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Medicine for assisting in treating breast cancer and preparation method of medicine

A technology for adjuvant therapy and breast cancer, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of triple-negative breast cancer treatment, complex anti-cancer treatment measures, and unstable clinical symptoms. Achieve the effects of eliminating or inhibiting tumor development, regulating the body's immune mechanism, and overcoming drug resistance

Inactive Publication Date: 2018-01-05
NANJING XIANCAOTANG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of this acquired drug resistance has led to more complex anti-cancer treatment measures, posing new challenges to clinical anti-cancer treatment, especially for the treatment of triple-negative breast cancer.
[0004] At present, Western medical methods such as surgery, chemotherapy, radiotherapy and other methods are used to treat advanced patients, which are prone to drug resistance, and the clinical symptoms are unstable, and the side effects of radiotherapy and chemotherapy are accumulated, which will affect the survival of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Example 1: A drug for adjuvant treatment of breast cancer and its preparation method

[0079] A medicine for adjuvant treatment of breast cancer. In parts by weight, the raw material formula of the medicine comprises: 25 parts of centipede extract, 12 parts of angelica, 18 parts of Prunella vulgaris, 12 parts of Mutong, 11 parts of red bean, and 8 parts of Codonopsis pilosula 7 parts of licorice, 6 parts of rhubarb, 8 parts of astragalus, 9 parts of ginseng, 7 parts of black nightshade, and 6 parts of oolong tea.

[0080] The preparation method comprises the following steps:

[0081] (1) Take fresh and live adults of centipede, quickly place them in a liquid nitrogen tank, freeze them with liquid nitrogen for 20 minutes, take them out and grind them into powder, pour the powder into a centrifuge tube, add Tris-HCl buffer solution, 0.01 times the volume (relative to Volume of powder) proteinase K aqueous solution, 52 ° C for 5 minutes. The concentration of the proteina...

Embodiment 2

[0088] Example 2: A drug for adjuvant treatment of breast cancer and its preparation method

[0089] A medicine for adjuvant treatment of breast cancer. In parts by weight, the raw material formula of the medicine comprises: 45 parts of centipede extract, 30 parts of angelica, 22 parts of Prunella vulgaris, 21 parts of Mutong, 22 parts of red bean, 13 parts of Codonopsis pilosula 18 parts of licorice, 16 parts of rhubarb, 15 parts of astragalus, 17 parts of ginseng, 15 parts of black nightshade, and 14 parts of oolong tea.

[0090] The preparation method comprises the following steps:

[0091] (1) Take fresh and live adults of centipede, quickly place them in a liquid nitrogen tank, freeze them with liquid nitrogen for 32 minutes, take them out and grind them into powder, pour the powder into a centrifuge tube, add Tris-HCl buffer solution, 0.03 times the volume (relative to Volume of powder) proteinase K aqueous solution, 56 ° C for 12 minutes. The concentration of the prot...

Embodiment 3

[0098] Example 3: A drug for adjuvant treatment of breast cancer and its preparation method

[0099] A medicine for adjuvant treatment of breast cancer. In parts by weight, the raw material formula of the medicine comprises: 60 parts of centipede extract, 35 parts of angelica, 29 parts of Prunella vulgaris, 30 parts of Akebia, 28 parts of red bean, 19 parts of Codonopsis pilosula 22 parts of licorice, 21 parts of rhubarb, 22 parts of astragalus, 23 parts of ginseng, 20 parts of black nightshade, and 19 parts of oolong tea.

[0100] The preparation method comprises the following steps:

[0101] (1) Take fresh and live adults of centipede, quickly place them in a liquid nitrogen tank, freeze them with liquid nitrogen for 40 minutes, take them out and grind them into powder, pour the powder into a centrifuge tube, add Tris-HCl buffer, 0.05 times the volume (relative to Volume of powder) proteinase K aqueous solution, 58 ℃ for 15 minutes. The concentration of the proteinase K aq...

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PUM

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Abstract

The invention discloses a medicine for assisting in treating a breast cancer and a preparation method of the medicine. The medicine comprises the following raw materials in parts by weight: 25-60 parts of centipede extract, 12-35 parts of angelica sinensis, 18-29 parts of selfheal, 12-30 parts of akebiaquinata, 11-28 parts of ormosia, 8-19 parts of codonopsis pilosula, 7-22 parts of glycyrrhiza uralensis, 6-21 parts of rhubarb, 8-22 parts of astragalus mongholicus, 9-23 parts of ginseng, 7-20 parts of nightshade and 6-19 parts of oolong tea. The prepared medicine for assisting in treating thebreast cancer can assist in western medicine treatment of the breast cancer, particularly can effectively eliminate or inhibit tumor development for late-stage patients incapable of undergoing surgery, chemotherapy and radiotherapy, improves clinical symptoms of the patients, reduces toxic and side effects of the chemotherapy and the radiotherapy, overcomes multidrug resistance of tumor cells, regulates immunologic mechanisms of bodies, improves curative effects of the surgery, the chemotherapy and the radiotherapy, improves the life quality of the patients, and prolongs the life time.

Description

technical field [0001] The invention relates to a Chinese patent medicine, in particular to a medicine for adjuvant treatment of breast cancer and a preparation method thereof, belonging to the field of medicinal chemistry. Background technique [0002] Breast cancer is a major malignant tumor that threatens women's health. Its incidence rate ranks first among female malignant tumors in European and American countries. There are more than 1 million new cases every year in the world, and the incidence rate is increasing at a rate of 1% to 2% per year. my country originally belonged to an area with a low incidence of breast cancer, but in recent years, in Beijing, Shanghai and other big cities, breast cancer has also rapidly risen to the first place in the incidence of female malignant tumors. According to statistics, it accounts for 7% to 10% of all kinds of malignant tumors in the whole body. %. [0003] With the rapid development of molecular biology and the continuous emer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P35/00A61K35/648
Inventor 史月龙曾宋君吴英亮刘文斌吴坤林汤静
Owner NANJING XIANCAOTANG BIOLOGICAL TECH CO LTD
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