232results about How to "Undesirable effect" patented technology

The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNFα activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNFα antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNFα activity, such as psoriasis.

A method for improving the useful life of a thin film lithium-ion battery containing a solid electrolyte and an anode that expands on charging and long life batteries made by the method. The method includes providing a hermetic barrier package for the thin film battery that includes an anode expansion absorbing structure and at least one film getter.

The present invention is a hybrid technique for finding defects on digitized device images using a combination of spatial domain and frequency domain techniques. The two dimensional spectra of two images are found using Fourier like transforms. Any strong harmonics in the spectra are removed, using the same spectral filter on both spectra. The images are then aligned, transformed back to the spatial domain, and subtracted. The resulting spectrally-filtered difference image is thresholded and analyzed for defects. Use of the hybrid technique of the present invention to process digitized images results in the highest-performance and most flexible defect detection system. It is the best performer on both array and random devices, and it can cope with problems such as shading variations and the dark-bright problem that no other technique can address. The hybrid technique of the present invention also uses frequency domain techniques to align the images with fewer errors than spatial domain techniques of similar or lesser complexity. Further, the relative offsets of the pairs of images are determined by frequency domain techniques--and this method may be the most accurate and the least expensive.

A z-axis gyroscope design is presented with a 2-degree of freedom (DOF) sense mode allowing interchangeable operation in either precision (mode-matched) or robust (wide-bandwidth) modes. This is accomplished using a complete 2-DOF coupled system which allows for the specification of the sense mode resonant frequencies and coupling independent of frequency. By decoupling the frame connecting the sense system to a central anchor, x-y symmetry is preserved while enabling a fully coupled 2-DOF sense mode providing control over both the bandwidth and the amount of coupling independent of operational frequency. The robust mode corresponds to operation between the 2-DOF sense mode resonant frequencies providing a response gain and bandwidth controlled by frequency spacing. Precision mode of operation, however, relies on mode-matching the drive to the second, anti-phase sense mode resonant frequency which can be designed to provide a gain advantage over a similar 1-DOF system.

An ophthalmic pharmaceutical composition useful in the treatment of glaucoma and control of intraocular pressure comprising an effective amount of a selective modulator of ALK5 receptor activity is disclosed. Also disclosed is a method of treating glaucoma and controlling intraocular pressure comprising applying a therapeutically effective amount of a pharmaceutical composition comprising a selective modulator of ALK5 receptor activity to an affected eye of a patient.

An expandable intragastric balloon comprising a first flexible pouch (2) comprising a port; a second pouch (20) which contains the first pouch (2) and which is equipped with a hole (21); and, a sealing member (4) which is hermetically fixed to the second pouch (20) and which is intended to seal the port and the hole (21). The first and second pouches (2, 20) are produced from different, non-compatible materials and are assembled with the aid of a fixing element (7). The fixing element is designed to ensure that the sealing member (4) is hermetically fixed to the first pouch (2) inside a passage (6) that is defined by a neck (5) which extends from the port, such that sufficient pressure is exerted on the neck (5) in order for same to be pinched between the sealing member (4) and the fixing element (7).

The present invention provides a surgical system 10 for aspiration of a biological material comprising a source of irrigation fluid 24, a collection cassette 30, a pump 40 for creating a vacuum in the collection cassette 30, a handpiece 50 applied to a surgical area for infusing irrigation fluid and for aspirating a biological material, conduits 60 and 62 connecting the handpiece to each of the source of irrigation fluid and the collection cassette and means 70 for isolating the pump from the handpiece to prevent creation of vacuum within the conduit 62 and the collection cassette 30 after receiving a stop signal.

The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties, including increased biomass or improved cold or other osmotic stress tolerance, as compared to wild-type or reference plants. The invention also pertains to expression systems that may be used to regulate these transcription factor polynucleotides, providing constitutive, transient, inducible and tissue-specific regulation.

An optical parametric oscillator (OPO) is described that efficiently converts a near-infrared laser beam to tunable mid-infrared wavelength output. In some embodiments, the OPO includes an optical resonator containing a nonlinear crystal, such as periodically-poled lithium niobate. The OPO is pumped by a continuous-wave fiber-laser source having a low-power oscillator and a high-power amplifier, or using just a power oscillator). The fiber oscillator produces a single-frequency output defined by a distributed-feedback (DFB) structure of the fiber. The DFB-fiber-laser output is amplified to a pump level consistent with exceeding an oscillation threshold in the OPO in which only one of two generated waves (“signal” and “idler”) is resonant within the optical cavity. This pump source provides the capability to tune the DFB fiber laser by straining the fiber (using an attached piezoelectric element or by other means) that allows the OPO to be continuously tuned over substantial ranges, enabling rapid, wide continuous tuning of the OPO output frequency or frequencies.

The present invention provides a stent for implantation at a site within a human or animal body comprising: an expandable body having an inner surface and an outer surface; and treatment agents applied to the outer surface of the expandable body, the treatment agents comprising a combination of Paclitaxel and FK506 or their derivatives or analogues.

The present invention relates to methods and compositions which may be used to immunize infant mammals against a target antigen, wherein an immunogeniclly effective amount of a nuclic acid encoding a relevant epitope of a desired target antigen is administered to the infant. It is based, at least in part, on the discovery that such genetic immunization of infant mammals could give rise to effective cellular and humoral immune responses against target antigens.

The invention provides methods and compositions comprising a novel stabilized monovalent antibody fragment.

Bone metabolic disorders are treated by administering to an individual a therapeutically effective amount of a peripheral opioid antagonist at one or more of the opioid receptors, including the various naloxone and naltrexone analogs or a pharmaceutically acceptable salt thereof. The invention is further embodied in the use of peripheral antagonists of the opioid receptors, such as the use of naltrexone and naloxone analogs, which can be opioid antagonist with peripheral selectivity at the μ opioid receptor, for the treatment of bone loss, osteoporosis, osteopenia and other bone disorders in individuals using opioid drugs, including patients using opioids for analgesia and in opioid drug-dependent individuals

Motor vehicle wheel including a wheel rim and a tire having a tire interior enclosed by the wheel rim and the tire. The tire is mounted on the wheel rim, and the wheel also includes an insert composed of a ring-shaped sound-absorbing material that is positioned within the tire interior. The wheel further includes an acoustically transparent support element having tensile strength, at least in a circumferential direction of the tire, that is coupled to the insert.

A second device (24) is mounted on a first device (22) formed of a liquid crystal (27) display cell (26) at the front of which is arranged a first linear polarizer (40), of a liquid crystal (29) optical valve (28) at the back of which is arranged a second polarizer (44) and means (23) for controlling the valve (28) and the cell (26) from a switched state to a non switched state. When the cell (26) is switched to display a data item, by associating a first light or dark device (22) with a second absorbent or reflective polarizer (44), an inversion of the contrast in said data is obtained by switching the valve (28).

A moisture-reactive hot-melt adhesive composition is provided. Particularly, a composition that includes a polyisocyanate and at least two polyols, one of which is a fatty polyol. Also provided is a method for bonding substrates using the adhesive.

A plasma reactor includes an electrostatic chuck in the chamber for supporting the workpiece, a ceiling electrode facing the electrostatic chuck and an ESC electrode in the electrostatic chuck with an electrostatic clamping voltage supply coupled to the ESC electrode. The reactor further includes at least a first RF bias source of an LF or HF frequency coupled to the pedestal electrode, and first and second VHF power sources of different frequencies coupled to the same or to different ones of the electrodes. The first and second VHF power sources are of sufficiently high and sufficiently low frequencies, respectively, to produce center-high and center-low plasma distribution non-uniformities, respectively, in the chamber.

The invention relates to a matrix tablet for the prolonged release of gliclazide which ensures continuous and consistent release of the active ingredient after administration by the oral route, the release being insensitive to variations in the pH of the dissolution medium.

A current perpendicular to plane (CPP) GMR sensor having first and second outer pinned layers and a trilayer free layer therebetween. The free layer includes first and second outer magnetic layers, and a partially oxidized magnetic layer disposed there between. The middle partially oxidized layer is antiparallel coupled with the outer magnetic layers of the free layer by first and second coupling alyers which prevent oxygen migration from the central layer into the outer magnetic layers of the free layer. The partial oxidation of the middle layer provides a limited amount of electrical resistance at a desired location within the free layer to increase GMR.

A radio frequency bridge, useful for measuring complex values of an unknown impedance or associated complex reflection coefficient and VSWR value, which comprises an rf source, a novel asymmetrical bridge, a measuring device (comprising two logarithmic amplifiers, a difference amplifier and a phase detector), a computing device and a display or interface device. The complex impedance may be any two terminals of a general N-port network not to exclude an antenna with or without feed-line. The invention is more accurate than prior art when measuring complex impedance values having magnitudes from approximately five ohms to an upper value limited only by the dynamic range of the logarithmic amplifiers, normally greater than 4000 ohms. It has the great advantage of maintaining constant measuring accuracy over a wide measuring range and can be designed to operate over very wide bandwidths.

An enhanced DC plasma processing system which acts to immediately stop current from flowing through the plasma allows a variety of alternative embodiments for varying applications. In one embodiment, a tapped inductor is switched to ground to achieve substantial voltage reversal of about 10% upon detection of an arc condition through voltage and/or rate of voltage change techniques. This reversal of voltage is maintained long enough to allow restoration of uniform charge density within the plasma prior to restoration of the initial driving condition. A technique for preventing arc discharges involving periodically applying a reverse voltage is effected through a timer system in the power supply.

Drilling systems and methods for enlarging a borehole that include at least one expandable reamer and at least one expandable stabilizer axially spaced therefrom in a tubular string such as a drill string, the at least one expandable reamer and the at least one expandable stabilizer being independently actuatable by different-sized actuation devices. A relatively lower tool is actuatable by a smaller actuation device, such as a drop ball, which passes through a relatively higher tool in the drill string without triggering the higher tool.