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203results about How to "High efficiency load" patented technology

Magnetic resonance imaging nanometer drug carrier, and nanometer drug loading system and preparation method thereof

The invention discloses a magnetic resonance imaging nanometer drug carrier, and a nanometer drug loading system and a preparation method thereof. The magnetic resonance imaging nanometer drug carrieris a triblock polymer nanoparticle, wherein the triblock polymer is PLGA-PEI-PEG, and has active groups on the surface, and the active groups comprise amino, hydroxyl and carboxyl. According to the present invention, the drug carrier can efficiently load a nuclear magnetic resonance imaging drug and an antitumor drug to make the antitumor drug specifically reach the tumor lesion site, such that the nuclear magnetic resonance positioning of the superparamagnetic ferroferric oxide nanoparticle at the tumor region can be achieved while the high-selectivity and low-toxicity treatment effect can be achieved, and the disadvantages of poor selectivity, strong toxic-side effect, easy drug-resistance generation and the like of the traditional cytotoxic drugs can be overcome; and the preparation method is simple and is easy to perform, the prepared triblock polymer nanoparticle can be stably stored in the aqueous solution so as to be easily stored, and various functional groups exist on the surface of the particle, such that the prepared triblock polymer nanoparticle can be easily subjected to surface modification or surface functionalization.
Owner:JINAN UNIVERSITY

Preparation method of polyaniline/precious metal nanometer composite material modified electrode

The invention relates to a preparation method of a polyaniline/precious metal nanometer composite material modified electrode. The preparation method comprises the following steps of: pre-functionalizing the surface of the electrode to cause the surface of the electrode to have negative charge groups to obtain the functionalized electrode; causing the functionalized electrode to alternatively absorb in a polyaniline solution and a precious metal precursor solution respectively for 5-60 minutes to obtain a multi-membrane electrode; placing the multi-membrane electrode in an inert atmosphere at least for 8 hours, or electrochemically reducing the multi-membrane electrode in an aqueous solution of an electrolyte to obtain the polyaniline/precious metal nanometer composite material modified electrode. A product prepared by using the preparation method provided by the invention not only can be applied to detecting water pollution, but also can be used as catalysis devices based on precious metal nanometer, such as a biosensor, and a fuel cell; as the water soluble conductive polyaniline has the advantages of good conductivity, good electrochemical activity and the like, the preparation of a precious metal particle with the polyaniline as a carrier is mild in condition, environmentally-friendly, and simple in method; the polyaniline can be relatively stably fixed on the surface of the electrode when being used as an electrode catalysis material.
Owner:DONGHUA UNIV

Nano catalyst for tumor treatment, and preparation method and application thereof

ActiveCN110974978AImproving the Efficiency of Cancer TreatmentSmall toxicityHeavy metal active ingredientsDrug photocleavageNano catalystPtru catalyst
The invention provides a nano catalyst for tumor treatment, and a preparation method and application thereof. The nano catalyst provided by the invention comprises an erythrocyte membrane, and a composite nano enzyme and a photosensitizer which are coated in the erythrocyte membrane, wherein the composite nano enzyme comprises glucose oxidase and iron nanoparticles which are coated in an inner cavity of the glucose oxidase. The nano catalyst is preferentially accumulated at a target tumor site through targeted biomimetic delivery, and release of the composite nano enzyme is realized under irradiation of near infrared light. Based on high glucose uptake and a weakly acidic environment at the tumor site, glucose oxidase converts glucose into H2O2, induces iron nano particles to start an in-situ Fenton reaction, generates hydroxyl free radicals after sequential catalysis, induces tumor cells to be subjected to oxidative damage, and further kills the tumor cells. The nano catalyst not onlycan realize high-efficiency loading of the catalyst, but also can effectively prolong in-vivo circulation time, so that accurate and sustained release on a tumor focus part is realized, and a new thought and platform are provided for tumor treatment.
Owner:JINAN UNIVERSITY

Hierarchical collaborative decision-making intra-network resource scheduling method, system, and storage medium

The invention discloses a hierarchical collaborative decision-making intra-network resource scheduling method, a system, and a storage medium. The intra-network resource scheduling method comprises the steps of obtaining a computing power demand interest packet requested by an upstream network node in a computing power network; judging whether the current network node meets the computing power demand of the computing power demand interest packet or not, if yes, providing computing power service for data in the computing power demand interest packet according to a deployed performance function,and if not, providing forwarding service for the computing power demand interest packet. According to the technical scheme, the scheduling decision mechanism of the fine-grained local scheduling layer is optimized by means of global information, so that the utilization rate of resources such as global computing power and storage of the computing power network is improved, and load balancing of resources in the network is realized; besides, through the mode of combining the coarse-grained global scheduling layer and the fine-grained local scheduling layer, the non-end-to-end hierarchical collaborative decision-making intra-network resource scheduling capability is provided, the realization of an efficient and balanced intra-network resource scheduling function from the technical level is facilitated, and the overall performance of the computing power network is also improved.
Owner:PEKING UNIV SHENZHEN GRADUATE SCHOOL

Preparation method and application of near-infrared dye functionalized intelligent super-molecule vesicle

ActiveCN108524449AHigh efficiency loadExcellent near-infrared photothermal conversion performanceOrganic active ingredientsDrug photocleavageInfraredSolubility
The invention discloses a preparation method and an application of a near-infrared dye functionalized intelligent super-molecule vesicle. According to the preparation method, water solubility column [5] aromatic hydrocarbon (WP5) serves as a main body, a biquaternary ammonium salt functionalized near-infrared dye G based on perylene diimide serves as an objective body, the intelligent super-molecule vesicle is constructed by the aid of acting force of the main body and the objective body between the water solubility column [5] aromatic hydrocarbon and the near-infrared dye, and efficient loading of a drug (hydrophobic anticancer drug adriamycin) can be achieved in the self-assembly process. The near-infrared dye G has excellent near-infrared photo-thermal conversion performance and can serve as a photo-thermal treatment reagent of a tumor. The super-molecule drug load vesicle constructed by the aid of the acting force of the main body and the objective body between the WP5 and the near-infrared dye can stably exist in physiology environments and can rapidly and efficiently release a photo-thermal treatment reagent and a chemotherapy drug in tumor acidic micro-environments, collaborative treatment of photo-thermal treatment / chemotherapy is achieved, the super-molecule drug load vesicle is provided with a good drug delivery system, treatment effect of the tumor is greatly improved, and the super-molecule drug load vesicle has an excellent clinical application prospect.
Owner:NANJING UNIV OF POSTS & TELECOMM

3D porous zinc-loaded current collector, sodium or potassium-philic battery negative electrode and preparation and application thereof

The invention belongs to the field of an electrode material and particularly belongs to the field of sodium electricity and potassium electricity. The invention discloses a 3D porous zinc-loaded current collector. The 3D porous zinc-loaded current collector comprises a 3D porous current collector and metal zinc compounded on a framework of the 3D porous current collector, the invention further comprises a preparation method and an application of the 3D porous zinc-loaded current collector, in addition, the invention further provides a sodium negative electrode or a potassium negative electrodeprepared from the 3D porous zinc-loaded current collector. The 3D porous zinc-loaded current collector is advantaged in that the metal zinc is creatively compounded on a pore skeleton of the 3D porous current collector, and the current collector with the structure can effectively maintain the skeleton stability in the sodium or potassium metal deposition process, moreover, the metallic zinc uniformly distributed on the pore skeleton can induce nucleation of metallic sodium or potassium, so the effective specific surface area of the 3D current collector is fully utilized in the sodium or potassium deposition process, and dendritic-crystal-free sodium or potassium deposition and long cycle life are realized.
Owner:CENT SOUTH UNIV

Nano-drug simulating superoxide dismutase or catalase and preparation method and application thereof

The invention relates to a nano-drug simulating superoxide dismutase or catalase and a preparation method and application thereof. A nano-carrier is prepared from cyclodextrin derivatives with the hydrogen peroxide removing capacity, free radical scavenger drugs, lecithin and polyethylene glycol-distearoyl-phosphatidylethanolamine, wherein the mass ratio of the polyethylene glycol-distearoyl-phosphatidylethanolamine to the cyclodextrin derivatives is 2:100-1:1. The nano-drug prepared through the method is in a spherical shape, the particle size range is about 20-800 nm, and the free radical scavenger drugs are evenly distributed in the nano-drug. The preparation method comprises the steps that firstly, the lecithin and the polyethylene glycol-distearoyl-phosphatidylethanolamine are dissolved in water to obtain a water phase, and the cyclodextrin derivatives and the free radical scavenger drugs are dissolved in organic solvent to obtain an organic phase; secondly, the organic phase is slowly and dropwise added in the preheated water phase, centrifugal washing is performed, freeze drying is performed, and then the nano-drug is obtained. The nano-drug has the obvious preventing and treating effects on oxidative stress injury correlation diseases such as inflammatory bowel diseases, myocardial infarction and congestive heart failure.
Owner:ARMY MEDICAL UNIV

Antibacterial medical catheter coated with nano silver polymer cellular structure film

The invention relates to an antibacterial medical catheter coated with a nano silver polymer cellular structure film, which is formed by firmly coating a thin film containing a nano silver/polymer cellular structure on the surface of a common medical catheter used as the raw material and is used for realizing the dual antibacterial purposes of nano silver bacterium resistance as well as cellular structure bacterium resistance and adsorption. The invention is applicable to clinical medical catheters of various materials, sizes and shapes, and the medical catheters can be approximately distinguished into two classes, namely a catheter with an air bag on the far end and a catheter with no air bag on the far end. For the catheter with an air bag on the far end, a tracheal catheter is an example: the inner and outer surfaces of most of a catheter body (11), an air bag (15) and side holes (16) of the tracheal catheter are all coated with a nano silver/polymer cellular structure film (18). The nano silver/polymer cellular structure film mainly comprises a high molecular polymer (32) and nano silver particles (41), and is characterized in that the surface of the film is provided with regular cellular hole structures (33), and the nano silver particles specifically exist on interfaces of the holes and also exist in the substrate of the film.
Owner:SOUTHEAST UNIV
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