10results about How to "High efficiency load" patented technology

This invention relates to a biomass char composite electrocatalyst supported on nickel-cobalt sulfides, its preparation, and its application. The preparation method includes: subjecting biomass material to high-temperature carbonization to obtain a biomass char substrate with a porous structure; immersing the biomass char substrate in a solution containing nickel and cobalt salts, and obtaining biomass char supported on nickel-cobalt oxides through a hydrothermal reaction; placing the biomass char supported on nickel-cobalt oxides in a solution containing a sulfur source, and obtaining the biomass char composite electrocatalyst supported on nickel-cobalt sulfides through a hydrothermal reaction. The biomass char composite electrocatalyst supported on nickel-cobalt sulfides of this invention can be applied in biomass electrocatalytic oxidation reactions, achieving selective control of the biomass oxidation reaction and oxygen evolution reaction through an external magnetic field, thereby improving the efficiency of high-value conversion of biomass. The magnetic field control method of this invention has advantages such as non-contact control, simple system, and strong applicability, and has good application prospects.

This invention discloses a nanoRNA delivery system and its application in the control of Sclerotinia sclerotinia disease, relating to the field of biotechnology. The preparation method of the nanoRNA delivery system includes the following steps: mixing chitosan, sucrose, and aspartic acid uniformly and then subjecting them to a hydrothermal reaction to obtain a quantum dot-chitosan degradation product complex; mixing the quantum dot-chitosan degradation product complex with double-stranded RNA to obtain the nanoRNA delivery system; the double-stranded RNA is used to silence Sclerotinia sclerotinia virulence-related transcription factor genes. The nanoRNA delivery system provided by this invention can effectively protect RNA and exhibits a very high inhibitory effect on Sclerotinia sclerotinia in plants, providing a novel technical solution for the green and precise control of Sclerotinia sclerotinia disease.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The application discloses an LDH-based vaccine adjuvant and a preparation method and application thereof, and belongs to the technical field of aluminum adjuvant preparation of vaccines, and the preparation method comprises the following steps: mixing at least one of soluble magnesium salt, soluble zinc salt, soluble manganese salt and soluble calcium salt with soluble aluminum salt, and then performing a co-precipitation reaction with a sodium hydroxide aqueous solution in a colloid mill device, and performing crystallization to obtain LDH nanosheets; dispersing the LDH nanosheets in a PBS solution, adding a hepatitis B surface antigen molecule drug, uniformly mixing, and then performing centrifugation to obtain the LDH-based vaccine adjuvant. The LDH-based vaccine adjuvant can significantly promote the maturation of DC cells and the activation of T cells, and the total IgG level reflects the overall humoral immune response intensity of the body to vaccines or pathogens; the LDH-based vaccine adjuvant forms a "storage library" at an injection site to store antigens and slowly release the antigens, and the purpose of long-time continuous stimulation of the immune system in the body is achieved.

This invention discloses an iron-containing diatomaceous earth shell material, its preparation method, applications, and a method for preparing a tannic acid-diatomaceous earth shell composite material containing this material. The iron-containing diatomaceous earth shell material contains at least 0.4% iron by weight and at least 88% silicon, retaining the highly ordered nanoscale porous structure of natural diatomaceous earth shells. The preparation method involves culturing diatoms in G11 medium supplemented with sodium silicate nonahydrate and ferrous sulfate heptahydrate, followed by extraction via hydrogen peroxide oxidation, acid washing, and high-temperature calcination. This invention further utilizes the reaction of this iron-containing diatomaceous earth shell with tannic acid in a buffer system at pH 7.0-8.0, achieving efficient loading of tannic acid through the coordination of iron ions with tannic acid and physical adsorption. This invention features a simple process, low cost, and environmental friendliness. The prepared composite material significantly improves the chemical stability and bioavailability of tannic acid, showing broad application prospects in biomaterials fields such as drug delivery, antibacterial applications, and tissue engineering.

The invention belongs to the technical field of biological medicines, and particularly relates to vitexin-probucol self-assembled nanoparticles as well as a preparation method and application thereof. The nanoparticle is formed by self-assembly of vitexin and probucol, and the mass ratio of vitexin to probucol is 2: (1-5). The nano particles are prepared by adopting a nano precipitation method, and the method specifically comprises the following steps: mixing vitexin and probucol, and dissolving and dispersing in a good solvent to obtain a mixed solution; and adding the obtained mixed solution into a poor solvent, and promoting the vitexin and probucol to be self-assembled to form the nanoparticles by utilizing a solvent replacement effect. The nanoparticles have the advantages of high drug loading capacity, synergistic anti-inflammation and anti-oxidation, long-acting circulation and the like, and can effectively treat atherosclerosis, reduce side effects and improve the treatment effect and safety.

The application belongs to the technical field of molecular imaging and biomedical materials, and particularly relates to a construction method of a radioactively labeled magnetic T1-T2 synergistic MRI-PET bimodal imaging probe and application thereof. The polyphenol substance is dissolved in methanol, the pH is adjusted, SPIO is dispersed in tetrahydrofuran, after mixing, the water-phase SPIO modified by the polyphenol is obtained. Then, the streptavidin is dissolved in water, the polydopa coating layer is formed by in-situ polymerization of the polydopa and is coupled with the streptavidin, the biotin-modified targeting ligand is combined, the targeted MRI probe is obtained, and finally the radioactive metal element such as Cu, 64 Cu, 68 Ga is efficiently chelated to obtain the T1-T2 synergistic MRI-PET bimodal probe, the probe has the advantages of strong stability, high hydrophilicity, good biocompatibility, high relaxivity, good tumor targeting, high sensitivity of PET for whole body quantification, high soft tissue contrast of MRI T1-T2 and high spatial resolution.

This invention relates to the field of cosmetic raw material processing technology, and discloses a preparation process for active nano-encapsulated materials for cosmetics. The preparation process is as follows: Cosmetic active ingredients are added to an alkenylated modified chitosan solution and ultrasonically treated for 1-3 minutes. Then, thiolated silk fibroin is added and mixed evenly. Next, a photoinitiator, 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylphenylacetone, is added to the system. The mixture is irradiated under 365 nm ultraviolet light at room temperature for 10-20 minutes to obtain a dispersion of nano-hydrogel encapsulated materials containing the active ingredients. After ultrafiltration purification, 5% (w / w) of trehalose is added, stirred to dissolve, and freeze-dried to obtain active nano-encapsulated materials for cosmetics. The active nano-encapsulated materials for cosmetics prepared by this invention exhibit good stability, sustained-release and controlled-release properties, and antioxidant properties.

The present application relates to carbon capture combustion and composite metal material technical field, disclose a kind of composite oxygen carrier and its preparation method and application.The method includes the following steps: (1) active metal soluble salt solution is activated, and the active metal soluble salt solution obtained after activation, biomass particle template and adhesive are mixed, to obtain mixed solution;(2) the mixed solution is stirred, dried, calcined and screened in turn, to obtain composite oxygen carrier.The composite oxygen carrier has excellent multi-component petrochemical high-calorific value mixed gas reactivity, cycle stability, carbon deposition resistance, and the synthesis method and raw material source are rich and the preparation cost is low.