Nano catalyst for tumor treatment, and preparation method and application thereof

Abstract

The invention provides a nano catalyst for tumor treatment, and a preparation method and application thereof. The nano catalyst provided by the invention comprises an erythrocyte membrane, and a composite nano enzyme and a photosensitizer which are coated in the erythrocyte membrane, wherein the composite nano enzyme comprises glucose oxidase and iron nanoparticles which are coated in an inner cavity of the glucose oxidase. The nano catalyst is preferentially accumulated at a target tumor site through targeted biomimetic delivery, and release of the composite nano enzyme is realized under irradiation of near infrared light. Based on high glucose uptake and a weakly acidic environment at the tumor site, glucose oxidase converts glucose into H2O2, induces iron nano particles to start an in-situ Fenton reaction, generates hydroxyl free radicals after sequential catalysis, induces tumor cells to be subjected to oxidative damage, and further kills the tumor cells. The nano catalyst not onlycan realize high-efficiency loading of the catalyst, but also can effectively prolong in-vivo circulation time, so that accurate and sustained release on a tumor focus part is realized, and a new thought and platform are provided for tumor treatment.

Description

technical field

[0001] The invention relates to the technical field of nano-medicine, in particular to a nano-catalyst for tumor treatment and its preparation method and application. Background technique

[0002] At present, cancer has become the second leading cause of death in the world. It is well known that in the common treatments of cancer, such as chemotherapy, photodynamic therapy and photothermal therapy, there are various problems that limit their therapeutic efficiency or easily induce undesired tumor metastasis. Therefore, many researchers have explored different therapeutic strategies to improve the efficiency of tumor treatment methods and achieve more focused and effective tumor-specific treatments.

[0003] The microenvironment of the tumor lesion area has its particularity, such as weak acidity, high glutathione (GSH) level, hypoxia, etc., which play an extremely important role in the occurrence, development and metastasis of tumors. Nano-agents that can r...

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