A kind of protein and photosensitizer co-delivery pH-responsive polyamino acid nanogel and preparation method thereof

A polyamino acid and nanogel technology, applied in the field of biomedicine, can solve the problems of low photosensitizer transfer efficiency, poor protein escape ability, low protein loading efficiency, etc., to promote cell uptake, improve cancer treatment efficiency, good biophase Effects of Capacitance and Biodegradability
CN109498548BActive Publication Date: 2021-09-24JILIN INST OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JILIN INST OF CHEM TECH
Publication Date
2021-09-24

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Abstract

A protein and a photosensitizer co-deliver pH-responsive polyamino acid nanogel and its preparation method, belonging to the technical field of biomedicine. The pH-responsive nanogel prepared by the present invention is to initiate γ-benzyl-L-glutamic acid ester-N-endocarboxylate in one step by using polyethylene glycol monomethyl ether with an amine group as a macroinitiator. anhydride or γ‑benzyl‑L‑aspartic acid ester‑N‑internal carboxylic acid anhydride ring-opening polymerization to prepare the polyamino acid backbone, and then the tail of the backbone is used to graft photosensitizers, while the side chains are grafted with cationic molecules Modifications to increase protein loading capacity and lysosomal escape capacity. Finally, a pH-responsive nanogel system is constructed through the inner core cross-linking reaction, so as to achieve the purpose of safe delivery, targeted delivery, rapid cell uptake in vivo, release of proteins and activation of photosensitizers in vivo. This will help promote the development of combined protein and photodynamic therapy in the medical field.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a pH-responsive polyamino acid nanogel co-delivered by a protein and a photosensitizer and a preparation method thereof. Background technique

[0002] Cancer has become one of the serious diseases that threaten human health and has the highest mortality rate, and shows an increasing trend year by year. According to the latest data released by the National Cancer Center in 2017, about 10,000 people are diagnosed with cancer every day in the country, and the mortality rate is as high as 60%, and cancer patients are gradually becoming younger. Therefore, it is particularly important for human development, family happiness and even social harmony to develop a cancer treatment system that is non-toxic, efficient, safe and coexistent with multiple treatments.

[0003] At present, the commonly used methods for the treatment of malignant tumors are chemotherapy and radio...

Claims

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