The invention belongs to the technical field of biological
medicine, and particularly relates to a self-heating microneedle patch for delivering vaccines and application of the self-heating microneedle patch. The patch consists of an upper-layer self-heating patch and a lower-layer
medicine-carrying microneedle patch, the self-heating patch contains a heating material in a specific ratio, the
drug-loaded microneedle patch takes 10kDa
hyaluronic acid as a base material, a needle tip is coated with an
antigen and / or an
immunologic adjuvant, a microneedle is prepared by a molding method, and the self-heating patch can increase the temperature of local
skin to 39-45 DEG C. The invention further discloses a preparation method of the patch. The preparation method comprises the steps of preparing the
drug-loaded microneedle and the self-heating patch and compounding the
drug-loaded microneedle and the self-heating patch. The patch can be used for preparing anti-tumor
immunotherapy drugs, can promote recruitment and maturation of dendritic cells and
cross presentation of antigens through local heating, can enhance immune response of CD8 + T cells, has the advantages of
safe delivery, immunological enhancement, high
patient compliance and wide application range, and is remarkable in in-vivo anti-tumor effect and good in clinical transformation prospect.