The invention relates to a method for preparing a constructed body from a biobrick containing endothelial cells, belonging to the technical fields of biology, regenerative medicine, biological printing (e.g., 3D biological printing), tissue engineering, etc. Particularly, the invention relates to a biobrick applicable to biological printing (e.g., 3D biological printing) and tissue engineering, a composition (e.g., biological ink) including the biobrick, a preparation method and application of the biobrick and the constructed body (e.g., a three-dimensional constructed body) including the biobrick or constructed by using the biobrick/biological ink. The biobrick comprises cells, a core wrapping cells (e.g., endothelial cells), and a shell encapsulating the core.