The invention relates to a comb-shaped exchange vertical-lifting type mechanical stereoscopic parking garage. The garage comprises a lifting system, a transverse conveying system, a lifting comb platform, a transverse comb platform, a passing storehouse room, a protecting platform and an automatic control system. The garage is characterized in that operations of lifting, transversely conveying, turning around by rotating of automobiles can be smoothly linked through comb exchange of the lifting comb platform, the transverse comb platform and a rotary plate steel frame; meanwhile, each link is individually driven, each sub-system only carries out one-dimensional movement in space, that is to say, the lifting system is only responsible for conveying the automobile to vertically move up and down, the transverse conveying system is only responsible for conveying the automobile to parallel move left and right, and a rotating platform in the passing storehouse room is only responsible for turning the automobile around; and in addition, the protecting platform arranged above the passing storehouse room can shield objects falling from high altitudes, and prevent fallen objects from hurting people to ensure that the passing storehouse room is at a safety protection state. The comb-shaped exchange vertical-lifting type mechanical stereoscopic parking garage disclosed by the invention has the advantages of scientific design, ingenious structure, small floor area, high automobile parking and take-out speeds, good safety and the like.