A tumor microenvironment-responsive self-assembly integrated diagnosis and treatment reagent and its preparation method

A tumor microenvironment and responsive technology, which can be applied in preparations for in vivo experiments, antineoplastic drugs, photodynamic therapy, etc., can solve the problems of low delivery efficiency of photosensitizers, poor tumor retention ability, poor diagnostic sensitivity, etc., to achieve Good stability and biocompatibility, improved diagnostic accuracy, reproducible effect
CN109513015BActive Publication Date: 2021-06-04JILIN JUNTONGXING BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JILIN JUNTONGXING BIOTECH
Publication Date
2021-06-04

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Abstract

A tumor microenvironment-responsive self-assembly diagnosis and treatment integration reagent and a preparation method thereof belong to the field of self-assembly nano-biomedical technology. The integrated diagnosis and treatment reagent obtained in the present invention is composed of free carboxyl groups generated in multifunctional polymer ligands and trivalent metal gadolinium ions. It has the ability to induce surface charge conversion in the acidic environment outside tumor cells and promote cell uptake. It also has the function of glutathione in tumor cells to activate fluorescent signals and photodynamic therapy, and at the same time successfully combines direct visualization, high sensitivity, and radiation-free nuclear magnetic imaging diagnosis with high selectivity and high curative effect. Infrared photodynamic therapy is fused together, and only a simple coordination self-assembly can achieve two functions of diagnosis and treatment at the same time, effectively combining diagnosis and treatment, reducing the complexity of preparation, and improving diagnosis and treatment. efficiency.
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Description

technical field

[0001] The invention belongs to the technical field of self-assembly nano-biomedicine, and specifically relates to a tumor microenvironment-responsive self-assembly diagnosis and treatment integration reagent and a preparation method thereof. Background technique

[0002] Cancer is one of the chief culprits of killing human life. Many people talk about cancer, and the fight against cancer has never stopped. According to the latest data released by the American Cancer Center in 2017, there are currently 12 million newly diagnosed cancer cases and more than 7 million deaths each year, and the morbidity and mortality are still rising year by year. What is more serious is that cancer patients are gradually tend to be younger. Therefore, the development of non-toxic, efficient and personalized diagnosis and treatment integration reagents is an effective way to improve the efficiency of tumor diagnosis and treatment, and will also play a positive role in human dev...

Claims

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