A ROS-sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and preparation method thereof

A photodynamic therapy and sensitivity technology, applied in the field of biomedicine to achieve good biocompatibility and biodegradability, enhance the effect of ferroptosis, and improve the efficiency of cancer treatment
CN112451680BActive Publication Date: 2022-07-19JILIN INST OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
JILIN INST OF CHEM TECH
Publication Date
2022-07-19

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Abstract

A ROS-sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and a preparation method thereof belong to the technical field of biomedicine. The nano-reagent is constructed from a photosensitizer-modified ROS-sensitive amphiphilic block polymer, including an amphiphilic biodegradable polymer, a photosensitizer group attached to the tail end, and a side-chain-modified ferroptosis-inducing ROS. Sensitive sensitive monomer; amphiphilic polymer can self-assemble into a ROS-sensitive nanoagent with synergistic induction of photodynamic therapy and ferroptosis, in which the hydrophobic part self-assembles into a hydrophobic core and the hydrophilic part becomes hydrophilic shell. Finally, the self-assembly of the photosensitizer-modified ROS-sensitive amphiphilic block polymer is driven by the thin-film dispersion method into a ROS-sensitive nano-agent that can synergistically induce photodynamic therapy and ferroptosis. Synergistic effect of photodynamic and ferroptosis therapy on tumor growth inhibition.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and in particular relates to a ROS (Reactive Oxygen Species, reactive oxygen species) sensitive nano-agent with synergistic induction of photodynamic therapy and ferroptosis and a preparation method thereof. Background technique

[0002] Cancer is the old enemy of human health in our country and even in the world, and the incidence of cancer is also increasing day by day. The latest survey results show that in 2019, there were more than 20 million new cases of cancer worldwide, and more than 10 million deaths. Among them, the number of cancer incidence and deaths in China ranks first in the world. At present, the commonly used cancer treatment methods cannot provide satisfactory therapeutic effects, and have the defects of low specificity, strong toxic and side effects, and high recurrence rate. Early cancer is difficult to find, and tumor cells are easy to metastasize and spread through ly...

Claims

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