ROS-sensitive nano-reagent capable of synergistically inducing photodynamic therapy and ferroptosis and preparation method therefor

A photodynamic therapy and sensitive technology, applied in the field of biomedicine, achieves flexible repeatability, enhanced ferroptosis effect, and simple method

Active Publication Date: 2021-03-09
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, with the continuous development of medical technology, the drug resistance of some tumor cells has also emerged. A single treatment system can no longer meet the requirements of current cancer treatment. We need to combine multiple treatment methods to develop new nano-drug preparations

Method used

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  • ROS-sensitive nano-reagent capable of synergistically inducing photodynamic therapy and ferroptosis and preparation method therefor
  • ROS-sensitive nano-reagent capable of synergistically inducing photodynamic therapy and ferroptosis and preparation method therefor
  • ROS-sensitive nano-reagent capable of synergistically inducing photodynamic therapy and ferroptosis and preparation method therefor

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Embodiment Construction

[0056] The invention will be described in detail below in conjunction with the accompanying drawings and specific examples. The examples are used to help understand the present invention and should not be regarded as limiting the protection scope of the present invention.

[0057] Under careful inspection, the steps of the examples must be consistent with the steps described in the summary of the invention; the raw materials in the examples must be one of the raw materials described in the summary of the invention; the process parameters such as the amount of raw materials, time and temperature in the examples must be Within the data range described in the summary of the invention!

[0058] (1) Preparation of mPEG-b-P(ED-AA)LG-Ce6

[0059] (1) The synthesis process of mPEG-b-P(ED-AA)LG-Ce6 is shown in formula (I). First, 1 g of methoxypolyethylene glycol amine (mPEG-NH 2 , the average molecular weight is 5000) and 1.0532g of BLG-NCA were mixed and dissolved in 30mL of anhydr...

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Abstract

The invention relates to a ROS-sensitive nano-reagent capable of synergistically inducing photodynamic therapy and ferroptosis and a preparation method therefor and belongs to the technical field of biomedicines. The nano-reagent is constructed from a photosensitizer-modified ROS-sensitive amphiphilic block polymer and comprises an amphiphilic biodegradable polymer and a ROS-sensitive perceptual monomer capable of inducing the ferroptosis, of which a tail end is connected with a photosensitizer group and a lateral chain is modified; and the amphiphilic polymer can self-assemble to form the ROS-sensitive nano-reagent capable of synergistically inducing the photodynamic therapy and the ferroptosis, a hydrophobic part self-assembles to form a hydrophobic core, and a hydrophilic part becomes ahydrophilic shell. Finally, the photosensitizer-modified ROS-sensitive amphiphilic block polymer is driven to self-assemble to form the ROS-sensitive nano-reagent capable of synergistically inducingthe photodynamic therapy and the ferroptosis by using a film dispersion method, and the effect of inhibiting tumor growth by a synergistic action of photodynamic and ferroptosis treatment in the presence of a tumorous microenvironment is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a ROS (Reactive Oxygen Species, reactive oxygen species) sensitive nano-reagent capable of synergistically inducing photodynamic therapy and ferroptosis and a preparation method thereof. Background technique [0002] Cancer is the old enemy of human health in our country and even in the world, and the incidence of cancer is also increasing day by day. The latest survey results show that in 2019, there will be more than 20 million new cases of cancer worldwide, and more than 10 million deaths. Among them, the incidence and death toll of cancer in China ranks first in the world. At present, commonly used cancer treatment methods cannot provide satisfactory therapeutic effects, and have defects such as low specificity, strong side effects, and high recurrence rate. Early cancer is difficult to find, and tumor cells are easy to spread through lymphatic vessels and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/59A61K31/202A61K41/00A61P35/00B82Y5/00C08G69/10C08G69/48
CPCA61K47/59A61K41/0071A61K41/0076A61K31/202A61P35/00B82Y5/00C08G69/10C08G69/48A61K2300/00
Inventor 杨洪雨杜嘉萌付雁王楠楠刘长玲
Owner JILIN INST OF CHEM TECH
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