Graphene oxide nanometer material modified by polyacrylic acid, and preparation method and application of graphene oxide nanometer material

A technology of polyacrylic acid and nanomaterials, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, inorganic non-effective ingredients, etc.

Active Publication Date: 2017-01-25
TIANJIN AGRICULTURE COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of nanomaterials by modifying polyacrylic acid polymers on graphene oxide by in situ atom transfer radical polymerization has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Preparation of graphene oxide: Add 48mL of concentrated sulfuric acid into a 250mL three-neck round bottom flask, place it in an ice-water bath, control the temperature below 10°C, add 1.5g of natural graphite powder under magnetic stirring conditions, 0.75g After stirring fully, slowly add 7g of potassium permanganate. After the potassium permanganate was added, the reaction was performed under magnetic stirring for 150 minutes. The temperature was raised to 35°C, and the reaction was carried out for 120 minutes. Then slowly add 40ml of ultrapure water, raise the temperature to 85°C, stir for 60min, slowly add a certain amount of hydrogen peroxide (10%), and react for 60min. The obtained product is washed several times, centrifuged, and the graphite oxide obtained by the centrifugation is freeze-dried in a freeze dryer. After the freeze-drying is completed, the obtained product is added to distilled water and ultrasonicated for 90 minutes to obtain graphene oxide.

Embodiment 2

[0014] Preparation of surface-modified graphene oxide with amino groups: Add 1.5g graphene oxide to 220mL DMF, sonicate for 1 hour, add 3g EDC and 3g NHS (dissolved in 20ml DMF), stir for 3 hours, slowly add 5ml ethylenediamine dropwise , reacted for 24 hours, centrifuged, and washed with ultrapure water to obtain amino-modified graphene oxide.

Embodiment 3

[0016] Preparation of surface-modified bromine-based graphene oxide: Add 1.0 g of amino-modified graphene oxide to a mixed solvent of tetrahydrofuran and triethylamine, sonicate for 1 hour, and add 1.2 ml of bromoisobutyryl bromide under ice water conditions , react in an ice-water bath for 3 hours, heat up to 35° C., react for 48 hours, wash with tetrahydrofuran, centrifuge, and freeze-dry to obtain bromo-modified graphene oxide.

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PUM

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Abstract

The invention discloses a graphene oxide nanometer material modified by polyacrylic acid, and a preparation method and application of the graphene oxide nanometer material. The nanometer material has the pH value response performance, and can be applied as a nanometer medicine carrier for protecting a medicine from action of acid environment and enzyme in the acid environment in the stomach. Meanwhile, the material can be applied as an adsorbing agent for adsorbing organic dye, pigment and heavy metal materials in water in an aspect of sewage treatment; the separation from the sewage can be realized through the pH value change.

Description

technical field [0001] The invention relates to a polyacrylic acid-modified graphene oxide nanometer material and a preparation method and application thereof. The nanomaterial has pH value responsiveness, can be applied as a nanometer drug carrier, and can protect the drug from the acidic environment and the action of enzymes in the acidic environment of the stomach. At the same time, the material can be used as an adsorbent to adsorb organic dyes, pigments and heavy metal materials in water in sewage treatment, and can be separated from sewage by changing the pH value. Background technique [0002] Graphene oxide is generally obtained by treating graphite powder with a strong acid to obtain graphite intercalation compounds, and then oxidizing the compounds with a strong oxidant, and finally ultrasonically obtained. Due to its large specific surface area, excellent modifiability, and easy combination with aromatic ring compounds, it has potential application prospects in m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F292/00C08F220/18A61K47/04A61K47/32
CPCA61K47/02A61K47/32C08F292/00C08F220/1804
Inventor 许艳玲王倩尚志强于丰洋李晴吴庭芳
Owner TIANJIN AGRICULTURE COLLEGE
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