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Antibacterial medical catheter coated with nano silver polymer cellular structure film

A honeycomb structure, medical catheter technology, applied in catheters, balloon catheters, stents, etc., can solve the problems of low surface coverage efficiency, low release efficiency, and poor firmness of antibacterial components, and achieve firm load, reduce adsorption, and firm surface. attached effect

Inactive Publication Date: 2012-03-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are two problems in the current existing technology: the surface coating of nano-silver on the endotracheal tube has poor firmness and low release efficiency
In general coating technology, there are two problems: coating efficiency and erosion resistance
At the same time, this kind of coating also has the problem of antibacterial efficiency of nano-silver releasing silver ions
[0007] In the research of antibacterial catheters, the main solution is through surface modification. The disadvantage is that the surface coverage efficiency of antibacterial components is low and it is easy to be eluted

Method used

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  • Antibacterial medical catheter coated with nano silver polymer cellular structure film
  • Antibacterial medical catheter coated with nano silver polymer cellular structure film
  • Antibacterial medical catheter coated with nano silver polymer cellular structure film

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Dissolve 1 g of medical polyurethane masterbatch in 50 ml of tetrahydrofuran. Add 0.1 g of silver nitrate, and add 1 ml (0.001 g / ml) of sodium borohydride ethanol solution under the condition of vigorous stirring to prepare a nano-silver / polymer composite solution for use.

[0040] Ordinary endotracheal tubes are washed and dried, immersed in the composite solution for 30 seconds, taken out, and naturally volatilized to form a film at a humidity of 90% for about 5-10 minutes to prepare a nano-silver / polymer honeycomb structure-coated antibacterial endotracheal tube. The average thickness of the coating is 50 μm, the average pore diameter of the honeycomb structure is about 5 μm, and the silver content is 10%.

Embodiment 2

[0042] Dissolve 5g of medical polyurethane masterbatch in 50ml of tetrahydrofuran. Add 0.1 g of silver nitrate, and add 5 ml (0.001 g / ml) of sodium borohydride ethanol solution under the condition of vigorous stirring to prepare a nano-silver / polymer composite solution for use.

[0043] After washing and drying the ordinary endotracheal tube, immerse in the composite solution for 30 seconds, take it out, and naturally volatilize to form a film at a humidity of 90%, about 5-10 minutes, and make a nano-silver / polymer honeycomb structure coated antibacterial endotracheal tube , the average thickness of the coating is 200 μm, the pore size of the honeycomb structure is about 3 μm, and the silver content is 2%.

Embodiment 3

[0045] Dissolve 1 g of medical polyvinyl chloride masterbatch in 50 ml of tetrahydrofuran. Add 0.01 g of silver nitrate, and add 1 ml (0.001 g / ml) of sodium borohydride ethanol solution under the condition of vigorous stirring to prepare a nano-silver / polymer composite solution for use.

[0046] After washing and drying the ordinary endotracheal tube, immerse in the composite solution for 30 seconds, take it out, and naturally volatilize to form a film at a humidity of 90%, about 5-10 minutes, and make a nano-silver / polymer honeycomb structure coated antibacterial endotracheal tube , the average thickness of the coating is 50 μm, the pore size of the honeycomb structure is about 5 μm, and the silver content is 1%.

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Abstract

The invention relates to an antibacterial medical catheter coated with a nano silver polymer cellular structure film, which is formed by firmly coating a thin film containing a nano silver / polymer cellular structure on the surface of a common medical catheter used as the raw material and is used for realizing the dual antibacterial purposes of nano silver bacterium resistance as well as cellular structure bacterium resistance and adsorption. The invention is applicable to clinical medical catheters of various materials, sizes and shapes, and the medical catheters can be approximately distinguished into two classes, namely a catheter with an air bag on the far end and a catheter with no air bag on the far end. For the catheter with an air bag on the far end, a tracheal catheter is an example: the inner and outer surfaces of most of a catheter body (11), an air bag (15) and side holes (16) of the tracheal catheter are all coated with a nano silver / polymer cellular structure film (18). The nano silver / polymer cellular structure film mainly comprises a high molecular polymer (32) and nano silver particles (41), and is characterized in that the surface of the film is provided with regular cellular hole structures (33), and the nano silver particles specifically exist on interfaces of the holes and also exist in the substrate of the film.

Description

technical field [0001] The invention relates to a nano-silver / polymer honeycomb structure-coated antibacterial medical catheter, which realizes double antibacterial purposes through nano-silver antibacterial and honeycomb structure antibacterial adsorption. It belongs to the technical field of medical equipment. Background technique [0002] In recent years, nosocomial infection has become an important cause of death in hospitalized patients. According to the NHSN report, the top four factors leading to nosocomial infection are vascular catheter-related infection, ventilator-associated pneumonia (VAP), and ventilator-associated pneumonia (VAP). Both dialysis catheter infection and urinary catheter infection are related to the implantation of biological catheters. The common mechanism of medical catheter-related infections is the formation of biofilm on the catheter surface. [0003] Bacterial biofilms are bacterial biofilms that adsorb on the surface of medical biomaterials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61M25/10A61L29/12A61L29/16A61L29/14A61F2/958
Inventor 王醒顾宁江筱莉张天柱
Owner SOUTHEAST UNIV
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