Drug carrier capable of realizing sustained release of drug

A drug and carrier technology, applied in the field of drug carriers for sustained release of drugs, can solve problems such as drug safety issues

Inactive Publication Date: 2011-04-06
钟术光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It should be pointed out that the drug carrier disclosed by this technology may also have drug safety problems such as sudden drug release or dose-dumping.

Method used

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  • Drug carrier capable of realizing sustained release of drug
  • Drug carrier capable of realizing sustained release of drug
  • Drug carrier capable of realizing sustained release of drug

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Embodiment Construction

[0028] The matrix of the drug carrier and the material for controlling the release of the drug involved in the present invention are pharmaceutically acceptable aliphatic additives with a melting point higher than 37°C and a melting point higher than 37°C when in contact with body fluids in the body cavity, preferably Aliphatic additives with a melting point of 40°C to 90°C, more preferably 40°C to 70°C, more preferably 40°C to 50°C, the aliphatic additives include but are not limited to melting point Animal and vegetable oils, semi-synthetic oils, fatty acid glycerides, waxes, higher fatty acids, higher fatty alcohols, higher fatty acid esters, higher Aliphatic hydrocarbons and their mixtures.

[0029] Among them, fatty acid glycerides whose melting point is higher than the temperature of 37°C and whose melting point is also higher than the temperature of 37°C when in contact with body fluids in the body cavity are most preferred. The fatty acid glycerides used in the presen...

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Abstract

The invention discloses a drug carrier capable of realizing sustained release of a drug, which improves the performances and contains (a) an aliphatic additive, wherein the in vivo melting point and the in vitro melting point are higher than the temperature of 37 DEG C; (b) water-soluble additive particles with low viscosity and no irritation; (c) a water-insoluble acidic (or alkaline) polymer with water swelling property; (d) an alkaline (or acidic) surfactant; and (e) the drug. The drug carrier has better drug release property, higher resistance to salt poisoning, lower mucosa irritation, better biocompatibility and better drug release uniformity, can better ease or solve the problem of end release, and is difficult to cause initial burst release of the drug or dose dumping and other drug safety problems.

Description

technical field [0001] The invention relates to a medicine carrier for sustained release of medicine. More specifically, the present invention relates to a drug carrier for sustained-release drugs with improved properties, the drug carrier includes aliphatic additives with an in vivo and in vitro melting point greater than temperature 37, water-soluble low-viscosity additive particles, water-swellable Water-insoluble acidic polymers, alkaline surfactants and drugs. technical background [0002] Sustained-release preparations such as sustained-release suppositories, especially those with oily materials as the main sustained-release material, often exhibit the so-called "terminal release" problem, that is, the release of the drug is fast in the early stage, gradually slows down in the middle stage, and slows down in the later stage. Often, a part of the drug remains in the matrix within the specified (or expected) action time, and cannot play the expected role, or it is manif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61K47/44A61K9/00A61K9/02A61K47/18A61K47/26
Inventor 钟术光
Owner 钟术光
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