Preparation method of porous nano-hydroxyapatite sustained release gel

A technology of nano-hydroxyapatite and hydroxyapatite, which is applied in the field of materials, can solve the problems of toxicity and reduce the biological activity of porous hydroxyapatite, and achieve the effects of accelerating metabolism time, enhancing suspension stability, and uniform size distribution

Inactive Publication Date: 2019-03-29
SHANGHAI MOYANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The organic template method needs to select a suitable surfactant. In some cases, the selected surfactant may be toxic and needs to be removed at high temperature, which reduces the biological activity of porous hydroxyapatite.

Method used

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  • Preparation method of porous nano-hydroxyapatite sustained release gel
  • Preparation method of porous nano-hydroxyapatite sustained release gel
  • Preparation method of porous nano-hydroxyapatite sustained release gel

Examples

Experimental program
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Effect test

Embodiment 1

[0028] A method for preparing a porous nano-hydroxyapatite sustained-release gel of the present embodiment, the method comprises the following steps:

[0029] Step 1: adding nano-hydroxyapatite powder into water to prepare a hydroxyapatite slurry with a content of 10-40% (w / v);

[0030] Step 2: mixing the hydroxyapatite slurry, pore-forming agent and oleic acid in proportion, wherein the weight ratio of the hydroxyapatite slurry to the pore-forming agent is 80:20. Put it in a ball mill for 6-24 hours to get a uniform suspension; the pore-forming agent is carbon powder.

[0031] Step 3: Add the suspension to an organic compounding agent to mix in proportion, and then put it into an 80° C. water bath and stir to dissolve; the organic compounding agent is a combination of gelatin, gum arabic, chitosan, and sodium alginate. The stirring rate of the water bath is 600r / min, and the dissolution time is 5h.

[0032] Step 4: Dissolve the homogeneous suspension for spray drying and gr...

Embodiment 2

[0038] A method for preparing a porous nano-hydroxyapatite sustained-release gel of the present embodiment, the method comprises the following steps:

[0039] Step 1: adding nano-hydroxyapatite powder into water to prepare a hydroxyapatite slurry with a content of 10-40% (w / v);

[0040] Step 2: mixing the hydroxyapatite slurry, pore-forming agent and oleic acid in proportion, wherein the weight ratio of the hydroxyapatite slurry to the pore-forming agent is 85:15. Put it in a ball mill for 6-24 hours to get a uniform suspension; the pore-forming agent is carbon powder.

[0041] Step 3: Add the suspension to an organic compounding agent to mix in proportion, and then put it into a 50° C. water bath and stir to dissolve; the organic compounding agent is a combination of gelatin, gum arabic, chitosan, and sodium alginate. The stirring rate of the water bath is 250r / min, and the dissolution time is 5h.

[0042] Step 4: Dissolve the homogeneous suspension for spray drying and gra...

Embodiment 3

[0048] A method for preparing a porous nano-hydroxyapatite sustained-release gel of the present embodiment, the method comprises the following steps:

[0049] Step 1: adding nano-hydroxyapatite powder into water to prepare a hydroxyapatite slurry with a content of 10-40% (w / v);

[0050] Step 2: mixing the hydroxyapatite slurry, pore-forming agent and oleic acid in proportion, wherein the weight ratio of the hydroxyapatite slurry to the pore-forming agent is 95:5. Put it in a ball mill for 6-24 hours to get a uniform suspension; the pore-forming agent is carbon powder.

[0051] Step 3: Add the suspension to an organic compounding agent to mix in proportion, and then put it into a 50° C. water bath and stir to dissolve; the organic compounding agent is a combination of gelatin, gum arabic, chitosan, and sodium alginate. The stirring rate of the water bath is 250r / min, and the dissolution time is 5h.

[0052] Step 4: Dissolve the homogeneous suspension for spray drying and gran...

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Abstract

The invention discloses a preparation method of porous nano-hydroxyapatite sustained release gel. Hydroxyapatite composite microspheres prepared by the preparation method disclosed by the invention are uniform in size distribution, and have a granularity distribution range of 10-100 microns as well as a central particle size of 20-60 microns. By adding organic phase in mixing process, suspension stability of a suspension can be effectively enhanced; so that, the prepared microspheres can be used as an internal support material used for injection for the microspheres are uniform in size distribution and larger in particle size compared with microspheres prepared by conventional spray-drying methods. Moreover, the microspheres are relatively good in shape and high in porosity; so that, the microspheres are capable of enhancing injectability of materials, promoting shortening of drug metabolism time, maintaining stable and effective drug concentration in vivo, as well as ensuring good drug release properties.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a method for preparing a porous nano-hydroxyapatite slow-release gel. Background technique [0002] Hydroxyapatite (HAP) has attracted extensive attention from biomaterials and medical experts because its structure and composition are very close to human bone tissue. HAP is used as a bone filling material in orthopedics, stomatology and plastic surgery. In addition, HAP is also used as a carrier for growth factors and drugs, and shows good slow-release performance. In order to meet different clinical needs, researchers have prepared HAPs in different shapes such as rods, dumbbells, spheres, and flakes. Spherical hydroxyapatite has attracted great attention due to its strong fluidity, large specific surface area, and high packing density. [0003] There are many methods for preparing hydroxyapatite microspheres, such as hydrothermal method, emulsification cross-lin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/52A61L27/56A61L27/54
CPCA61L27/12A61L27/52A61L27/54A61L27/56A61L2400/12A61L2300/602A61L2430/02A61L2430/12A61K9/1611A61L27/20A61L27/58A61L2400/06A61K9/06A61K47/36C08L5/04
Inventor 林光明
Owner SHANGHAI MOYANG BIOTECHNOLOGY CO LTD
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