Tablet with improved combination properties and preparation method thereof

Abstract

The invention discloses a tablet with improved combination properties. The tablet comprises an active constituent, a water soluble crystalline granular or powdered diluent, a melting adhesive, a melting mechanical property improver and / or does not comprise a pharmaceutically acceptable additive, wherein the diluent and / or the active constituent are / is adhered and bridged by the cured smelt of theadhesive and the mechanical property improver; the ratio of the mechanical property improver to the summation of the adhesive and the mechanical property improver is 0.25-0.70, and the ratio of the diluent to the summation of the adhesive, the mechanical property improver and the diluent is 0.40-0.93; the content of the diluent is not lower than 25 percent; and the contents of the adhesive and the mechanical property improver are not lower than 5 percent. The invention also discloses a preparation method of the tablet. The tablet has the advantages of stronger mechanical property, better weather resistance, better hydrophilcity, higher porosity and better disintegration property.

Description

technical field [0001] The invention relates to a tablet with improved comprehensive properties. More specifically, it is a hydrophilic tablet with higher porosity, better weather resistance, and further enhanced mechanical properties. The invention also relates to a preparation method of the tablet. Background of the invention [0002] The porosity and mechanical strength of the tablet play a very important role in the tablet. High porosity is beneficial to the dissolution release of drugs in tablets, especially poorly soluble drugs, especially tablets that disintegrate / dissolve rapidly in the oral cavity. High mechanical strength is conducive to maintaining the shape of the tablet during production and transportation, ensuring the accuracy of a single dose, thereby ensuring the safety of medication. [0003] However, the high porosity of the tablet often leads to problems such as insufficient mechanical strength of the tablet, such as low hardness and poor friability, w...

AI Technical Summary

Problems solved by technology

[0006] In practical application, the above-mentioned technologies all show the disadvantages of unsatisfactory mechanical strength to varying degrees, such as insufficient hardness and insufficient brittleness, and problems such as cracks and fragments are prone to occur in the process of production and transportation.

There is still room for improvement in its mechanical properties

In addition, since the melting point of the generally disclosed meltable adhesive with better hydrophilicity is relatively low, the adhesive may be damaged when the preparation using the melting point as the adhesive is stored in an indoor environment that is not fully equipped with air-conditioning equipment in summer. Melting, the tablet becomes soft, changes the strength of the tablet and the disintegration time in the oral cavity, etc., and deteriorates the weather resistance or the ability to withstand higher temperatures

However, the lipophilic meltable adhesive with relatively high melting point has poor hydrophilicity, and the disintegration or drug dissolution of the prepared preparation is relatively slow.

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