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Synthetic method of kreatine

A synthetic method and creatine technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of long reaction time and complicated operation process, and achieve the effect of short reaction time and simple operation process

Inactive Publication Date: 2012-07-18
JIANGSU YUANYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction time of the above-mentioned reaction mode is long, and the operation process is complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Put 300 kg of water in a 1000L stainless steel reactor with stirring, heating, and reflux devices, then add 117 kg of N-methylguanidinoethanol, and add 348 kg of MnO under stirring. 2 , and then heated to a temperature of 110°C in the kettle, and continued to react for 12 hours, ended the reaction, filtered while hot to obtain a creatine solution, cooled to 20°C, and dried to obtain 100.5 kg of finished product with a yield of 76.71%.

Embodiment 2

[0017] Put 300 kg of water in a 1000L stainless steel reactor with stirring, heating, and reflux devices, then add 117 kg of N-methylguanidinoethanol, and add 609 kg of MnO under stirring. 2 , and then heated to a temperature of 70°C in the kettle, and continued to react for 20 hours, ended the reaction, filtered while hot to obtain a creatine solution, cooled to 20°C, and dried to obtain 101.5 kg of finished product with a yield of 77.48%.

Embodiment 3

[0019] Put 300 kg of water in a 1000L stainless steel reactor with stirring, heating, and reflux devices, then add 117 kg of N-methylguanidinoethanol, and add 435 kg of MnO under stirring. 2 , and then heated up to the temperature in the kettle at 95°C, and continued to react for 16 hours, ended the reaction, filtered while hot to obtain a creatine solution, cooled to 20°C, and dried to obtain 115.1 kg of finished product with a yield of 87.86%.

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PUM

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Abstract

The invention discloses a synthetic method of kreatine. The synthetic method of kreatine comprises the following steps: adding water in a stainless steel reaction kettle with a stirring, heating and refluxing device, then adding N-methylguanidine ethanol, adding manganese dioxide in stirring, next heating to be in-kettle temperature and reacting continuously, finishing the reaction, filtering immediately to obtain a kreatine solution, cooling to be 20 DEG C, filtering, and drying to obtain kreatine. Through the way, the invention can shorten the synthetic time, and the operation in the reaction process is simple.

Description

technical field [0001] The invention relates to the technical field of mechanochemical synthesis, in particular to a method for synthesizing creatine. Background technique [0002] Creatine, also known as N-methylguanidineacetic acid, β-methylguanidinoacetic acid, is a white powder crystal, odorless, slightly bitter taste; molecular formula: C 4 h 9 N 3 o 2 ; Molecular Weight: 131; Melting point 295°C, soluble in water, slightly soluble in cold water, insoluble in absolute ethanol, ether and acetone. [0003] Creatine is an amino acid derivative and a natural nutrient that exists in the human body. Creatine is synthesized in the liver, kidney, and pancreas in the human body. Creatine plays an important role in promoting the synthesis of nucleic acid and protein, increasing the reserve of energy substances in the body, promoting muscle growth, delaying fatigue and accelerating physical recovery. [0004] At present, the production and application of this product are paid...

Claims

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Application Information

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IPC IPC(8): C07C279/14C07C277/08
Inventor 王建峰任举司双喜温建华王敏文顾琦
Owner JIANGSU YUANYANG PHARMA
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