The invention discloses a
pioglitazone hydrochloride microneedle
drug delivery system for treating
type II diabetes and a preparation method of the
pioglitazone hydrochloride microneedle
drug delivery system. The
pioglitazone hydrochloride microneedle
drug delivery system comprises a pioglitazone hydrochloride hydrogel microneedle patch, an electric moistening gel patch and intelligent wearable equipment, the pioglitazone hydrochloride hydrogel microneedle comprises the following components in percentage by
mass: 0.5%-2.0% of pioglitazone hydrochloride, 12%-17% of a pioglitazone hydrochloride microneedle skeleton, 1%-2% of an auxiliary skeleton material, 0%-0.5% of a conductive material, 10%-20% of a glucose response material, 0.5%-1% of a fluorescent material and 57.5%-76% of
ultrapure water, the
electrowetting gel patch is divided into an inner layer and an outer layer, the inner layer is prepared from, by weight, 2.0%-5.0% of a gel framework material, 0%-0.5% of a conductive material and 94.5%-98% of
ultrapure water, and the outer layer is prepared from, by weight, 3%-12% of a matrix, 0.1%-0.5% of a cross-linking agent, 20%-60% of a
humectant, 1%-5% of a
tackifier, 2%-6% of an
excipient, 0.2%-0.8% of a cross-linking
regulator, 0.02%-0.08% of a complexing agent and 22%-58% of water. The intelligent wearable device is used for monitoring the blood glucose of the
human body, when the blood glucose level exceeds a preset threshold value,
drug release is accurately controlled through the
drug delivery module, and the treatment efficiency and safety are improved.