364 results about "Folate supplement" patented technology

The invention discloses collagen polypeptide firming and anti-wrinkle freeze-dried powder, and relates to the technical field of cosmetics. The invention relates to a biological preservative which is prepared from water, butanediol, a bacillus / soybean fermentation product extract, soluble collagen, acetyl hexapeptide-8, panthenol, 1, 2, 4-trimethyl-1, 3-pentanediol and a proper amount of water. The cosmetic is prepared from 1, 2-hexanediol, tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, tremella polysaccharide, saccharide isomeride, a bifidus yeast fermentation product lysate, sodium hyaluronate, DNA sodium, a radix gentianae extract, mannitol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-1, decapeptide-4, oligopeptide-3, hydrolyzed royal jelly protein, folic acid and disodium hydrogen phosphate. The additive is composed of sodium dihydrogen phosphate, citric acid and sodium citrate. The mask can provide rich nutrients for skin, deeply care the skin, moisturize and relieve the skin, tighten the skin, resist wrinkles and make the skin moisturized, glossy, elastic and tight, and is high in use safety and wide in application prospect.

The compositions comprise at least two ingredients selected from the group consisting of fish oil, L-arginine, vitamin E, vitamin C, vitamin B3, vitamin B5, vitamin B6, vitamin B1, vitamin B2, folic acid, biotin, vitamin B12, and are formulated for the prevention and / or treatment of a disease or condition associated with muscle decline in a subject in need thereof. Preferably, the subject in need is an individual at risk of or having renal failure, renal dysfunction or / and nephropathy, such as chronic nephropathy, protein energy consumption, end-stage nephropathy, renal failure due to hospitalization in an intensive care unit, acute kidney injury, and the muscle decline is selected from the group consisting of muscle depletion, muscle loss due to renal failure or dysfunction, muscle decline associated with chronic kidney disease, muscle loss due to hospitalization in intensive care units during renal failure, metabolic acidosis during chronic kidney disease, protein energy depletion, or a combination thereof. The method enables the prevention and / or treatment of at least one outcome of a disease or condition associated with muscle decline in a subject at risk of or having renal failure, renal dysfunction or / and kidney disease. The composition and the method can be used to improve the level of at least one amino acid.

The invention belongs to the field of food, and particularly relates to application of a nutritional composition for assisting in improving memory ability. The invention provides application of a nutritional composition in preparation of food for assisting in improving memory ability of offspring. The nutritional composition comprises the following necessary components: active folic acid substances and fucosyllactose, moreover, in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015): (0.5-10), the food is ingested by a mother to play the role of assisting in improving the memory ability of the offspring, the mother is in a gestation period and / or a lactation period, and the maternal is in the gestation period and / or the lactation period. The filial generation comprises a fetal-stage filial generation and / or an infant-stage filial generation and an optional child-stage filial generation. A large number of studies find that when active folic acid substances and fucosyllactose which are combined according to a certain proportion are supplemented to a mother at the beginning of the gestation period, the memory ability of offspring can be remarkably improved in an auxiliary mode.

The invention relates to the technical field of soybean milk products, in particular to application of a soybean folic acid enrichment method in soybean milk rich in folic acid. According to the method disclosed by the invention, a plant biotransformation technology is utilized, and folic acid in the soybeans is enriched by cleaning and soaking the soybeans, adding a substrate and a hypertonic substance and regulating and controlling the temperature and activating folic acid synthetase. The preparation method comprises the following steps: germinating soybeans for 24-36 hours, homogenizing, adding wheat germs and an additive, boiling the soybean milk, blending, homogenizing and sterilizing to obtain a stable healthy product with high folic acid content.

The invention discloses a feed for improving the flavor of broiler chickens and a preparation method of the feed, and belongs to the technical field of poultry feeds and feed preparation. Comprising the following components in parts by weight: 55 to 65 parts of basic ration, 35 to 40 parts of sea buckthorn pomace and bean dreg combined ferment, 3 to 5 parts of aquatic product leftover enzymatic hydrolysate, 3.5 to 4.0 parts of trehalose, 1.0 to 1.5 parts of ground cinnamon, 1.0 to 1.5 parts of xylooligosaccharide, 0.8 to 1.0 part of choline, 0.0001 to 0.0002 part of organic selenium and 0.01 to 0.02 part of folic acid. The mass ratio of the choline to the aquatic product leftover enzymatic hydrolysate is 1: (3.0-5.6); the mass ratio of the organic selenium to the sea buckthorn pomace and bean dreg combined fermentation product is 1: (58-100); the sea buckthorn pomace and bean dreg combined fermentation product is prepared by respectively pretreating sea buckthorn pomace and bean dregs and then carrying out aerobic, facultative and anaerobic continuous three-stage fermentation. The technical limitations that flavor substances of traditional feed are easy to inactivate and the utilization rate of agricultural by-products is low are broken through, and the breakthrough of flavor quality upgrading, efficient resource conversion and breeding benefit optimization is achieved.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The use of a nutritional composition in the preparation of a food product for assisting in improving the memory ability in offspring, wherein the nutritional composition contains the following essential components: an active folic acid substance and fucosyllactose; and in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015):(0.5-10). The food product exerts the effect of assisting in improving the memory ability in offspring, wherein the food product is ingested by a mother, the mother is preganant and / or lactating, and the offspring comprises fetal offspring and / or infant offspring and optionally childhood offspring.

The invention discloses a dendrobium officinale cold-resistant agent and application thereof. The active ingredient of the cold-resistant agent is folic acid and / or fulvic acid. Folic acid and fulvic acid are applied to cold-resistant treatment of dendrobium officinale for the first time, the innovation breaks through the limitation that a traditional cold-resistant agent is complex in component and possibly contains hormone or pesticide components, and a new, safer and more effective choice is provided for cold-resistant treatment of dendrobium officinale. The cold-resistant agent disclosed by the invention not only improves the survival rate of the dendrobium officinale in a low-temperature environment, but also remarkably reduces the damage degree of the appearance of the dendrobium officinale compared with a control group without using the cold-resistant agent, which shows that the cold-resistant agent disclosed by the invention has a remarkable effect on protecting the dendrobium officinale from low-temperature damage. The cold-resistant agent disclosed by the invention is simple in preparation process, easily available in raw materials and relatively low in cost, so that the cold-resistant agent has a wide application prospect in the fields of large-scale planting and deep processing of dendrobium officinale.

The present invention relates to a composition containing Citrus sinensis (L.) Osbeck fruit and lemon extracts and preferably a trace element, which is preferably a mineral such as Chromium, Calcium, Magnesium, Iron, Copper, Zinc, Iodine, Manganese, Potassium, Sodium, Selenium, Molybdenum, Fluoride, Chloride or Phosphorus or combinations thereof, and their salts and / or a vitamin such as A, D, E, K, B1, B2, C, Niacin, Pantothenic acid, B6, Folic acid, B12 or Biotin or combinations thereof.

The invention provides a folic acid quality control product prepared by using an alternative matrix, and belongs to the technical field of medical detection. The folic acid quality control product is prepared from 5-methyltetrahydrofolic acid, 5, 10-methylenetetrahydrofolic acid and a substitute matrix, the alternative matrix comprises bovine hemoglobin, L-ascorbic acid and a glycine-hydrochloric acid buffer solution (pH 3.0). The alternative matrix can meet the matrix effect requirement and can stabilize the 5-methyltetrahydrofolic acid and the 5, 10-methylenetetrahydrofolic acid for a long time, and the matrix components can be obtained from commercial ways and are low in cost, so that the folic acid quality control product provided by the invention can be widely applied to production and use of folic acid detection reagents or kits, and has wide application prospects. The folic acid detection kit has important significance on market popularization and application of the folic acid detection kit.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The invention discloses folate receptor mediated manganese ion coordination type cabazitaxel-loaded albumin nanoparticles as well as a preparation method and application thereof. Human serum albumin is covalently linked with folic acid through an amide condensation reaction to obtain a folic acid-albumin modifier with folic acid targeting; further combining with manganese ions through metal coordination to form a folic acid-albumin-manganese ion modifier with a targeting function; finally, efficient loading of cabazitaxel is achieved through a simple heating polymerization method, and the folate receptor mediated cabazitaxel-loaded albumin nanoparticles are formed. According to the nanoparticles provided by the invention, the particle size is about 140 nm, the stability is good, and the drug loading capacity and the encapsulation efficiency of cabazitaxel are high; the compound has a slow release effect, is good in in-vitro release behavior, and has important application value in the aspect of targeted delivery of drugs to tumors. Compared with other traditional nanoparticles, the nanoparticles show a remarkable anti-tumor effect.

The invention belongs to the field of food, and particularly relates to application of active folic acid substances to regulation of intestinal flora of a mother and a child. The invention provides an application of active folic acid substances in preparation of food which is taken by a mother and contributes to regulation of intestinal flora of the mother and offspring of the mother; wherein the active folic acid substances are selected from 6S-5-methyltetrahydrofolic acid and salts thereof, the mother is in a gestation period and / or a lactation period, and the offspring is in a fetal period, an infant period and / or a children period. The invention accidentally finds that the active folic acid substances are taken by the mother in the gestation period, so that the intestinal flora of the mother and the offspring can be obviously improved, and the active folic acid substances can promote the increase of beneficial bacteria in the intestinal tracts of the mother in the gestation period and the lactation period and the offspring of the mother and reduce the relative content of conditioned pathogens; furthermore, by adjusting the intestinal flora, the health of nervous systems of the mother and the offspring of the mother can be maintained through the intestinal brain axis.

The invention relates to the technical field of chemical synthesis of medicines, and particularly discloses a novel folic acid compound and application thereof, and the folic acid-containing compound has a structure as shown in a formula I or a formula II. The folic acid-containing compound can be used as a P-gp inhibitor, a chemotherapeutic drug sensitizer, a tumor metastasis inhibitor and a tumor multidrug resistance reversal agent. The folic acid-containing compound disclosed by the invention has good biological activity, excellent tumor multidrug resistance reversal activity and sensitization chemotherapy drug activity, the preparation method is simple, the yield is high, and the application prospect of folic acid and tetrahydroisoquinoline structures in the aspect of tumor multidrug resistance reversal agents is expanded. # imgabs0 #

The invention belongs to the technical field of biological medicines, and particularly relates to a nutritional composition as well as a preparation method, application and a product thereof. The nutritional composition provided by the invention consists of nicotinamide, B vitamins and a fungal polysaccharide compound, the vitamin B consists of vitamin B1, vitamin B2, vitamin B6, vitamin B12 and folic acid; the fungal polysaccharide compound is composed of a lucid ganoderma extract, a mushroom extract, an agaricus blazei murill extract, a hericium erinaceus extract, a coprinus comatus extract, a grifola frondosa extract and a cordyceps militaris extract. Western medicine source substances (nicotinamide and B vitamins) and traditional Chinese medicine source substances (fungal polysaccharide compounds) are combined, and the nutrition composition is prepared through combination of the Chinese medicine and the western medicine. The nutritional composition has remarkable effects of enhancing immunity, delaying senescence, resisting fatigue and resisting oxidation, and shows extremely wide application prospects in the field of preparation of health-care products, medicines and cosmetics.

The invention discloses a broad-spectrum combined medicine for treating liver cancer, which comprises purified water, tripterygium wilfordii alkaloid, tripterygium hypoglaucum alkaloid, chamaejasmine, gelsmium elegans alkaloid, xanthoxylin and various B medicines, and further comprises folic acid, vitamins, copper sulfate, zinc sulfate, manganese sulfate, yeast and penicillin sodium. Through the multi-component, multi-target and multi-path design, the medicine disclosed by the invention shows a potential effect of inhibiting the progress of liver cancer and good safety in cell experiments, animal models and human individual case observation. Cellular immunity and humoral immunity can be enhanced, the treatment cost is lower than that of a traditional treatment scheme, and no pain is caused during treatment.

The invention provides a capsule containing supramolecular anti-aging factors and used for improving ovarian functions and a preparation method of the capsule. The capsule is prepared from the following components by weight: 0.4 to 0.8 g of ergothioneine, 5 to 8 g of fruit polyphenol, 10 to 20 g of inositol composition, 5 to 8 g of diindolylmethane, 0.01 to 0.02 g of folic acid and 100 to 200 g of auxiliary materials. High-purity ergothioneine is extracted from pleurotus eryngii through microwave and ultrasonic combination, chiral inositol is extracted from tartary buckwheat seeds, the chiral inositol and myo-inositol are maintained to be in a proper proportion, meanwhile, fruit polyphenol and a small amount of folic acid are used in a matched mode, gelatin and other auxiliary materials are used for preparing a capsule form, the capsule is more convenient to take, the symptoms of premature ovarian failure can be relieved, and the effect of preventing and treating premature ovarian failure is achieved. The raw materials for preparing the capsule are environment-friendly, and the preparation process is simple and suitable for large-scale production.

The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a proteolipid composite supplement with synergistic hangover alleviating and liver protecting functions and a preparation method thereof. The health-care food comprises the following components in percentage by mass: 10-25% of a Pu'er tea extract, 15-30% of glucose syrup, 5-15% of a hovenia acerba extract, 5-15% of a radix puerariae extract, 8-20% of corn peptide, 5-15% of oyster peptide, 3-10% of earthworm peptide, 1-5% of malic acid, 2-8% of multivitamins, 1-5% of an electrolyte compound, 3-10% of prebiotic fibers and 0.5-3% of gamma-aminobutyric acid. The compound vitamins comprise B1, B2, B6, B12, folic acid and vitamin C; the electrolyte compound is a nanoscale electrolyte compound and is an organic chelate containing potassium, magnesium and zinc; the prebiotic fiber is prepared by compounding galactooligosaccharide and resistant dextrin; through compounding design of active peptide components, plant active ingredients and functional factors, the active peptide improves the activity of key enzymes in ethanol metabolism in a targeted manner, and alcohol decomposition is accelerated.

The invention provides a teak camel moth artificial feeding feed and a teak camel moth artificial feeding method, the feed comprises the following components by weight: 8% of wheat germ powder, 4% of soybean meal, 4% of yeast powder, 2% of casein, 2% of sucrose, 1.8% of agar powder, 1.5% of cellulose, 0.8% of Webster salt, 0.6% of vitamin C, 0.2% of sorbic acid, 0.3% of methyl p-hydroxybenzoate, 0.1% of cholesterol, 0.1% of choline chloride, 0.05% of inositol, 0.01% of folic acid, and the balance of water. And the balance of deionized water. The invention further provides an artificial feeding method of teak camelmoths, and the artificial feeding method comprises the steps of 1, adult mating and egg laying, 2, egg disinfection and incubation and 3, larva rearing. The feed does not contain host material teak leaves, and full-artificial continuous large-scale feeding of the teak camelmoths can be achieved.

The invention belongs to the field of biological medicine, and particularly relates to functionalized drug-loaded nanoparticles as well as a preparation method and application thereof. The macromolecule coupled folic acid modified quercetin-loaded mesoporous calcium carbonate nanoparticle T (at) QU (at) CaCO3 constructed by the invention not only can be used as a'calcium bomb 'to provide calcium ions for tumor calcium overload in a tumor slightly acidic environment, but also can be used for highly loading a traditional Chinese medicine anticancer active ingredient quercetin; besides, nanoparticles are wrapped based on polymer coupled folic acid modification, the stability of mesoporous calcium carbonate can be improved, irritation of quercetin can be reduced, in-vivo circulation can be enhanced, tumor cells can be further targeted based on folic acid modification, accumulation of drugs in TNBC cells can be promoted, and therefore the targeted delivery capacity is improved, and the purposes of effect enhancing and toxicity reducing are achieved. And a feasible scheme is provided for accurate targeted treatment of breast cancer, especially triple negative breast cancer.

The invention provides a nutrient composition. The nutrient composition is prepared from vitamin D, vitamin B6, folic acid substances and health-care food or medicine acceptable auxiliary materials. The composition has the advantages that the composition has a synergistic effect, can effectively shorten the sleep time, prolong the sleep time and improve the sleep quality, does not contain hypnotic components, has no toxic and side effects, does not generate dependence, is good in safety, can be eaten for a long time, and is easily accepted by people. In addition, the multi-component compound form of the product can significantly improve the compliance of users and save the total use cost.

The present invention provides a homocysteine-reducing composition that rapidly lowers blood homocysteine ​​levels to an appropriate level without causing any concerns about side effects. [Solution] A composition for reducing homocysteine ​​levels, comprising one or more B vitamins selected from vitamin B6, vitamin B12, and folic acid, and β-NMN as active ingredients. The β-NMN content is in the range of 22.32% to 89.29% by weight. Vitamin C and vitamin B2 may also be added.

The invention relates to a formula of a tea drink, and relates to the technical field of homology of medicine and food, and the formula is prepared by compounding nine components of double-petal red rose, Hetian jade jujube slices, dried mulberry, longan pulp, Ningxia wolfberry, Xinhui dried orange peel, raspberry, Hunan lotus seed pulp and licorice slices according to a specific proportion. Synergistic interaction is realized through triple action mechanisms, the liver soothing and depression relieving of the double-petal red rose is taken as a regulation and control core, the cortisol level is reduced, and endocrine imbalance is improved; on the basis of benefiting qi and nourishing blood by jujube slices and Chinese wolfberry fruits, dried mulberries and raspberries are enriched with natural folic acid and antioxidant substances, so that the egg cell quality and reproductive microcirculation are improved in a targeted manner; longan-Hunan lotus seed meat is used for warming uterus and tonifying spleen, and dried orange peel-licorice tablets are combined to enhance component absorption and compatibility stability. The preparation method comprises the steps of gradient drying, precise mixing and cobalt-60 irradiation sterilization. According to the scheme, the absorption bottleneck of traditional substitutional tea is broken through, the bioavailability is improved, and the compound sub-health problems of female endocrine disorder, follicular development disorder and cold uterus and weak body are quantitatively solved.

To provide development of health food supplements and antioxidants for controlling hyperuricemia and oxidative stress.SOLUTION: Embodiments of the disclosure include methods and compositions that comprise one or more herb extracts and optionally folic acid and / or one or more of its derivatives. In specific embodiments, the disclosure concerns treatment or prevention of hyperuricemic conditions with combinatorial compositions, such as those including one or more Chinese herbal medicine extracts and optionally folic acid and / or one or more of its derivatives.SELECTED DRAWING: None

The present invention provides a vitamin premix and a preparation process thereof, and belongs to the technical field of food additives, the preparation process is as follows: fat-soluble vitamin mixed particles, mixed water-soluble vitamins and mixed minerals are added into a mixer for mixing, then vitamin C, magnesium taurate, amino acids and tricalcium phosphate are added for continuous mixing, and sieving is performed to obtain the vitamin premix. Wherein the fat-soluble vitamin mixed particles comprise the following raw materials: vitamin A, vitamin E acetate, vitamin D3, vitamin K2, Arabic gum, modified protein and beta-cyclodextrin; the mixed water-soluble vitamins comprise the following raw materials: vitamin B1, vitamin B2, vitamin B5, vitamin B12, folic acid and nicotinamide; the mixed mineral substance comprises the following raw materials: ferrous glycinate, calcium citrate, magnesium citrate and zinc glycinate. The vitamin premix prepared by the invention can be used as a nutritional supplement in various foods, is convenient to use, and has good stability and mixing uniformity.

The present invention relates to a kit for determining folic acid and its metabolites in red blood cells by high performance liquid chromatography tandem mass spectrometry. The kit solves the problem of quantifying red blood cells by detecting the content of folic acid and its metabolites in red blood cells. The kit has a simple pretreatment process for the entire sample to be tested, high sensitivity, small sample volume, and strong specificity. Five types of folic acid and their metabolites in red blood cells can be simultaneously detected within 7.0 minutes. The kit can be used for clinical diagnosis of the five types of folic acid and their metabolites in red blood cells and health assessment.

The invention discloses a cascade seven-core optical fiber sensor applied to folic acid detection and a preparation method of the cascade seven-core optical fiber sensor, and belongs to the technical field of optical fiber sensing and biological analysis detection. The sensor comprises a first single-mode optical fiber, a seven-core optical fiber section and a second single-mode optical fiber, a double-microsphere-cavity structure is arranged at the optical fiber connecting position to form a cascade interference optical path, and tapering is conducted on the middle portion of the seven-core optical fiber section to form a sensing area. According to the invention, mode matching is improved through the microsphere cavity, an evanescent field is enhanced through tapering, and high-sensitivity specific detection of folic acid is realized in cooperation with the folic acid binding protein biological functional layer fixed on the surface; the sensor obtains stable linear response to a folic acid standard solution in the range of 0-50 ng / mL, a clinical serum sample verifies that the detection result of the sensor is highly consistent with that of a chemiluminescence method, the sensor has good reusability, and the sensor has the advantages of being easy to prepare in structure, rapid in response, high in sensitivity, capable of being matched with a complex matrix and the like, and has good application prospects. The method has huge potential in clinical folic acid quantitative detection.

The invention belongs to the technical field of food safety detection, and particularly relates to folic acid-o-phenylenediamine co-doped carbon quantum dots, an Escherichia coli O157: H7 detection probe, a detection reagent and application. The folic acid-o-phenylenediamine co-doped carbon quantum dots are prepared by heating folic acid and o-phenylenediamine to react. When the detection probe or the detection reagent based on the folic acid-o-phenylenediamine co-doped carbon quantum dots is used for detecting Escherichia coli O157: H7, the detection limit is low, the specificity is excellent, and the practicability is high.

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

The application belongs to the technical field of health products, and provides a growth-promoting amino butyric acid tablet and a preparation method thereof. 12 The preparation method of the amino butyric acid tablet is as follows: first, vitamin B1, vitamin B2, vitamin B6, vitamin B , vitamin D, folic acid and a first part of fillers are fully mixed and dried to obtain premix I; then, amino acids (gamma-amino butyric acid and L-lysine), the first part of premix I and a first part of binders are uniformly mixed; then, the remaining premix I is added and uniformly mixed to obtain premix II; then, calcium citrate, magnesium oxide, ferrous fumarate and sodium selenite are fully mixed, the remaining binders are dissolved in water and sprayed, wet granulation is carried out, and the granules are dried; finally, total mixing is carried out, and the tablet is pressed to be prepared. Through the improvement of the preparation process, the stability and content uniformity of B vitamins are improved, and the growth-promoting effect is improved.