204 results about "Folate supplement" patented technology

The invention belongs to the field of food, and particularly relates to application of a nutritional composition for assisting in improving memory ability. The invention provides application of a nutritional composition in preparation of food for assisting in improving memory ability of offspring. The nutritional composition comprises the following necessary components: active folic acid substances and fucosyllactose, moreover, in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015): (0.5-10), the food is ingested by a mother to play the role of assisting in improving the memory ability of the offspring, the mother is in a gestation period and / or a lactation period, and the maternal is in the gestation period and / or the lactation period. The filial generation comprises a fetal-stage filial generation and / or an infant-stage filial generation and an optional child-stage filial generation. A large number of studies find that when active folic acid substances and fucosyllactose which are combined according to a certain proportion are supplemented to a mother at the beginning of the gestation period, the memory ability of offspring can be remarkably improved in an auxiliary mode.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The use of a nutritional composition in the preparation of a food product for assisting in improving the memory ability in offspring, wherein the nutritional composition contains the following essential components: an active folic acid substance and fucosyllactose; and in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015):(0.5-10). The food product exerts the effect of assisting in improving the memory ability in offspring, wherein the food product is ingested by a mother, the mother is preganant and / or lactating, and the offspring comprises fetal offspring and / or infant offspring and optionally childhood offspring.

Various benefits to intestinal health are made by delivery of an active agent to the colon of an animal, including a human. Active ingredients include of riboflavin, vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, folic acid, β-carotene, vitamin B1, niacin, vitamin B5, vitamin B6, biotin, vitamin B12, omega-3 fatty acids and combinations thereof. Benefits include increased concentration of at least one short-chain fatty acid its salt thereof in the intestine, increased microbiome diversity in the intestine, increased beneficial bacteria in the intestine, increased the butyrate synthesis pathway in the intestine, improved barrier function of the intestine, reduced redox potential of the gut, reduced amount of gas produced in the intestine; and stimulation of intestinal immune responses.

The invention discloses folate receptor mediated manganese ion coordination type cabazitaxel-loaded albumin nanoparticles as well as a preparation method and application thereof. Human serum albumin is covalently linked with folic acid through an amide condensation reaction to obtain a folic acid-albumin modifier with folic acid targeting; further combining with manganese ions through metal coordination to form a folic acid-albumin-manganese ion modifier with a targeting function; finally, efficient loading of cabazitaxel is achieved through a simple heating polymerization method, and the folate receptor mediated cabazitaxel-loaded albumin nanoparticles are formed. According to the nanoparticles provided by the invention, the particle size is about 140 nm, the stability is good, and the drug loading capacity and the encapsulation efficiency of cabazitaxel are high; the compound has a slow release effect, is good in in-vitro release behavior, and has important application value in the aspect of targeted delivery of drugs to tumors. Compared with other traditional nanoparticles, the nanoparticles show a remarkable anti-tumor effect.

The invention discloses a broad-spectrum combined medicine for treating liver cancer, which comprises purified water, tripterygium wilfordii alkaloid, tripterygium hypoglaucum alkaloid, chamaejasmine, gelsmium elegans alkaloid, xanthoxylin and various B medicines, and further comprises folic acid, vitamins, copper sulfate, zinc sulfate, manganese sulfate, yeast and penicillin sodium. Through the multi-component, multi-target and multi-path design, the medicine disclosed by the invention shows a potential effect of inhibiting the progress of liver cancer and good safety in cell experiments, animal models and human individual case observation. Cellular immunity and humoral immunity can be enhanced, the treatment cost is lower than that of a traditional treatment scheme, and no pain is caused during treatment.

The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a proteolipid composite supplement with synergistic hangover alleviating and liver protecting functions and a preparation method thereof. The health-care food comprises the following components in percentage by mass: 10-25% of a Pu'er tea extract, 15-30% of glucose syrup, 5-15% of a hovenia acerba extract, 5-15% of a radix puerariae extract, 8-20% of corn peptide, 5-15% of oyster peptide, 3-10% of earthworm peptide, 1-5% of malic acid, 2-8% of multivitamins, 1-5% of an electrolyte compound, 3-10% of prebiotic fibers and 0.5-3% of gamma-aminobutyric acid. The compound vitamins comprise B1, B2, B6, B12, folic acid and vitamin C; the electrolyte compound is a nanoscale electrolyte compound and is an organic chelate containing potassium, magnesium and zinc; the prebiotic fiber is prepared by compounding galactooligosaccharide and resistant dextrin; through compounding design of active peptide components, plant active ingredients and functional factors, the active peptide improves the activity of key enzymes in ethanol metabolism in a targeted manner, and alcohol decomposition is accelerated.

The invention provides a teak camel moth artificial feeding feed and a teak camel moth artificial feeding method, the feed comprises the following components by weight: 8% of wheat germ powder, 4% of soybean meal, 4% of yeast powder, 2% of casein, 2% of sucrose, 1.8% of agar powder, 1.5% of cellulose, 0.8% of Webster salt, 0.6% of vitamin C, 0.2% of sorbic acid, 0.3% of methyl p-hydroxybenzoate, 0.1% of cholesterol, 0.1% of choline chloride, 0.05% of inositol, 0.01% of folic acid, and the balance of water. And the balance of deionized water. The invention further provides an artificial feeding method of teak camelmoths, and the artificial feeding method comprises the steps of 1, adult mating and egg laying, 2, egg disinfection and incubation and 3, larva rearing. The feed does not contain host material teak leaves, and full-artificial continuous large-scale feeding of the teak camelmoths can be achieved.

The invention belongs to the field of biological medicine, and particularly relates to functionalized drug-loaded nanoparticles as well as a preparation method and application thereof. The macromolecule coupled folic acid modified quercetin-loaded mesoporous calcium carbonate nanoparticle T (at) QU (at) CaCO3 constructed by the invention not only can be used as a'calcium bomb 'to provide calcium ions for tumor calcium overload in a tumor slightly acidic environment, but also can be used for highly loading a traditional Chinese medicine anticancer active ingredient quercetin; besides, nanoparticles are wrapped based on polymer coupled folic acid modification, the stability of mesoporous calcium carbonate can be improved, irritation of quercetin can be reduced, in-vivo circulation can be enhanced, tumor cells can be further targeted based on folic acid modification, accumulation of drugs in TNBC cells can be promoted, and therefore the targeted delivery capacity is improved, and the purposes of effect enhancing and toxicity reducing are achieved. And a feasible scheme is provided for accurate targeted treatment of breast cancer, especially triple negative breast cancer.

The present invention provides a homocysteine-reducing composition that rapidly lowers blood homocysteine ​​levels to an appropriate level without causing any concerns about side effects. [Solution] A composition for reducing homocysteine ​​levels, comprising one or more B vitamins selected from vitamin B6, vitamin B12, and folic acid, and β-NMN as active ingredients. The β-NMN content is in the range of 22.32% to 89.29% by weight. Vitamin C and vitamin B2 may also be added.

To provide development of health food supplements and antioxidants for controlling hyperuricemia and oxidative stress.SOLUTION: Embodiments of the disclosure include methods and compositions that comprise one or more herb extracts and optionally folic acid and / or one or more of its derivatives. In specific embodiments, the disclosure concerns treatment or prevention of hyperuricemic conditions with combinatorial compositions, such as those including one or more Chinese herbal medicine extracts and optionally folic acid and / or one or more of its derivatives.SELECTED DRAWING: None

The invention discloses a cascade seven-core optical fiber sensor applied to folic acid detection and a preparation method of the cascade seven-core optical fiber sensor, and belongs to the technical field of optical fiber sensing and biological analysis detection. The sensor comprises a first single-mode optical fiber, a seven-core optical fiber section and a second single-mode optical fiber, a double-microsphere-cavity structure is arranged at the optical fiber connecting position to form a cascade interference optical path, and tapering is conducted on the middle portion of the seven-core optical fiber section to form a sensing area. According to the invention, mode matching is improved through the microsphere cavity, an evanescent field is enhanced through tapering, and high-sensitivity specific detection of folic acid is realized in cooperation with the folic acid binding protein biological functional layer fixed on the surface; the sensor obtains stable linear response to a folic acid standard solution in the range of 0-50 ng / mL, a clinical serum sample verifies that the detection result of the sensor is highly consistent with that of a chemiluminescence method, the sensor has good reusability, and the sensor has the advantages of being easy to prepare in structure, rapid in response, high in sensitivity, capable of being matched with a complex matrix and the like, and has good application prospects. The method has huge potential in clinical folic acid quantitative detection.

The invention belongs to the technical field of food safety detection, and particularly relates to folic acid-o-phenylenediamine co-doped carbon quantum dots, an Escherichia coli O157: H7 detection probe, a detection reagent and application. The folic acid-o-phenylenediamine co-doped carbon quantum dots are prepared by heating folic acid and o-phenylenediamine to react. When the detection probe or the detection reagent based on the folic acid-o-phenylenediamine co-doped carbon quantum dots is used for detecting Escherichia coli O157: H7, the detection limit is low, the specificity is excellent, and the practicability is high.

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

The application belongs to the technical field of health products, and provides a growth-promoting amino butyric acid tablet and a preparation method thereof. 12 The preparation method of the amino butyric acid tablet is as follows: first, vitamin B1, vitamin B2, vitamin B6, vitamin B , vitamin D, folic acid and a first part of fillers are fully mixed and dried to obtain premix I; then, amino acids (gamma-amino butyric acid and L-lysine), the first part of premix I and a first part of binders are uniformly mixed; then, the remaining premix I is added and uniformly mixed to obtain premix II; then, calcium citrate, magnesium oxide, ferrous fumarate and sodium selenite are fully mixed, the remaining binders are dissolved in water and sprayed, wet granulation is carried out, and the granules are dried; finally, total mixing is carried out, and the tablet is pressed to be prepared. Through the improvement of the preparation process, the stability and content uniformity of B vitamins are improved, and the growth-promoting effect is improved.

The application discloses a folic acid composition, a folic acid patch and a preparation method thereof. The folic acid composition comprises folic acid, pressure-sensitive adhesive, a fatty compound and an alcohol compound; the fatty compound comprises a fatty acid and / or a fatty acid ester. The folic acid patch comprising the folic acid composition improves the bioavailability of folic acid, reduces the administration frequency, avoids the liver first-pass effect, has good folic acid penetration stability, and the folic acid content in the folic acid patch is basically unchanged after long-time placement.

The application provides an antitumor compound, an antitumor preparation and a preparation method thereof, and belongs to the technical field of medicines. The method comprises the following steps: (1) dissolving folic acid in water, adding an emulsifier and stirring to mix uniformly, adding a dimethylformamide solution of cholesterol-hemisuccinic acid, dicyclohexyl carbodiimide and 4-dimethylaminopyridine dropwise, stirring to react, dialysis, freeze-drying, and preparing folic acid-cholesterol-hemisuccinic acid; (2) adding an antitumor compound, phospholipid and folic acid-cholesterol-hemisuccinic acid into tetrahydrofuran, rotating to evaporate into a thin film, hydrating, ultrasonicating, filtering through a microporous filter membrane, and obtaining liposomes; and (3) adding the liposomes into a PBS buffer solution, adding N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, stirring to activate, adding PD-L1 and iRGD, stirring to react, dialysis, freeze-drying, and preparing the antitumor preparation.

The invention discloses a method and a device for judging a blood folic acid deficiency boundary value by liquid chromatography-mass spectrometry in the technical field of medical detection. The method comprises the following steps: step 1, pre-treating a sample; step 2, UPLC-MS / MS detection is carried out; step 3, data calculation and verification; and 4, performing boundary value conversion and judgment. According to the method, the regression model is constructed by fitting experimental data, the boundary value of folic acid deficiency and edge deficiency detected by the liquid chromatography-mass spectrometry is defined, serum pretreatment and liquid chromatography are integrated through the developed micro-fluidic chip, the speed and accuracy of serum folic acid detection by the liquid chromatography-mass spectrometry are further improved, and the method is suitable for large-scale popularization and application. The clinical detection requirements are met, and the efficiency and accuracy of judging the folic acid nutritional status are improved.

The invention discloses a complement amplification folic acid optical fiber sensing system and a folic acid concentration detection method thereof. The sensing system comprises an excitation light source, an optical fiber sensing probe, a micro-fluidic plate, a nanogold rod amplification solution and a spectrograph, the excitation light source, the optical fiber sensing probe and the spectrograph are sequentially communicated, the optical fiber sensing probe is introduced into the micro-fluidic plate, the nanogold rod amplification solution is introduced into the micro-fluidic plate, and the nanogold rod amplification solution is introduced into the spectrograph. The optical fiber sensing probe is a folic acid receptor protein modified gold-plated film optical fiber, and the nanogold rod amplification solution is a folic acid modified nanogold rod solution. Under the participation of the gold nanoparticles, the optical fiber sensing probe realizes enhanced plasma resonance wavelength shift, so that the sensitivity of folic acid molecule detection is remarkably improved, folic acid in a solution can be quickly and directly measured, and the application range is wide.

1. The name of the design product: packaging box (Xinrunkang active folic acid multi-vitamin tablets). 2. The use of the design product: for packaging box. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The invention discloses an oral patch platform based on multi-mechanism synergy and micro-matrix controlled release and a preparation method thereof. The patch comprises core nutrients (such as iron, calcium, folic acid and zinc) and a synergistic nutrient system (such as vitamin C, vitamin D, vitamin B12 and copper), and the release kinetics of different nutrients are accurately regulated and controlled through a physically separated multi-cavity structure (such as a double-semicircular laminated sheet) or a unique hydrophilic-hydrophobic micro-matrix component design; the effects of synergistically promoting absorption, assisting metabolism or preventing antagonism are achieved. According to the invention, the first-pass effect of the liver is avoided through oral mucosa absorption, and the composition can be attached to multiple sites in the oral cavity, so that the absorption efficiency, the bioavailability and the supplement safety of target nutrients are remarkably improved, and the composition is suitable for developing a series of nutritional supplement products or medicine products.

The application provides a full-value pet can for maintaining bone health and a preparation method, which comprises the following raw materials in mass parts: chicken breast meat 15-20 parts, chicken skeleton 3-7 parts, chicken heart 2-6 parts, beef 1-5 parts, beef liver 2-5 parts, tuna 5-10 parts, starch 9-14 parts, vegetables 17-23 parts, EPA 3-7 parts, vitamin K1-3 parts, folic acid 1-2 parts, nicotinic acid 0.5-1 part, mineral 2-6 parts, plant fermentation extract 5-9 parts, plant enzymolysis extract 3-6 parts and water 50-60 parts. The full-value pet can can provide full-value nutrition for pet cats, is beneficial to maintaining the bone health of the pet cats, prolongs the can storage time, inhibits the breeding of bacteria on the bottle opening and in the bottle after the can is opened, and improves the edible safety and storage time after the can is opened.

The application relates to the field of biological medicine, and discloses application of folic acid in prevention, diagnosis and treatment of genetic, infectious or allergic diseases. The application finds that the folic acid can achieve the prevention and treatment effects on the genetic, infectious or allergic diseases by improving inflammation, regulating iron ion metabolism, correcting intestinal flora disorder, reducing liver / intestinal tissue damage, inhibiting expression of inflammatory factors and promoting expression of Nox2. Meanwhile, the application provides application of one or more of the folic acid, S100a8, S100a9, Nox2 and IFN-gamma as a diagnostic or auxiliary diagnostic marker of biliary atresia. Meanwhile, the application provides the folic acid or a derivative thereof, which is prepared into food, a nutritional preparation or a medicine and applied to children or adults, so as to achieve the purposes of preventing and treating biliary atresia, cholangitis, jaundice, infectious diseases, intestinal diseases and diseases caused by abnormal folic acid metabolism.

The invention relates to the technical field of skin care, and discloses a composition for improving skin aging and a preparation method and application thereof. The feed additive is prepared from the following raw materials in parts by mass: 18 to 30 parts of yeast extract, 18 to 30 parts of rhizoma curcumae longae extract, 12 to 25 parts of mixed herbal extract, 12 to 25 parts of linear aspartame extract, 5 to 15 parts of green tea extract, 0 to 4 parts of vitamin B3, 0 to 3 parts of vitamin B5, 0 to 2 parts of vitamin B7, 0 to 2 parts of vitamin B12, 0 to 1 part of vitamin B6, 0 to 1 part of vitamin B1, 0 to 1 part of vitamin B2 and 0 to 1 part of folic acid. The preparation method of the capsule preparation comprises the following steps: taking the raw materials according to the mass parts of the composition, and uniformly mixing to obtain an intermediate product; controlling the mass content of water in the intermediate product to be less than or equal to 5.0% And filling the intermediate product into a plant-based capsule shell. Human body trial feeding verifies that the composition can effectively improve skin cell metabolism, relieve inflammatory response, clear ROS and AGEs, inhibit melanogenesis, promote skin hydration and delay skin photoaging.

1. The name of the design product: packaging bottle (Feihumor mother folic acid essence water and oil series). 2. The use of the design product: used as a skin care product packaging bottle. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: design 1 front view. 5. Design 1 is designated as the basic design.

This invention relates to the field of nanomedicine delivery technology, and discloses a bishelled silica-paclitaxel nanocarrier system and its preparation method. The system comprises an ethane-bridged bishelled mesoporous silica carrier, paclitaxel loaded within the mesopores and intershell cavities, a bovine serum albumin layer covalently coated on the carrier surface, and folic acid targeting groups attached to the surface of the bovine serum albumin layer. Preparation utilizes a CTAB template and a tetraethyl orthosilicate / 1,2-bis(triethoxysilyl)ethane composite silicon source, undergoing staged hydrolysis-condensation, hydrothermal reconstruction, amination, paclitaxel adsorption, bovine serum albumin coupling, and folic acid modification. The bishell structure increases the drug loading space, the bovine serum albumin layer inhibits premature leakage under physiological conditions and promotes drug release in a glutathione environment, and folic acid modification enhances the uptake capacity of folate receptor-highly expressed tumor cells.

The invention discloses a cleaning care solution, the care solution comprises a functional component and an auxiliary component besides water, the mass ratio of the functional component to the auxiliary component is (1.0-3.0): (10-20), and the functional component comprises a polyamino acid polysaccharide condensate aqueous solution and folic acid. The cleaning care solution has the following functions: (1) the cleaning care solution is used for cleaning female vulva parts; (2) moisturizing the stratum corneum of the human body; (3) promoting proliferation of lactobacillus at the vulva part; and (4) inhibiting the growth of pathogenic bacteria and maintaining the micro-ecological balance of the vulva.

This invention discloses an oral liquid for middle-aged and elderly men to cleanse blood, protect the brain, and promote hair growth, as well as its preparation method, belonging to the field of functional health food technology. Each bottle contains 50ml net content, one bottle daily, and is free of eight major allergens. The ingredients include resistant dextrin, erythritol, DHA algal oil microcapsule powder, phosphatidylserine, natto freeze-dried powder, various medicinal and edible extracts, ginseng, vitamins, folic acid, and purified water. This invention upgrades a solid beverage into an easily absorbed oral liquid dosage form, which is rapidly absorbed, does not harm the stomach and intestines, and can cleanse blood vessels, purify blood, assist in regulating blood pressure, blood sugar, and cholesterol, prevent and intervene in Alzheimer's disease, improve memory, and promote hair growth and darkening. The production process is mature and stable, suitable for industrial production, and is specially designed for middle-aged and elderly men, making it safe for long-term consumption.

The invention belongs to the field of animal feed, and particularly relates to a feed composition for improving body functions of camels and nutritional effects of camel milk and application of the feed composition. The feed composition takes first-crop alfalfa hay as a basic raw material, contains corn flour, soybean meal, flax residues, oil sunflower residue powder, rose willow powder, sea-buckthorn powder, elaeagnus angustifolia powder, alhagi sparsifolia powder or peganum harmala powder, soybean grass powder and cistanche deserticola residue powder, and is further matched with a Chinese wolfberry extract and a ginkgo leaf extract to serve as a functional additive. The feed is suitable for the camels in the lactation period, can improve the immunity and oxidation state of the camels, and improves the content of immunoglobulin, amino acid, folic acid, taurine, unsaturated fatty acid and other components in the milk of the camels. The obtained camel milk is suitable for producing dairy products with nutrient enrichment value. The feed is natural in component source and good in palatability, and can be widely applied to the field of camel breeding.