38 results about "Folate supplement" patented technology

This invention relates to the field of pet care product technology, and discloses a pet oral care spray and its preparation method. The preparation method employs a low-temperature gradient stepwise dissolution process: glucose oxidase is pre-dissolved at low temperature to obtain pre-solution A; bovine colostrum powder and lactoferrin are dissolved at low temperature to obtain protein pre-solution B; honey, folic acid, and vitamin D3 are dissolved at room temperature to obtain excipient pre-solution C; lysozyme is added to protein pre-solution B and stirred to dissolve; then pre-solution A and excipient pre-solution C are combined sequentially, the pH is adjusted, and purified water is added to make up the volume; the mixture is filtered through a microporous membrane for sterilization, and then filled and sealed under inert gas protection. This preparation method effectively protects the biological activity of each active protein and enzyme, achieving a long shelf life without the need for additional chemical preservatives. The resulting spray does not contain irritating ingredients such as alcohol and menthol, and is suitable for improving stomatitis, inhibiting plaque and tartar, and alleviating halitosis in pets of all ages and breeds.

This invention discloses an oral liquid for middle-aged and elderly men to cleanse blood, protect the brain, and promote hair growth, as well as its preparation method, belonging to the field of functional health food technology. Each bottle contains 50ml net content, one bottle daily, and is free of eight major allergens. The ingredients include resistant dextrin, erythritol, DHA algal oil microcapsule powder, phosphatidylserine, natto freeze-dried powder, various medicinal and edible extracts, ginseng, vitamins, folic acid, and purified water. This invention upgrades a solid beverage into an easily absorbed oral liquid dosage form, which is rapidly absorbed, does not harm the stomach and intestines, and can cleanse blood vessels, purify blood, assist in regulating blood pressure, blood sugar, and cholesterol, prevent and intervene in Alzheimer's disease, improve memory, and promote hair growth and darkening. The production process is mature and stable, suitable for industrial production, and is specially designed for middle-aged and elderly men, making it safe for long-term consumption.

The present application relates to the technical field of nutritional supplement food, more specifically, to a double-protein balanced type of old-age nutritional supplement food and a preparation method thereof. The food comprises calcium, magnesium, zinc, iron, vitamin C, vitamin B6, vitamin E, vitamin B2, sodium selenite, nicotinamide, vitamin D3, vitamin A, vitamin B12, folic acid, vitamin B1 and vitamin K2. The present application is targeted at physiological characteristics and metabolic rules of middle-aged and old people, and scientifically proportioned various vitamins, minerals, essential fatty acids and antioxidant substances required by human body, so as to fully meet daily nutritional requirements of the middle-aged and old people and make up for insufficient dietary intake caused by decreased digestive and absorptive functions.

A composition for improving cognitive performance, enhancing mental clarity, increasing focus, and increasing physical and mental energy is disclosed. The composition includes sufficient amounts of Fermented Green Tea Extract, L Theanine, and Caffeine, Ashwagandha Extract, Black Pepper Extract, Huperzine, Fermented Alpha GPC / Citoline Matrix, Turmeric Root Extract, Lions Mane Extract, Ginkgo Biloba Powder Extract, Panax Ginseng Extract, Rhodiola Extract, Cognitive Probiotic Blend, Folic Acid, Vitamin D3, Vitamin C Powder, Vitamin B12, Vitamin B6, Pantothenic Acid, Vitamin B3 Crystalline Powder, Vitamin B2 Powder, Vitamin B1 HCL, and Biotin.

This invention provides a composition containing vitamins and minerals, comprising vitamin D, folic acid, vitamin B12, potassium, and excipients in specific proportions. The invention may also include vitamin B1 and vitamin B2. The components of this composition have a synergistic effect in preventing hypertension, particularly in preventing hypertension accompanied by elevated homocysteine ​​levels. Furthermore, this composition can also be used for targeted nutritional supplementation in specific populations.

This application proposes a traditional Chinese medicine composition and preparation method for treating atrophic gastritis of spleen deficiency and blood stasis type, involving the field of traditional Chinese medicine. It utilizes Bupleurum chinense, stir-fried Paeonia lactiflora, Citrus reticulata peel, Pinellia ternata, Codonopsis pilosula, Poria cocos, stir-fried Atractylodes macrocephala, prepared Glycyrrhiza uralensis, Agrimonia pilosa, and Curcuma zedoaria, and establishes a water extraction and decoction preparation process. A rat model of precancerous gastric lesions was established using MNNG combined with multiple factors. Normal control group, model group, folic acid group, and traditional Chinese medicine group were set up to observe the morphological and pathological changes of the gastric mucosa. The results showed that the traditional Chinese medicine composition can reduce gastric mucosal atrophy, inflammatory cell infiltration, and fibrous tissue hyperplasia, alleviate intestinal metaplasia, downregulate the expression of AKT and mTOR proteins in the gastric mucosa, and inhibit abnormal mucosal proliferation. Its effect is superior to that of folic acid, providing experimental evidence for clinical treatment.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

This invention discloses an S-estrol composition for delaying ovarian aging and its uses, relating to the fields of biomedicine and health products. The S-estrol composition for delaying ovarian aging comprises, by weight, the following components: 1-5 parts S-estrol, 2-8 parts soy isoflavones, 3-10 parts coenzyme Q10, 2-6 parts vitamin E, 4-12 parts vitamin C, 0.01-0.05 parts folic acid, 0.1-0.3 parts zinc source, 0.5-1.5 parts anti-aging protective agent, 50-80 parts carrier, and 10-15 parts purified water. This invention uses high-purity S-estrol as the core, combined with soy isoflavones, coenzyme Q10 and a variety of antioxidant nutrients in a scientific formulation to form a synergistic system for estrogen receptor signal regulation and antioxidant defense. By constructing a complex antioxidant network and introducing novel anti-aging protectants for synergistic effect, the activity of antioxidant enzymes tends to increase and the level of lipid peroxidation tends to decrease, thereby improving the oxidative stress state in ovarian cells as a whole.

The present application relates to a kind of drug composition for preventing and adjuvant therapy of Alzheimer's disease and preparation method thereof, belong to medical health technical field.The prescription of the drug composition prepared in the present application includes the following active ingredients, phosphatidylserine, pyrrole quinoline quinone, coenzyme Q10, curcumin, EGCG, alpha-lipoic acid, acetyl L-carnitine, magnesium threonate, vitamin E, folic acid and vitamin B12.The preparation method of the drug composition also includes the following steps: the product is loaded with energy by weak magnetic resonance equipment to the composition.The drug composition reaches the effect of antioxidation, anti-inflammation, improves cerebral blood flow and protects neuron by the synergistic effect of multiple functional components, so as to help slow down the progress of Alzheimer's disease.

This invention relates to the field of sports nutrition food technology, and discloses a multivitamin formula and its preparation method, comprising the following components in parts by weight: 1.8-2.2 parts of mannose oligosaccharide, 1.8-2.2 parts of galacose oligosaccharide, 9-11 parts of xylooligosaccharide, 6.5-7.5 parts of fructooligosaccharide, 8.5-9.5 parts of maltitol, 1.8-2.2 parts of erythritol, 2.8-3.2 parts of galacose-mannan, 1.8-2.2 parts of stachyose, 13-15 parts of inulin, 38-42 parts of resistant dextrin, 0.20-0.24 parts of vitamin C, 0.45-0.55 parts of silicon dioxide, 0.010-0.014 parts of vitamin B1, and vitamin B2. 0.005-0.007 parts, folic acid 0.0009-0.0011 parts, γ-aminobutyric acid 0.45-0.55 parts, tyrosine 3.8-4.2 parts, magnesium lactate 3.8-4.2 parts; This invention forms a complex prebiotic system by simultaneously adding eight kinds of dietary fiber / oligosaccharides: resistant dextrin, inulin, xylooligosaccharide, fructooligosaccharide, galactooligosaccharide, mannose, galactomannan, and stachyose, which comprehensively regulates the intestinal flora and promotes the production of short-chain fatty acids.

This invention belongs to the fields of pharmaceutical raw material preparation and compound preparation, specifically relating to a method for preparing calcium folinate. The method includes: irradiating folic acid in a solvent with low light intensity in the presence of a photocatalyst and hydrogen donor I to achieve a first-stage hydrogen transfer reduction; after the concentration of dihydrofolate in the system reaches its peak, adding hydrogen donor II for high-intensity irradiation to achieve a second-stage hydrogen transfer reduction; then stopping the irradiation and sequentially performing a formylation reaction and a calcium salt precipitation reaction to obtain calcium folinate. The method provided by this invention not only enables a one-pot reaction but also improves the yield of calcium folinate, showing broad application prospects.

This invention discloses a fluorescent molecule targeting the folic acid receptor, its preparation method, and its applications. This invention provides a compound as shown in formula (I), its pharmaceutically acceptable salt, or its tautomer. The compound of this invention can be used as a fluorescent contrast agent in near-infrared surgical navigation.

The present invention relates to orally administrated compositions suitable for supporting women with premenstrual syndrome, which compositions contain: a) stereoisomers of inositol that contribute to the normal function of the ovaries, specifically myoinositol and D-chiro-inositol in a ratio of myoinositol: D-chiro-inositol from 2:1 to 5:1; b) vitamins of the B complex that contribute to normalpsychological function, preferably folic acid and / or vitamin B2 and / or vitamin B6 and / or vitamin B12; c) osier extract and / or Rooibos extract that contribute in normal psychological function; d) N-acetylcysteine and e) one or more inactive excipients.

The application relates to the technical field of microbial culture medium, and discloses a chemical component limited culture medium for supporting growth of bifidobacterium and application thereof. The CDM comprises a carbon source, salts, amino acids, vitamins and water; the carbon source is selected from at least one of glucose, fructose, lactose, maltose and galactooligosaccharide, the salts comprise sodium acetate, potassium hydrogen phosphate, ammonium acetate, magnesium sulfate heptahydrate, ferrous sulfate heptahydrate, sodium chloride and manganese sulfate monohydrate, the amino acids comprise alanine, cystine, cysteine, tryptophan and asparagine, and the vitamins comprise pyridoxine hydrochloride, nicotinic acid, calcium pantothenate, thiamine hydrochloride, riboflavin, p-aminobenzoic acid, folic acid and biotin. The CDM of the application is a liquid culture medium, only comprises 21 definite components, is simple in components, convenient in preparation, and is high in universality, and can effectively support growth of bifidobacterium.

This invention belongs to the technical field of functional foods for mothers and infants, specifically relating to a maternal and infant health composition containing inactivated Akkermansia myxophilus. Constipation, anemia, and decreased immunity are common during pregnancy. The composition of this invention contains inactivated Akkermansia myxophilus, folic acid, iron, calcium, vitamin D, and DHA. This invention can improve constipation during pregnancy, prevent anemia, and promote fetal neural development by regulating immunity and supplementing key nutrients. The composition of this invention is stable at room temperature and can be formulated into powder or chewable tablets.

A composition for improving female health, sexual performance, and benefiting the gut-brain axis is disclosed. The composition includes sufficient amounts of Black Cohosh Extract 20:1, Black Pepper Pepper Extract (95% piperine), Korean Red Ginseng 8:1, Ginkgo Biloba Leaf 8:1, Horny Goat Weed Extract 8:1, Tribulis Terrestris vine 8:1, Avena Sativa Extract Seed 8:1, Pine Bark Extract 8:1, Muira Pauma Extract 8:1, Lemon Balm P.E. 4:1 (Melissa officinalis folium), Red Raspberry Leaf Extract 4:1, Damiana Leaf Extract 4:1, Butea Superba Root 8:1, Ashwagandha Extract 4:1, L-Arginine HCL Powder, L-Citrulline, a Probiotic Blend, TKA 200, Fermented Green Tea Extract with L-Theanine and Caffeine, Folic Acid, Zinc Aspartate, Vitamin E (D-alpha Tocopheryl Acetate), Vitamin D3, Vitamin C (Ascorbic Acid), Vitamin B12 (Methyl cobalamin), Vitamin B6 (Pyridoxine HCL), Pantothenic Acid (D-Calcium Pantothenate), Vitamin B3 Crystalline Powder (Niacinamide), Vitamin B2 Powder (Riboflavin), Biotin (D-biotin), Vitamin B1 HCl (Thiamine HCL).

The application belongs to the technical field of nutrition, and particularly relates to a special medical composition for pregnant women and a preparation method and application thereof. The composition comprises the following components: DHA in the form of phospholipid, active folic acid, vitamin B1, vitamin B2, vitamin B6, vitamin B1, vitamin A, vitamin D, vitamin C, nicotinic acid, pantothenic acid, calcium element, iron element and zinc element. The calcium element is derived from calcium carbonate, the iron element is derived from ferrous gluconate, and the zinc element is derived from zinc sulfate. The composition provided by the application can act on the key window before pregnancy and in the early pregnancy period, and actively perform nutrition storage and metabolism regulation by using high-bioavailability key nutrients such as DHA in the form of phospholipid and active folic acid, and combining specific proportions of B vitamins, vitamin C, vitamin A, vitamin D and minerals.

This invention provides a set of primers and their applications for detecting SNP loci related to early prediction and nutritional intervention of gestational diabetes mellitus. Using time-of-flight nucleic acid mass spectrometry, it can rapidly complete the genotyping of 20 SNPs in a single reaction well without involving probes, fluorescent labels, or gel electrophoresis. The detection is accurate, rapid, and cost-effective. The product of this invention can predict the risk of gestational diabetes mellitus at an early stage and guide individualized folic acid intervention to reduce the risk of gestational diabetes mellitus. At the same time, it can improve existing gestational diabetes mellitus, combining the combined use of early prediction and nutritional intervention for gestational diabetes mellitus.

The application relates to the technical field of organic synthesis, and discloses a method for continuously preparing folic acid through pipe reactor collision. High pressure of a pipe reactor is used to make sodium pyrosulfite and N-(4-aminobenzoyl)-L-glutamic acid and 2,4,5-triamino-6-hydroxypyrimidine sulfate homogeneously disperse, raw materials are fully dispersed under the condition of less aqueous solvent, high-speed flow generated by high pressure is used to make N-(4-aminobenzoyl)-L-glutamic acid, 2,4,5-triamino-6-hydroxypyrimidine sulfate and trichloroacetone collide to occur a cyclization reaction, and the problem that material reaction is insufficient due to folic acid deposition and wrapping is avoided; sodium carbonate solution is sprayed to the continuous collision liquid flow, loss of raw materials caused by local alkali hydrolysis of trichloroacetone is avoided, the purity and yield of folic acid crude product are significantly improved, and the amount of waste water is reduced. The whole preparation process is a closed pipeline and a closed container, odor volatilization is avoided to affect the operation space, automatic control is easy, and the method is suitable for industrial production.

This invention discloses a targeted, temperature-sensitive drug-loaded composite microsphere based on attapulgite, comprising primary drug-loaded composite microspheres and lauric acid. The primary drug-loaded composite microspheres include purified attapulgite, gypenosides, inulin, and folic acid. Gynostemma pentaphyllum saponins, inulin, and folic acid are adsorbed onto a mesoporous structure composed of purified attapulgite rod crystals. The surface rigid structure of the primary drug-loaded composite microspheres includes a large number of interlaced channels. Lauric acid is encapsulated within the surface rigid structure of the primary drug-loaded composite microspheres. The mass percentages of purified attapulgite, gypenosides, inulin, and folic acid are: 50-85 parts: 10-30 parts: 10-25 parts: 0.1-1 parts; the mass ratio of the primary drug-loaded composite microspheres to lauric acid is 1:2 to 1:3. This application not only enables temperature-controlled "on-off" drug release, significantly improving drug targeting and therapeutic precision, but also reduces the systemic toxicity of chemotherapy at its source, achieving highly efficient and low-toxicity synergistic therapy.

The application discloses a kind of vitamin mineral beverage, wherein the component content of each 1000kg drinking water is: vitamin A 300-400mg, vitamin C 50000-60000mg, vitamin D33.8-5mg, vitamin E 6000-8500mg, vitamin B1600-900mg, vitamin B2600-900mg, vitamin B6900-1500mg, vitamin B120.9-1.5mg, nicotinamide 6000-9000mg, biotin 16000-20500mg, pantothenic acid 2800-4400mg, folic acid 320-440mg, calcium carbonate 336000-560000mg, pyrophosphate iron 4500-6500mg, zinc oxide 4500-7500mg, selenium-rich yeast 16-20mg, copper citrate 4500-7500mg, manganese citrate 2000-4000mg, sweetener 150-200g, essence 200-300g, the application provides the vitamin and mineral substance needed by human body, solve the problem of insufficient vitamin mineral intake, prevent deficiency, improve immunity, achieve the effect of nutrition and health care.

The application belongs to the technical field of electrochemical sensors, and particularly relates to an electrochemical immunosensor for high-sensitivity detection of folic acid as well as a preparation method and application thereof. The application introduces FBP as a specific recognition element into a folic acid detection system for the first time. Compared with a traditional immunosensor based on an antibody, the system innovatively utilizes high affinity and specific binding characteristics between FBP and folic acid, constructs a sensing interface with dual functions of molecular recognition and electrochemical signal conversion by modifying FBP on the surface of an AuNFs / SNC electrode. Experimental results show that the sensor presents excellent response characteristics for FA in a linear range of 1-100 nM, and the detection limit is as low as 0.33 nM (S / N=3).

The application provides a method for predicting volatile substances in breast milk and mother's diet and application thereof, comprising: obtaining diet information of a mother, performing nutrition element calculation on the diet information, inputting a prediction model, and predicting the content of volatile substances in breast milk; obtaining volatile substances in breast milk, inputting the prediction model, and predicting the diet information of the mother; the prediction model is obtained by using single factor variance analysis and multivariate linear regression analysis; wherein the volatile substances in breast milk include one or more of caprylic acid, 4-octanone, ethyl caprylate, nonanal, ethylbenzene and decane; and the mother's diet includes one or more of protein, fat, dietary fiber, cholesterol and folic acid. The volatile components in breast milk are separated by using HS-SPME-Arrow for the first time, and combined with chemometrics, so that the change of volatile flavor substances in breast milk can be rapidly and accurately detected.

The application discloses a kind of construction methods of diabetic nephropathy combined with acute kidney injury rabbit comorbidity model, it is related to biological medicine technical field, the construction method includes the following steps: rabbit is fed with high-fat high-sugar feed, then injection tetraoxypyrimidine, constructs type 2 diabetes rabbit model, continue to feed high-fat high-sugar feed, detect rabbit blood sugar, blood fat and urine albumin / creatinine ratio, carries out pathological examination of kidney tissue, determines whether the diabetic nephropathy rabbit model is established successfully, to the diabetic nephropathy rabbit model that is successfully constructed injection folic acid-sodium bicarbonate solution, detect blood urea and creatinine level, carry out pathological examination of kidney tissue, determine whether the diabetic nephropathy combined with acute kidney injury rabbit comorbidity model is successfully constructed.The application provides effective animal model for the pathogenesis and new treatment target of diabetic comorbidity, effectively solves the problem that single animal model cannot comprehensively reflect complex disease and the influence of drug side effects on experimental animals.

This application relates to the field of biomedical technology, specifically disclosing an immune-boosting preparation that promotes HPV viral genome methylation. The preparation comprises epigallocatechin gallate, folic acid, vitamin C, vitamin E, zinc gluconate, various B vitamins, and excipients. Its preparation method involves pretreatment of the raw materials and excipients, microencapsulation of some vitamins, staged mixing via gradient shearing, dry granulation, low-temperature vacuum staged drying, and granulation to produce an oral solid dosage form. This preparation can be used to intervene in HPV infection, achieving dual intervention by promoting HPV viral genome methylation and enhancing the body's immunity. It has the advantages of a rational formulation and stable active ingredients; its preparation process effectively avoids oxidative inactivation of active ingredients, ensuring the uniformity of the preparation, and is simple to operate, suitable for large-scale production, and can meet the needs of clinical and routine HPV infection intervention.

The present application belongs to the technical field of veterinary nutritional supplements or feed additives, and particularly relates to a rumen-protected folic acid preparation, a preparation method thereof and application thereof in improving lactation performance of ruminants. The rumen-protected folic acid preparation prepared by the present application is double-coated, and the degradation rate thereof in the rumen can be as low as 12.5% in 12 hours, and the release rate thereof in the small intestine can be as high as 71.7%, effectively solving the technical problem that more than 95% of ordinary folic acid is degraded in the rumen, and significantly improving the absorption and utilization rate of 5-methyltetrahydrofolic acid (5-MTHF) in the small intestine. In addition, ordinary folic acid needs to be reduced by dihydrofolic acid reductase (DHFR) and methylene tetrahydrofolic acid reductase (MTHFR) in two steps to generate active 5-MTHF, and the metabolic efficiency is limited; the present application directly supplements 5-MTHF, bypasses the metabolic bottleneck, and has a more direct and efficient effect, and thus can significantly improve the lactation performance and milk quality of ruminants.

The application provides a red blood cell five-methyl tetrahydrofolic acid level prediction system, utilizes complete red blood cell folic acid clinical data to establish a half-life increment parameter library and a genotype correction coefficient parameter library, calls matched prediction half-life increments and genotype correction coefficients through individual drug use parameters of a to-be-tested object, calculates the current red blood cell folic acid level, and determines whether a standard is reached according to a prediction result and gives an abnormal index and adjustment suggestions, so as to provide data support for folic acid supplement guidance and disease risk prevention and control.

The application provides a soft candy preparation process capable of preventing black flocculent matter from being precipitated and prepared soft candy, and solves the problem of black flocculent matter in the production process of multi-vitamin soft candy, improves product quality and production efficiency. Through the embedding folic acid process, folic acid is subjected to embedding treatment, direct contact between folic acid and other components is isolated, and the possibility of black flocculent matter caused by adverse reaction between folic acid and VC and other components in the production process is greatly reduced. Meanwhile, a perfect pouring head cleaning process is used, pre-cleaning and chemical cleaning before production, real-time cleaning in the production process, and deep cleaning after production are combined, the cleanliness of the pouring head is comprehensively ensured, the generation of black flocculent matter caused by impurities in the pouring head is avoided, and the problem of black flocculent matter in the production process of multi-vitamin soft candy is completely solved.

The present invention regards a combination or composition including epigallocatechin gallate (EGCG) and at least one other agent selected from folic acid, vitamin B12 and low or very low molecular weight hyaluronic acid (1-500 kDa), or derivatives, for the prevention, the control, and the treatment of a human papillomavirus infection in a subject.

A therapeutic composition comprising: L-arginine at 40% w / w; a branched-chain amino acid complex (BCAA) at 25% w / w, wherein the BCAA complex consists of leucine, isoleucine, and valine in a 2:1:1 ratio; L-glutamine at 15% w / w; myo-inositol at 10% w / w; one or more excipients containing fructose and flavorings at 10% w / w; and one or more micronutrients containing coenzyme Q10, folic acid, and zinc, or pharmaceutically acceptable salts thereof, in a total amount of less than 1% w / w, wherein the composition is configured to support cellular metabolism and reproductive function.