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Injection of 13 kinds complex vitamin and preparing technique thereof

A technology of complex vitamins and production process, which is applied in the field of vitamin preparations and achieves the effect of good stability

Inactive Publication Date: 2008-05-21
NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

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Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0045] First bottle:

[0046] Vitamin A 1 0.7g

[0047] Vitamin D 2 10mg

[0048] Vitamin E 7g

[0049] Vitamin K 1 0.2g

[0050] Vitamin C 80g

[0051] Niacinamide 17g

[0052] Vitamin B 2 1.4g

[0053] Thiamine 1.2g

[0054] Pyridoxine hydrochloride 1g

[0055] D-Panthenol 5g

[0056] Gentianolamine 40g

[0057] Tween 80 60g

[0058] Tween 20 1.9g

[0059] BHA 60mg

[0060] BHT 10mg

[0061] 20% Propylene Glycol 2.5L

[0062] Add water for injection to 4L

[0063]

[0064] Made 1000 pieces

[0065] Second bottle:

[0066] Biotin 20mg

[0067] Folic Acid 140mg

[0068] Vitamin B 12 1mg

[0069] 20% Propylene Glycol 100ml

[0070] Water for injection to 1L

[0071]

[0072] Made 1000 pieces

[0073] The preparation process is as follows:

[0074] The first bottle: According to the above amount, take Tween 80 and Tween 20 into a sterile container, ...

preparation example 2

[0077] First bottle:

[0078] Vitamin A 1 1g

[0079] Vitamin D 2 5mg

[0080] Vitamin E 10g

[0081] Vitamin K 1 150mg

[0082] Vitamin C 200g

[0083] Niacinamide 40g

[0084] Vitamin B 2 4g

[0085] Thiamine 6g

[0086] Pyridoxine hydrochloride 6g

[0087] D-Panthenol 15g

[0088] Gentianolamine 50g

[0089] Tween 80 70g

[0090] Tween 20 1.5g

[0091] BHA 100mg

[0092] BHT 30mg

[0093] 35% Propylene Glycol 1.5L

[0094] Add water for injection to 5L

[0095]

[0096] Made 1000 pieces

[0097] Second bottle:

[0098] Biotin 60mg

[0099] Folic Acid 600mg

[0100] Vitamin B 125mg

[0101] 35% Propylene Glycol 1.5L

[0102] Water for injection to 5L

[0103]

[0104] Made 1000 pieces

[0105] The preparation process is as follows:

[0106] The first bottle: take Tween 80 and Tween 20 in a sterile container, then add BHT, BHA, vitamin A ...

preparation example 3

[0109] First bottle:

[0110] Vitamin A 1 0.7g

[0111] Vitamin D 2 10mg

[0112] Vitamin E 7g

[0113] Vitamin K 1 0.2g

[0114] Vitamin C 80g

[0115] Niacinamide 17g

[0116] Vitamin B 2 1.4g

[0117] Thiamine 1.2g

[0118] Pyridoxine hydrochloride 1g

[0119] D-Panthenol 5g

[0120] Gentianolamine 40g

[0121] Tween 80 90g

[0122] Tween 20 1.0g

[0123] BHA 60mg

[0124] BHT 10mg

[0125] 10% Glycerin 1.2L

[0126] Water for injection to 4L

[0127]

[0128] Made 1000 pieces

[0129] Second bottle:

[0130] Biotin 20mg

[0131] Folic Acid 140mg

[0132] Vitamin B 12 1mg

[0133] 25% glycerin 300ml

[0134] Add water for injection to 1L

[0135]

[0136] Made 1000 pieces

[0137] The preparation process is as follows:

[0138] The first bottle: take Tween 80 and Tween 20 in a sterile container, then add BHT, BHA, vitamin A 1 , vitamin E, vitamin...

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Abstract

The invention discloses a preparation method and the production process of a complex injection of 13 vitamins. The injection adopts dual-injection type, the invention overcomes the problem of solubility of the fat-soluble vitamins in water, so the invention can be prepared into the water injection; the stability of the product is good, and various vitamins can not be affected mutually. The injection includes water-soluble vitamins, fat-soluble vitamins, surfactant, antioxidant, complexing agent and solvent, the injection water is added till the dissolution, the activated carbon is added for absorption, the pH value of the solution is regulated, and then the nitrogen filling and sterilization are carried out. The production process of the invention prepares the injection into dual-injection type, the vitamin B12, folic acid and biotin have an independent package, the process overcomes the problem of solubility of fat-soluble vitamins in water, the invention can be prepared into water injection, the stability of the product is good, and various vitamins can not be affected mutually, the vitamins can be added in a large infusion for usage, so as to avoid the trouble of redissolution and reuse of the freeze-dried powder injection.

Description

technical field [0001] The invention belongs to the field of vitamin preparations, more specifically, the preparation of multivitamin injections and the production process of the injections. Background technique [0002] Parenteral nutrition (PN) is widely used in the treatment of patients with the following diseases, such as congenital gastrointestinal malformations, moderate to severe malnutrition, gastrointestinal diseases, critically ill newborns who cannot eat normally, and severe neonates caused by radiotherapy and chemotherapy. Nutritional support for sick children with gastrointestinal reactions, stress consumption and perioperative patients. For patients who cannot eat through the digestive tract within a short period of time after surgery and have poor nutritional status, total parenteral nutrition support and appropriate supplementation of vitamins, amino acids, electrolytes, etc. can improve nutritional status, promote wound healing, and enable patients to recove...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61P3/02A61K31/07A61K31/122A61K31/16A61K31/355A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/592
Inventor 何盛江张现涛贾树田
Owner NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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