6 results about "Ethylone" patented technology

The application belongs to the field of medicine synthesis, and particularly relates to a preparation method of mesopram racemate. First, 1-(4-methoxy-3-propoxyphenyl) ethan-1-one, methyl triphenylphosphonium bromide and alkali are reacted in a solvent under inert gas protection to obtain a styrene intermediate I; then the intermediate I, a BocNCl2 reagent and an alkali reagent are reacted in a solvent to generate the mesopram racemate. The method provided by the application has the advantages of short steps, low cost, no metal residue and mild reaction conditions, and is suitable for industrial production.

This invention discloses a purification method for 2-bromo-1-(5-iodothiophene-2-yl)-ethyl ketone. Specifically, it includes the following steps: (1) slurrying crude 2-bromo-1-(5-iodothiophene-2-yl)-ethyl ketone in solvent A; (2) slurrying the product obtained in step (1) in solvent C; and (3) recrystallizing the product obtained in step (2) in solvent D. The purification method of this invention is simple and easy to implement, yields a product with high purity, and is suitable for industrial production.

Provided in the present invention is a preparation method for 1-[2-chloro-3-(bromomethyl)-4-(methylsulfonyl)phenyl]ethanone. A preparation method for 2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)benzoic acid of the present invention comprises: (1) in the presence of an initiator, subjecting 1-[2-chloro-3-(methyl)-4-(methylsulfonyl)phenyl]ethanone to a bromination reaction to obtain 1-[2-chloro-3-(bromomethyl)-4-(methylsulfonyl)phenyl]ethanone; (2) reacting 1-[2-chloro-3-(bromomethyl)-4-(methylsulfonyl)phenyl]ethanone to obtain 1-[2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)phenyl]ethanone; and (3) preparing 2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)benzoic acid from 1-[2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)phenyl]ethanone. The technical solution of the present invention has the advantages of involving few steps and achieving high yield, low cost and low energy consumption and the like, thus greatly reducing the production cost of tembotrione and tefuryltrione, and being more suitable for industrial production.

The application belongs to the technical field of organic synthetic chemistry, and particularly relates to a quinoxaline-2(1H)-selenone derivative, a preparation method and medical use thereof. The preparation method of the quinoxaline-2(1H)-selenone derivative is as follows: in an organic solvent, using o-phenylenediamine, aryl ethanone and selenium powder as raw materials, trimethylsilyl cyanide (TMSCN) as a reaction promoter, and performing a heating reaction under certain temperature conditions to obtain the quinoxaline-2(1H)-selenone derivative. The preparation method does not need to use a metal catalyst and a chemical oxidant, and has the advantages of simple operation, high yield and the like. The pharmacological activity test results show that the quinoxaline-2(1H)-selenone derivative provided by the application exhibits significant inhibitory activity on alpha-glucosidase, and has a broad application prospect in the preparation of drugs for preventing and / or treating type II diabetes, and has important significance for the development of drugs for diseases related to alpha-glucosidase mediation.

This invention discloses a method for synthesizing 2-perfluoroethylthio-1-aryl ethyl ketone, belonging to the field of organic chemistry. This method, under an O2 atmosphere, uses inexpensive and readily available arylethylene as a substrate, perfluoroethylthiosilver as the perfluoroethylthio source, and potassium persulfate as the oxidant to synthesize the 2-perfluoroethylthio-1-aryl ethyl ketone compound. This invention features broad substrate applicability, convenient operation, and yields a good amount of the target compound within 3-24 hours. The target compound has wide applications in pharmaceuticals, pesticides, and petrochemicals.