16 results about "Ethylone" patented technology

The application belongs to the field of medicine synthesis, and particularly relates to a preparation method of mesopram racemate. First, 1-(4-methoxy-3-propoxyphenyl) ethan-1-one, methyl triphenylphosphonium bromide and alkali are reacted in a solvent under inert gas protection to obtain a styrene intermediate I; then the intermediate I, a BocNCl2 reagent and an alkali reagent are reacted in a solvent to generate the mesopram racemate. The method provided by the application has the advantages of short steps, low cost, no metal residue and mild reaction conditions, and is suitable for industrial production.

The invention provides a phenolic compound with a hangover alleviating effect and a preparation method thereof. The structural formula of the polyphenol compound 1-(2, 4-dihydroxyphenyl)-2-(4-O-glucosylphenyl) ethanone is as shown in formula (I), and the polyphenol compound 1-(2, 4-dihydroxyphenyl)-2-(4-O-glucosylphenyl) ethanone is separated from pueraria thomsonii. In-vitro pharmacological experiments prove that the compound 1-(2, 4-dihydroxyphenyl)-2-(4-O-glucosyl phenyl) ethanone has good acetylcholin esterase inhibitory activity, and the EC50 value of the compound 1-(2, 4-dihydroxyphenyl)-2-(4-O-glucosyl phenyl) ethanone is 0.41 + / -0.07 mM, which indicates that the compound 1-(2, 4-dihydroxyphenyl)-2-(4-O-glucosyl The polyphenol compound 1-(2, 4-dihydroxyphenyl)-2-(4-O-glucosylphenyl) ethanone is expected to be used as a lead compound to develop a novel alcohol effect dispelling and liver protecting medicine.

The application provides a preparation method of 2-aminoethyl-3-chloro-5-trifluoromethylpyridine hydrochloride, which comprises the following steps: S1: 2-acetyl-3-chloro-5-trifluoromethylpyridine is reacted with hydroxylamine and p-toluenesulfonyl chloride under alkaline conditions in a solution to obtain 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethylamino p-toluenesulfonate; S2: 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethylamino p-toluenesulfonate is reacted under alkaline conditions at low temperature in a solution to obtain 2-amino-1-(3-chloro-5-trifluoromethylpyridin-2-yl)ethanone; S3: 2-amino-1-(3-chloro-5-trifluoromethylpyridin-2-yl)ethanone is reduced by a reducing agent under the action of a catalyst in a solution, and finally salification is carried out to obtain 2-aminoethyl-3-chloro-5-trifluoromethylpyridine hydrochloride. The application has the beneficial effects that the total yield of three steps is 82%, the product purity is greater than 99%, the solvent can be recycled and reused, the reaction route is short, the reaction yield is high, the product purity is high, no special process is needed, and the application can be popularized in industry.

This invention discloses a purification method for 2-bromo-1-(5-iodothiophene-2-yl)-ethyl ketone. Specifically, it includes the following steps: (1) slurrying crude 2-bromo-1-(5-iodothiophene-2-yl)-ethyl ketone in solvent A; (2) slurrying the product obtained in step (1) in solvent C; and (3) recrystallizing the product obtained in step (2) in solvent D. The purification method of this invention is simple and easy to implement, yields a product with high purity, and is suitable for industrial production.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of 1-(5-methoxy-2, 3-dihydro-1, 4-benzodioxane-8-yl) ethanone. Comprising the following steps: cuprous cyanide and an initial raw material are added into N, N-dimethylformamide for nitrogen displacement, and the initial raw material is 5-bromo-8-methoxy-2, 3-dihydro-benzo [1, 4] dioxin or 5-chloro-8-methoxy-2, 3-dihydro-benzo [1, 4] dioxin; cooling after the reaction, adding ammonia water, extracting, combining organic phases, and purifying to obtain 5-cyano-8-methoxy-2, 3-dihydro-benzo [1, 4] dioxin; the preparation method comprises the following steps: reacting 5-cyano-8-methoxy-2, 3-dihydro-benzo [1, 4] dioxin with anhydrous tetrahydrofuran, dropwise adding a tetrahydrofuran solution of a methyl Grignard reagent, and reacting until no 5-cyano-8-methoxy-2, 3-dihydro-benzo [1, 4] dioxin exists; the method comprises the following steps of: extracting, concentrating and drying, and purifying to obtain the 1-(5-methoxy-2, 3-dihydro-1, 4-benzodioxane-8-yl) ethanone, namely the 1-(5-methoxy-2, 3-dihydro-1, 4-benzodioxane-8-yl) ethanone. The method has the advantages of easily available raw materials, stable process and simple operation. The method can be applied to isotope labeling synthesis of C13 and C14 compounds.

The invention discloses a functional polyimide yarn and a preparation method thereof, and relates to the field of fibers. When the functional polyimide yarn is prepared, amino-terminated hydrogen-containing silicone oil firstly reacts with 1-(3-allyl-2, 4-dihydroxyphenyl) ethanone, then reacts with 4, 4 '-oxydiphenylamine and 4, 4'-oxydiphthalic anhydride, is spun, and finally reacts with 4-pyridine methylsulfonyl chloride to prepare modified polyimide fibers; the preparation method comprises the following steps: carrying out surface treatment on yakwool, and then reacting the yakwool with 2-(diphenylphosphino) ethylamine, 2-bromo-1-[3, 5-di (tert-butyl)-4-hydroxyphenyl] ethanone and 4-(2-aminoethyl) pyridine in sequence to prepare modified yakwool; the modified polyimide fibers and the modified yakwool are subjected to surface treatment through a zinc acetate solution and then blended, and the functional polyimide yarn is prepared. The functional polyimide yarn prepared by the invention has good antibacterial and durable capabilities.

The present application relates to a kind of 4-(2,2,2-trifluoro-1-alkoxyethyl) phenol preparation method, it is suitable for process amplification, for industrial production, the feature of preparation method is that, including: step (1), with trifluoro-1-(4-hydroxyphenyl) ethanone as raw material, preparation intermediate A, and, step (2), intermediate A prepared in step (1) is dissolved or dispersed in alkanol B, reaction is carried out in the presence of basic substance, 4-(2,2,2-trifluoro-1-alkoxyethyl) phenol is prepared, the reaction temperature of the reaction is 50~80 DEG C, reaction time is within 3 hours.

Provided in the present invention is a preparation method for 1-[2-chloro-3-(bromomethyl)-4-(methylsulfonyl)phenyl]ethanone. A preparation method for 2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)benzoic acid of the present invention comprises: (1) in the presence of an initiator, subjecting 1-[2-chloro-3-(methyl)-4-(methylsulfonyl)phenyl]ethanone to a bromination reaction to obtain 1-[2-chloro-3-(bromomethyl)-4-(methylsulfonyl)phenyl]ethanone; (2) reacting 1-[2-chloro-3-(bromomethyl)-4-(methylsulfonyl)phenyl]ethanone to obtain 1-[2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)phenyl]ethanone; and (3) preparing 2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)benzoic acid from 1-[2-chloro-3-(trifluoroethoxymethyl)-4-(methylsulfonyl)phenyl]ethanone. The technical solution of the present invention has the advantages of involving few steps and achieving high yield, low cost and low energy consumption and the like, thus greatly reducing the production cost of tembotrione and tefuryltrione, and being more suitable for industrial production.

The application belongs to the technical field of organic synthetic chemistry, and particularly relates to a quinoxaline-2(1H)-selenone derivative, a preparation method and medical use thereof. The preparation method of the quinoxaline-2(1H)-selenone derivative is as follows: in an organic solvent, using o-phenylenediamine, aryl ethanone and selenium powder as raw materials, trimethylsilyl cyanide (TMSCN) as a reaction promoter, and performing a heating reaction under certain temperature conditions to obtain the quinoxaline-2(1H)-selenone derivative. The preparation method does not need to use a metal catalyst and a chemical oxidant, and has the advantages of simple operation, high yield and the like. The pharmacological activity test results show that the quinoxaline-2(1H)-selenone derivative provided by the application exhibits significant inhibitory activity on alpha-glucosidase, and has a broad application prospect in the preparation of drugs for preventing and / or treating type II diabetes, and has important significance for the development of drugs for diseases related to alpha-glucosidase mediation.

This invention discloses a rapid distillation apparatus and processing technology for 2-chloro-1-(1-chlorocyclopropyl)ethyl ketone, relating to the field of distillation apparatus technology. The invention includes a distillation vessel body, with a steam inlet pipe fixedly connected to the lower exterior of the body. A spray device for circulating distillation of 2-chloro-1-(1-chlorocyclopropyl)ethyl ketone is installed at the top of the body, and a steam outlet pipe is fixedly connected to the top of the body. Through the cooperation of a motor, a rotating shaft, a flower-shaped baffle, a vertical Z-shaped rod, a first layered frame, a connecting plate, a second layered frame, a first slot, and a second slot, the invention ensures that 2-chloro-1-(1-chlorocyclopropyl)ethyl ketone inside the first layered frame enters the second layered frame through the first slot, and a portion of the 2-chloro-1-(1-chlorocyclopropyl)ethyl ketone flows to the bottom of the distillation vessel body through the second slot, thus forming a dispersed flow state and ensuring rapid distillation of 2-chloro-1-(1-chlorocyclopropyl)ethyl ketone.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of 1-substituted-1H-pyrazole-5-methyl formate 13C. Comprising the following steps: reacting a raw material with a substituent group, palladium acetate, 1, 1 '-bis (diphenylphosphine) ferrocene, triethylamine, methanol and N, N-dimethylformamide, replacing with nitrogen for three times, and then introducing 13CO to react; extracting and combining organic phases, washing, drying, and carrying out column chromatography purification to obtain a compound 1-substituted-1H-pyrazole-5-methyl formate 13C; the raw material with the substituent group is 1-benzyl-5-bromo-1H-pyrazole, 2-(5-bromo-1H-pyrazol-1-yl)-1-phenylacetophenone or 2-(5-bromo-1H-pyrazol-1-yl)-N, N-dimethylacetamide, and the raw material with the substituent group is one or two or more selected from a group consisting of a group consisting of 1-benzyl-5-bromo-1H-pyrazole, 2-(5-bromo-1H-pyrazol-1-yl)-1-phenylacetophenone and 2 According to the method, self-made 13CO is used as a labeling precursor, isotope labeling steps are short, reaction conditions are mild, the yield is high, and the obtained product is single and free of isomerization and generation of impurities difficult to purify.

The invention discloses a method for selectively preparing an imidazo [1, 2-a] pyridine derivative by synergistically regulating rhodium catalysis through a solvent and alkali salt, which comprises the following steps: taking 2-aryl imidazo [1, 2-a] pyridine or substituted 2-aryl imidazo [1, 2-a] pyridine and alpha-chloro-aryl ethyl ketone or substituted alpha-chloro-aryl ethyl ketone as initial raw materials; the metal rhodium catalyst is used for catalyzing the carbon-hydrogen bond activation reaction to prepare the imidazo [1, 2-a] pyridine derivative, the reaction condition is mild, the selectivity and yield are high, the safety is high, and industrial production is facilitated; according to the invention, 2-aryl imidazo [1, 2-a] pyridine or substituted 2-aryl imidazo [1, 2-a] pyridine and alpha-chloro-aryl ethyl ketone or substituted alpha-chloro-aryl ethyl ketone are used as initial raw materials for the first time, a reaction is regulated and controlled by simultaneously adjusting a solvent and basic salt, and a formyl methyl imidazo [1, 2-a] pyridine compound or 6-aryl naphtho [1 ', 2': 4, 5-difluoro-2-pyridine-2-one or 6-aryl naphtho [1 ', 2': 4, 5-difluoro-2-pyridine-2-one is prepared from the same initial raw materials. According to the invention, different products of the 5, 5] imidazo [1, 2-a] pyridine compound are synthesized, and the application universality is increased.

The present invention provides a method for producing a 2-(ethylsulfonyl)-1-heteroaryl ethane-1-one compound, comprising reacting an alkyl magnesium halide with (methylsulfonyl) ethane to obtain (ethylsulfonyl) methyl magnesium halide, and reacting (ethylsulfonyl) with a heteroaryl carboxylic acid ester compound such as a substituted or unsubstituted 5-6-membered heteroaryl carboxylic acid alkyl ester or a substituted or unsubstituted fused bicyclic 9-membered heteroaryl carboxylic acid alkyl ester and the methyl magnesium halide is subjected to chemical reaction.

This invention discloses a method for synthesizing 2-perfluoroethylthio-1-aryl ethyl ketone, belonging to the field of organic chemistry. This method, under an O2 atmosphere, uses inexpensive and readily available arylethylene as a substrate, perfluoroethylthiosilver as the perfluoroethylthio source, and potassium persulfate as the oxidant to synthesize the 2-perfluoroethylthio-1-aryl ethyl ketone compound. This invention features broad substrate applicability, convenient operation, and yields a good amount of the target compound within 3-24 hours. The target compound has wide applications in pharmaceuticals, pesticides, and petrochemicals.

The invention discloses a preparation method of 1-(2-hydroxy-3-methoxyphenyl) ethanone, which sequentially comprises the following steps: carrying out esterification reaction on 5-bromo-2-methoxyphenol serving as a raw material and an acetylation reagent in a solvent to generate an intermediate I; carrying out Fries rearrangement reaction on the intermediate I in a solvent under the catalytic action of a catalyst to generate an intermediate II; and carrying out reductive hydrogenation reaction on the intermediate II in a solvent containing ammonium formate under the catalytic action of a palladium-carbon catalyst to generate 1-(2-hydroxy-3-methoxyphenyl) ethanone. According to the preparation method, raw materials are easy to obtain, dangerous reagents such as methyl lithium and methyl magnesium bromide which are high in price and not easy to store are not used, reaction conditions are mild, side reactions are reduced, operation is simple and easy to control, and the requirement for experimental equipment is not high; the intermediate and the product can be purified through the steps of extraction, reduced-pressure evaporation to dryness, solvent impurity removal, suction filtration, drying and the like, the purity of the target product reaches up to 99% or above, column chromatography and other methods which are inconvenient for industrial operation are not used for post-treatment of the whole route, and the method is simple, convenient and easy to implement.