Yinhuang powder injection for intravenous injection and its prepn process

A silvery yellow powder and injection technology, which is applied in the field of silvery yellow powder injection for intravenous injection, can solve problems such as difficult to achieve effective therapeutic dose, limited injection volume, limited muscle absorption capacity, etc., and achieves significant therapeutic effect and increased dosage , the effect of avoiding pain

Inactive Publication Date: 2003-02-26
李大鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Yinhuang injection can only be used for intramuscular injection. Due to the physiological and anatomical characteristics of muscles, intramuscular injection has relatively large limitations. Thereby directly affecting the therapeutic effect, moreover, the absorption capacity of muscles is limited, especially after the injection of traditional Chinese medicine preparations, there are problems such as pain at the injection site, local sclerosis, etc., so this preparation is rarely used clinically at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Take 0.125Kg of honeysuckle extract (calculated as chlorogenic acid) and 0.2Kg of Scutellaria baicalensis extract (calculated as baicalin), add appropriate amount of water and sodium hydroxide solution to dissolve, mix, add water for injection to adjust the concentration to 1:5-1 : 10, adjust the solution to neutral, add an appropriate amount of activated carbon, heat and keep boiling slightly for 15-20 minutes, cool, filter, fill the filtrate in a glass bottle, sterilize, refrigerate for one week, and filter the liquid medicine under sterile conditions , to obtain the semi-finished product of Yinhuang powder injection, the semi-finished product is adjusted to near neutrality with sodium hydroxide solution, pressurized through a G3 vertically soluble glass filter, and filtered through a 0.65 μm microporous membrane, and the filtrate is dried by spray drying to obtain a dry powder. Packed in bottles and sealed for use.

Embodiment 2

[0012] Take 0.125Kg of honeysuckle extract (calculated as chlorogenic acid) and 0.2Kg of Scutellaria baicalensis extract (calculated as baicalin), add appropriate amount of water and sodium hydroxide solution to dissolve, mix, add water for injection to adjust the concentration to 1:5-1 : 10, adjust the solution to neutral, add an appropriate amount of activated carbon, heat and keep boiling slightly for 15-20 minutes, cool, filter, fill the filtrate in a glass bottle, sterilize, refrigerate for one week, and filter the liquid medicine under sterile conditions , to obtain the semi-finished product of Yinhuang powder injection, the semi-finished product is adjusted to near neutrality with sodium hydroxide solution, pressurized through a G3 vertically soluble glass filter, and filtered through a 0.65 μm microporous membrane, and the filtrate is dried by spray drying to obtain a dry powder. Packed in bottles and sealed for use.

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PUM

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Abstract

The present invention discloses a Yinhuang powder injection for intravenous injection and its preparation process. The formula includes honeysuckle extractive in 0.1-0.3 weight portions and skullcap root extractive in 0.1-0.6 weight portions. The preparation process includes the steps of dissolution of honeysuckle extractive and skullcap root extractive in water solution of sodium hydroxide, heating to slightly boiling for 15-20 min, filtering, disinfection, refrigerating for one week, pressurized filtering, freeze drying or spray drying for the filtrate liquid to obtain the said powder.

Description

technical field [0001] The invention relates to the technical field of silver yellow powder injection for intravenous injection. Background technique [0002] "Yinhuang" preparation is made by extracting and processing honeysuckle and Scutellaria baicalensis. It is used for fever, cough and sore throat caused by wind-heat attacking the lungs. For upper respiratory tract infection, acute tonsillitis and pharyngitis, see the above symptoms All of them have good curative effect, and there is a large clinical demand. [0003] At present, Yinhuang preparations include injections, oral liquids, oral granules, tablets, buccal tablets, aerosols, etc. Due to the rapid onset and obvious therapeutic effect of injection administration, there is also a great demand for injection preparations in clinical practice. The existing Yinhuang injection can only be used for intramuscular injection. Due to the physiological and anatomical characteristics of muscles, intramuscular injection has g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P11/04A61P11/14A61P29/00A61P31/00
Inventor 李大鹏梁泓李思
Owner 李大鹏
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