11 results about "Oral Granules" patented technology

The invention relates to the technical field of medicines, and relates to acetylcysteine anhydrous swallowing granules and a preparation method thereof. The acetylcysteine water-free swallowing particle disclosed by the invention is composed of a drug-loading particle and a taste-modifying particle. The drug-loaded particles comprise the following components in percentage by weight: 50.0-95.0% of acetylcysteine, 0.5-20.0% of adhesive and 0-49.5% of filler, the adhesive is selected from a low-melting-point adhesive, the filler is selected from a low-melting-point adhesive, the filler is selected from a low-melting-point adhesive, and the adhesive is selected from a low-melting-point adhesive, a high-melting-point adhesive, a high-melting-point adhesive and a high-melting-point adhesive. The low-melting-point adhesive is preferably selected from one or a mixture of more than two of lauric acid polyethylene glycol glyceride, glyceryl monostearate and glyceryl distearate, polyethylene glycol 4000 and polyoxyethylene 40. The acetylcysteine water-free swallowing granules prepared by the invention are convenient to carry, can be rapidly disintegrated in the oral cavity and rapidly release medicines, enter gastrointestinal tracts along with swallowing actions to be absorbed, and do not need to be swallowed by water; the preparation is good in medicine taking compliance, stable in quality, rapid in effect taking and convenient to take.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a lipid-lowering prescription and application thereof, compound lipid-lowering granules and a preparation method and application thereof. The lipid-lowering prescription comprises nine medicinal materials, namely polygonum multiflorum, ginseng, astragalus membranaceus, hawthorn, rhizoma alismatis, eucommia ulmoides, ligusticum wallichii, semen cassiae and oriental wormwood. The lipid-lowering prescription disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, excreting dampness and promoting diuresis, clearing liver and tonifying kidney, and relaxing bowel, and has the potential to be clinically used for treating hyperlipemia and preventing atherosclerotic plaque. According to the invention, the preparation method is optimized, so that about 8g of the compound lipid-lowering granules are orally taken three times a day and 1-2 bags of the granules are orally taken each time on the premise that the daily dose of crude drugs is not changed. And the dosage is greatly reduced. In addition, the compound lipid-lowering granules are beneficial to long-term administration by patients, and are convenient to carry and store. Researches in the aspects of pharmaceutics, pharmacodynamics, toxicology, quality control, stability and the like prove that the compound lipid-lowering granules prepared by the preparation method disclosed by the invention are stable in quality, safe and effective.

The invention discloses a multi-target anticancer composition based on space-time controlled release and synergistic effect and a preparation method thereof, the composition is composed of three oral granules with synergistic functions: immune basic granules used for establishing an immune barrier; the targeted controlled-release particles are used for targeted release of the CD47 inhibitor and the flora prodrug in the intestinal tract; the space-time programming particle is used for carrying out in-vivo epigenetic editing under light control. Through dosage form design and a multi-level controlled release technology, time sequence and space precise treatment under oral administration is achieved, the medicine has the advantages of being high in synergy, high in targeting performance, good in safety and good in patient compliance, and a brand new solution is provided for radical treatment of cancers.

The application discloses a quality detection method of Yinxie No.1 oral granules, and relates to the field of traditional Chinese medicine analysis. The method adopts a thin layer chromatography method to identify Sophora flavescens, Glycyrrhiza uralensis, Arctium lappa and Saposhnikovia divaricata, and simultaneously adopts a high performance liquid chromatography method to detect the content of paeoniflorin, so that the quality of the Yinxie No.1 oral granules is comprehensively evaluated and controlled, a comprehensive and reliable basis is provided for the authenticity identification and internal quality detection of the granules, and the stability of product quality and the safety and effectiveness of clinical medication are ensured.

The present invention discloses a medicine and food homologous composition for conditioning pain according to syndrome differentiation and its preparation method, belonging to the technical field of medicine and food homologous health products. The composition includes a general basic pain-relieving formula and special formulas for three syndromes, namely qi stagnation and blood stasis type, cold-dampness obstruction of collaterals type, and liver-kidney deficiency type. It follows the compatibility of monarch, minister, assistant, and envoy, and accurately adapts to more than 80% of the population with neck, shoulder, waist, and leg pain. The general formula is used for basic pain-relieving conditioning, and the three special formulas respectively achieve targeted conditioning of promoting blood circulation to remove blood stasis, warming meridians to dispel cold, and tonifying the liver and kidney to strengthen tendons and bones for the corresponding syndromes; the preparation methods are divided into two categories: oral administration (granules, powders, tablets) and external hot compress packs, and the process is standardized and can be scaled up; the product has been tested with a total effective rate of ≥96.7%, is safe without side effects, has high stability, realizes syndrome differentiation and conditioning, and accurate pain relief, and can be directly used for the conditioning and prevention of neck, shoulder, waist, and leg pain.

The invention relates to the technical field of pharmaceutical preparations, in particular to a melogabalin besylate pharmaceutical composition and a preparation method thereof. The melogabalin besylate gel comprises melogabalin besylate based on melogabalin, a hydrophilic polymer carrier (HPMCP or HPMCAS), a surfactant and colloidal silicon dioxide. The medicine, the carrier and other components are prepared into a solid dispersion by adopting a hot melt extrusion technology. By optimizing a carrier and a process, the technical problems of low dissolution rate and high hygroscopicity of raw material medicines are solved, the dissolution rate of the obtained product exceeds 95% within 15 minutes, and the stability of the product in a high-humidity environment is remarkably improved. The composition is preferably an oral granule, is convenient for patients with dysphagia to take, has excellent bioavailability and patient compliance, is green and efficient in production process, and is easy for industrial production.

This invention relates to the field of pharmaceutical preparations, specifically providing anhydrous rimantadine hydrochloride granules and a method for preparing the same. The anhydrous rimantadine hydrochloride granules are a mixture of drug-containing taste-masked granules and flavor-correcting granules. The drug-containing taste-masked granules comprise rimantadine hydrochloride and a taste-masking material, wherein the taste-masking material is a lipid or waxy material. This invention, by selecting a lipid or waxy material as the taste-masking material and mixing it with rimantadine hydrochloride to prepare drug-containing taste-masked granules, and then mixing them with flavor-correcting granules, effectively masks the taste and allows for direct swallowing without water, greatly improving medication adherence, especially suitable for children, the elderly, and other individuals with swallowing difficulties. Furthermore, the preparation method of this invention is simple, requires minimal equipment, is low-cost, and suitable for large-scale production.

The invention discloses a plant compound preparation for relieving children cough and asthma and airway inflammation and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The preparation is prepared from a modified sophora flower bud extract, a fermented pericarpium citri reticulatae extract and a low-sensitivity tussilago farfara extract according to the weight ratio of 1: (3-4): (0.8-1.2), quercetin in the modified sophora flower bud extract is quantified to be 1.2%-2.0% through a high performance liquid chromatography method, and small molecule hesperidin in the fermented pericarpium citri reticulatae extract is quantified to be 2.5%-3.5% through a liquid chromatography-mass spectrometry method. The tussilagone in the low-sensitivity tussilago farfara extract is quantified to be 0.8%-1.5% through a gas chromatography-mass spectrometry method. A mild process is adopted for preparation, the preparation is an oral granule special for children, the dosage is fixed according to ages, the safety is high and the compliance is good through experimental verification, the cough and asthma recurrence rate is reduced through multi-target cooperation, and the pharmaceutical composition is suitable for children of 3-12 years old.

The invention belongs to the field of traditional Chinese medicine preparations, and discloses radix astragali and rhizoma atractylodis macrocephalae healing-promoting oral granules for regulating a chronic wound microenvironment, a preparation process of the granules and application of the granules in chronic wound treatment. The radix astragali and rhizoma atractylodis macrocephalae healing promoting oral granules are prepared from 25-35 parts of raw radix astragali, 10-20 parts of radix pseudostellariae, 10-20 parts of fried rhizoma atractylodis macrocephalae, 25-35 parts of radix salviae miltiorrhizae, 10-20 parts of fructus lycii and 10-20 parts of fructus corni through gradient ethanol extraction and astragaloside enrichment processes. According to the granules, systematic regulation of wound surface microenvironment steady state is realized in an oral dosage form for the first time, and triple pathological links of high glucose-infection-ischemia of chronic wound surfaces are synchronously improved through a synergistic effect of a dogwood fruit pulp blood glucose reducing component and a high-proportion astragalus membranaceus / salvia miltiorrhiza healing promoting component; clinical tests show that when the oral granules are singly used for treating the deep chronic refractory ulcer, the healing time is shortened by 32% compared with that of red ointment, and the healing rate is increased to 76.3%.

The invention discloses a preparation method and application of a traditional Chinese medicine spray for treating asthma, and belongs to the technical field of traditional Chinese medicine preparations. The stability problem of the traditional Chinese medicine spray is systematically solved through the synergistic effect of alcohol precipitation impurity removal, volatile oil clathration, pH regulation and control and the ternary stabilizer. Pharmacodynamic studies show that the spray can remarkably reduce the inflammatory factor level of asthma model mice and prolong the incubation period of asthma inducing of guinea pigs, has the effect better than that of oral granules, takes effect quickly and is suitable for quick relief in the acute attack period of asthma.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating neuropathic pain and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from ligusticum wallichii, radix angelicae, asarum, scorpio, caulis spatholobi and sargentgloryvine stem. The preparation method comprises the following steps: taking medicinal materials; preparing scorpion extract fine powder; and carrying out water extraction and granulation. The invention provides an innovative compatibility for treating neuropathic pain by integrating various'collateral dredging methods' in one prescription, and the innovative compatibility is prepared into oral granules which are convenient to take. Animal experiments prove that the traditional Chinese medicine composition provided by the invention has a remarkable effect in the aspect of treating neuropathic pain, has no obvious side effect, and has potential clinical popularization and application values.