34 results about "Vidarabine Monophosphate" patented technology

The invention provides a phosphorylation method for preparing vidarabine monophosphate. The method is specifically as below: using vidarabine as a starting material; conducting phosphorylation on the material under the protection of inert gas and under the effect of catalyst; and conducting active carbon decoloration treatment to obtain a vidarabine monophosphate crude product. The process route is simple, low-cost and high-yield; and compared with the prior art, the production process has significantly reduced toxicity, and is suitable for process production.

The invention relates to a chitosan microsphere drug delivery system of vidarabine and a preparation method. The method is characterized by acquiring the the medicinal microsphere drug delivery system with a complete spherical shape, a uniform particle size, a high embedding rate, good dispersity and a sustained release property. The specific technical scheme is that: chitosan is taken as a membrane material, polyethylene glycol is adopted as a pore-forming agent, glutaraldehyde is employed as a crosslinking agent, and inverse emulsification-crosslinking method is used to prepare the drug carrying microspheres. The preparation method includes: dissolving the drug in an acidic aqueous solution of chitosan, adding polyethylene glycol and stirring them uniformly, and taking the mixture as an aqueous phase; adding the aqueous phase slowly into an oil phase containing a surface active agent and a dispersing agent, carrying out stirring and emulsifying to uniformity, and adding the crosslinking agent to undergo crosslinking solidification; and washing and drying the obtained product. The invention provides the vidarabine chitosan microsphere drug delivery system with a sustained-release property.