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Vidarabine monophosphate pharmaceutical composition

The technology of adenosine monophosphate and the composition is applied in the field of medicine, which can solve the problems of increasing the incidence of adverse drug reactions, increasing the medical cost of patients, etc., and achieves short freeze-drying time, stable product quality and short production cycle Effect

Inactive Publication Date: 2016-01-13
双鹤药业(海南)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Children's off-label dosage can easily increase the incidence of adverse drug reactions and increase the medical cost of patients

Method used

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  • Vidarabine monophosphate pharmaceutical composition
  • Vidarabine monophosphate pharmaceutical composition
  • Vidarabine monophosphate pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: specification A: 15mg prescription

[0027] Vidarabine Monophosphate 15g

[0028] Mannitol 6g

[0029] Appropriate amount of 10% sodium hydroxide solution

[0030] Water for injection 750ml

[0031]

[0032] Made 1000 pieces.

Embodiment 2

[0033] Example 2: Specification B: 20mg prescription

[0034] Vidarabine Monophosphate 20g

[0035] Mannitol 8g

[0036] Appropriate amount of 10% sodium hydroxide solution

[0037] Water for injection 750ml

[0038]

[0039] Made 1000 pieces.

Embodiment 3

[0040] Example 3: Specification C: 30mg prescription

[0041] Vidarabine Monophosphate 30g

[0042] Mannitol 12g

[0043] Appropriate amount of 10% sodium hydroxide solution

[0044] Water for injection 750ml

[0045]

[0046] Made 1000 pieces.

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Abstract

The invention relates to a vidarabine monophosphate pharmaceutical composition and a preparation method thereof. A low dose of the vidarabine monophosphate pharmaceutical composition is effective in treating herpesvirus infection or cytomegalovirus infection in children 0 to 14 years old, and the toxic and side effect and the increase in medical cost caused by a high-dose or ultrahigh-dose administering manner of 5-10 mg / kg reported in documents are avoided.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a low-dose adenosine vidarabine monophosphate pharmaceutical composition and a preparation method thereof. Background technique [0002] Vidarabine monophosphate is a monophosphate compound of vidarabine, which is a synthetic adenosine antiviral drug. At present, it is mainly used for chronic viral hepatitis, herpes simplex virus, herpes zoster virus, cytomegalovirus, vaccinia virus, various animal herpes viruses and a few carcinogenic RNA viruses in China. Vidarabine monophosphate has been listed in Europe, the United States, Japan and many other countries. Vidarabine monophosphate can selectively inhibit the activity of viral polymerase and nucleotide reductase, and has a broad inhibitory effect on DNA viruses. [0003] Most clinically used adenosine monophosphate dosage forms are injection dosage forms. Among them, water injections are widely used because of...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K9/19A61P31/22
Inventor 魏雪纹李强
Owner 双鹤药业(海南)有限责任公司
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