The invention discloses a scourge-clearing toxin-vanquishing traditional Chinese medicine composition for animals and its preparation method. The scourge-clearing toxin-vanquishing traditional Chinesemedicine composition for animals is prepared from, by weight, 10 parts of ephedra, 20 parts of honeysuckle 15 parts of Gardenia jasminoides, 15 parts of Codonopsis pilosula, 15 parts of radix rehmanniae, 15 parts of semen cuscutae, 10 parts of Scutellaria baicalensis, 10 parts of cortex moutan, 25 parts of gypsum, 15 parts of liquorice, 20 parts of lophatherum gracile, 16 parts of radix scrophulariae, 25 parts of fructus forsythia, 30 parts of rhizoma anemarrhenae, 20 parts of radix paeoniae rubrathe, 10 parts of Platycodon grandiflorum, 15 parts of isatis root, 2 parts of lotus plumule, 10 parts of radix angelicae, 10 parts of radix bupleuri, and 10 parts of almond. The preparation includes steps of material preparation; first immersion; secondary immersion; drug taking; stirring; package in bottle. Through analyzing cytomegalovirus infection by the view of traditional chinese medicine, the cytomegalovirus infection belongs to the liver-fire and internal depression, wind toxin infection, deficiency of spleen and kidney yin, phlegm toxic heat hysteresis; the traditional Chinese medicines for clearing heat and detoxifying, removing heat from the liver and activating blood, warmingand supplementing liver deficiency, relieving rheumatic pains and reducing phlegm are combined as the treatment drug and prepared to be injection drug; thus the shortcoming of difficultly feeding andeating traditional Chinese medicine is overcame, the effect is rapidly played, and the treatment effect is significant.