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Process For The Preparation And Use Of A Bivalent Vaccine Against Morphine-Heroine Addiction

The structural design, preparative methods and chemical composition of two structural formulations of bivalent vaccines against morphine-heroin addiction (morphine-6-hemisuccinyl-EDC-TFCS-tetanus toxoid and 3-O-carboxymethylmorphine-EDC-TFCS-tetanus toxoid), are disclosed. These vaccines are suitable for human use in which they are capable of triggering the synthesis of polyclonal antibodies against morphine opiate and its structural analogue, heroin, through the repeated in vivo administration of these formulations, in active vaccination protocols, in pre-clinical studies in rodents. The active vaccination paradigm through which these immunogens trigger a humoral immune response consolidated with a long-term immunological memory, characterized by the presence of high titers of specific antibodies against these two drugs of abuse, is also disclosed. Furthermore, the present invention reveals the efficacy of these conjugate formulations for triggering a sustained immunoprotection against morphine and heroin addiction using an intravenous self-administration paradigm of these two opiate substances in the rodent. Finally, a discussion is also made on the potential future use of these immunoconjugates in active vaccination protocols for treating both morphine and heroin addiction in the humans.
Owner:INST NACIONAL DE PSIQUIATRIA RAMON DE LA FUENTE MUNIZ

Variable cross-section standing wave ultrasonic reactor

The invention relates to a variable cross-section standing wave ultrasonic reactor which relates to a device for processing a liquid by utilizing an ultrasonic cavitation effect. The variable cross-section standing wave ultrasonic reactor comprises a box body, at least one ultrasonic transducer (10) and an ultrasonic transducer driving circuit, wherein the box body is used for containing the processed liquid. The cross-sectional area of a standing wave sound field in the box body periodically changes along with the position of a cross section, and the cross section of the sound field is minimum at the position (a sound pressure nodal surface) where a sound pressure amplitude is zero; the cross section of the sound field is maximum at the position (a sound pressure antinodal surface) where the sound pressure amplitude is maximum; and the cross section of the sound field is linearly or nonlinearly transited from the minimum to the maximum between the adjacent sound pressure nodal and antinodal surfaces. The volume of the liquid near the sound pressure antinodal surface is increased and the volume of the liquid near the sound pressure nodal surface is decreased to improve the utilization ratio of the sound field energy of the ultrasonic reactor.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

Variable cross-section standing wave ultrasonic reactor

The invention relates to a variable cross-section standing wave ultrasonic reactor which relates to a device for processing a liquid by utilizing an ultrasonic cavitation effect. The variable cross-section standing wave ultrasonic reactor comprises a box body, at least one ultrasonic transducer (10) and an ultrasonic transducer driving circuit, wherein the box body is used for containing the processed liquid. The cross-sectional area of a standing wave sound field in the box body periodically changes along with the position of a cross section, and the cross section of the sound field is minimum at the position (a sound pressure nodal surface) where a sound pressure amplitude is zero; the cross section of the sound field is maximum at the position (a sound pressure antinodal surface) where the sound pressure amplitude is maximum; and the cross section of the sound field is linearly or nonlinearly transited from the minimum to the maximum between the adjacent sound pressure nodal and antinodal surfaces. The volume of the liquid near the sound pressure antinodal surface is increased and the volume of the liquid near the sound pressure nodal surface is decreased to improve the utilization ratio of the sound field energy of the ultrasonic reactor.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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