Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Freezing-drying powder injectiong contg. Xi-Duo-Fu-Wei

A technology for freeze-dried powder injection and injection, applied in the field of medicine, can solve problems such as single dosage form, and achieve the effects of facilitating storage and transportation, improving stability and ensuring quality

Inactive Publication Date: 2005-01-05
肖广常 +1
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage form of this drug is relatively single at present, which cannot meet the needs of the market.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: cidofovir freeze-dried powder for injection, the components are as follows, all in percentage by weight:

[0019] Cidofovir 78.947%

[0020] Mannitol 21.053%

[0021] The preparation method is as follows:

[0022] Weigh 375g of cidofovir and add 2.4L of water for injection, stir to dissolve, add 100g of mannitol, stir to dissolve, adjust the pH value to 7.4, add water for injection to 3L, and stir well. Add 0.02% charcoal for needles, stir at room temperature for 30 minutes, filter and decarbonize with a titanium filter stick, filter through a double-layer 0.22μm microporous sterile filter, divide the filtrate into 3ml each, and put it in a vacuum freeze dryer , lower the temperature to -40°C, freeze for 5 hours, turn on the vacuum pump, turn off the vacuum freeze dryer, naturally raise the temperature to 20°C, continue vacuuming for 12 hours, control the temperature of the partition to rise to 50°C, continue vacuuming for 9 hours, press the plug out Bo...

Embodiment 2

[0023] Embodiment 2: cidofovir freeze-dried powder for injection, the components are as follows, all in percentage by weight:

[0024] Cidofovir 100%

[0025] The preparation method is as follows:

[0026] Weigh 375 g of cidofovir and add 2.4 L of water for injection, stir to dissolve, adjust the pH value to 7.0, add water for injection to 3 L, and stir well. Add 0.02% charcoal for needles, stir at room temperature for 30 minutes, filter and decarbonize with a titanium filter stick, filter through a double-layer 0.22μm microporous sterilizing filter, divide the filtrate into 3ml per tube, press half plug, and put it in vacuum freezer In the dryer, cool down to -40°C, freeze for 4 hours, turn on the vacuum pump, turn off the vacuum freeze dryer, naturally raise the temperature to 20°C, continue vacuuming for 12 hours, control the temperature of the partition to gradually increase to 50°C, and continue vacuuming for 9 hours , pressing the plug out of the box and rolling the ca...

Embodiment 3

[0027] Embodiment 3: cidofovir freeze-dried powder for injection, the components are as follows, all in percentage by weight:

[0028] Cidofovir 27.273%

[0029] Low Molecular Dextran 72.727%

[0030] The preparation method is as follows:

[0031] Weigh 187.5 g of cidofovir, add 4 L of water for injection, stir to dissolve, adjust the pH value to 7.5, add water for injection to 5 L, and stir well. Add 0.02% charcoal for needles, stir at room temperature for 30 minutes, filter and decarbonize with a titanium filter stick, filter through a double-layer 0.22μm microporous sterilizing filter, divide the filtrate into 5ml per tube, press half the stopper, and put it into vacuum freezing In the dryer, cool down to -45°C, freeze for 6 hours, turn on the vacuum pump, turn off the vacuum freeze dryer, naturally raise the temperature to 20°C, continue vacuuming for 22 hours, control the temperature of the partition to gradually increase to 50°C, and continue vacuuming for 15 hours , ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A Xiduofuwei injection in the form of freeze-dried powder for treating AIDS, cytomegalovirus infection of retina, hepes, simplex virus infection, variola virus infection, etc is prepared from Xiduofuwei, and excipient through proportional dissolving, regulating pH value, filter, quickly freezing, heatingand sublimation drying.

Description

(1) Technical field [0001] The invention relates to cidofovir freeze-dried powder for injection and belongs to the technical field of medicine. (2) Background technology [0002] Cytomegalovirus (CMV) is a pathogen that seriously endangers human health. People of all ages may be infected with CMV, especially newborns, organ transplant recipients, and immunocompromised persons such as HIV-infected persons and AIDS patients. After infection with CMV, it is generally asymptomatic and recessive infection. Once the immune function is impaired, it will lead to serious diseases. The clinical manifestations are fever, lethargy, leukopenia, thrombocytopenia, hepatitis, pneumonia, encephalitis, gastritis and other symptoms of systemic infection. ; 45% of AIDS patients develop acute retinitis with a high rate of blindness. The drugs used to treat CMV infection are ganciclovir and foscarnet. Ganciclovir is currently the drug of choice for the treatment of CMV infection. Due to drug re...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/19A61K31/7052A61P31/12A61P31/22
Inventor 肖广常张颖
Owner 肖广常
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com