Zaltoprofen sustained-release preparation and preparation thereof

A slow-release preparation and slow-release technology, applied in anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc.

Inactive Publication Date: 2008-11-05
SICHUAN DIHON MEDICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no literature reports and varieties of its sustained-release preparations on the market at home and abroad

Method used

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  • Zaltoprofen sustained-release preparation and preparation thereof
  • Zaltoprofen sustained-release preparation and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of Zaltoprofen Sustained Release Tablet 1

[0027] Take Zaltobuprofen 120g and HPMC (K4M) 10g, pulverize them respectively, pass through a No. 9 sieve, put them into a mixing agitator, mix them evenly, use an appropriate amount of 5% PVPK30 ethanol as a binder, and mix them evenly with the above mixed powder Prepare soft materials, pass through a No. 2 sieve to make wet granules, and dry the obtained wet granules. The dried granules are mixed with an appropriate amount of magnesium stearate and micropowder silica gel, and compressed into tablets, 1000 tablets in total.

Embodiment 2

[0028] Example 2 Preparation of Zaltoprofen Sustained Release Tablet 2

[0029] Get Zaltobuprofen 120g, HPMC (K4M) 20g, HPMC (K15M) 20g, pulverize respectively, cross No. 9 sieves, put into mixing agitator, mix uniformly, be binding agent with appropriate amount of 5% PVPK30 ethanol liquid, Mix with the above mixed powder evenly to prepare a soft material, pass through a No. 2 sieve to make wet granules, and dry the obtained wet granules. The dried granules are mixed with an appropriate amount of magnesium stearate and micropowder silica gel, and compressed into tablets, 1000 tablets in total.

Embodiment 3

[0030] Example 3 Preparation of Zaltoprofen Sustained Release Tablet 3

[0031] Get Zaltobuprofen 80g, HPMC (K4M) 20g, HPMC (K100LV) 100g, pulverize respectively, cross No. 9 sieves, put into mixing agitator, mix uniformly, be binding agent with appropriate amount of 5% PVPK30 ethanol liquid, Mix with the above mixed powder evenly to prepare a soft material, pass through a No. 2 sieve to make wet granules, and dry the obtained wet granules. The dried granules are mixed with an appropriate amount of magnesium stearate and micropowder silica gel, and compressed into tablets, 1000 tablets in total.

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PUM

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Abstract

The invention discloses a new formulation of a new non-steroidal anti-inflammatory drug zaltoprofen-a sustained-release preparation of the zaltoprofen and a preparation method thereof; each tablet/each granule of the zaltoprofen sustained-release preparation contains 80 to 240mg of the zaltoprofen and 10 to 120mg of excipients which play the sustained-release function; the sustained-release preparation is conductive to the long-term maintenance of the effective plasma-drug concentration and can improve the efficacy, reduce the side effects, reduce the times of being taken and facilitate the taking and the carry.

Description

Technical field: [0001] The invention relates to a zaltobuprofen anti-inflammatory and analgesic agent for treating chronic rheumatoid arthritis, deformed joint pain, low back pain, frozen shoulder, neck, shoulder and wrist syndrome, and postoperative, traumatic and tooth extraction. Release formulations and methods for their preparation. Background technique: [0002] Zaltoprofen is a new generation of non-specific COX inhibitors. Compared with traditional anti-inflammatory drugs, it has stronger analgesic effects and acute inflammation effects, and significantly reduces toxic and side effects. Taking Zaltoprofen and ibuprofen respectively After that, the incidence of adverse reactions of the digestive system (such as gastric discomfort, stomach pain, belching, diarrhea, etc.) was 3.48% and 15%, respectively, and major adverse reactions (such as acute renal insufficiency, liver dysfunction, peptic ulcer, leukocyte reduction, palpitations, etc.) were <0.1%, <1%. Ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/192A61K47/38A61K47/34A61K47/36A61K9/20A61K9/48A61P19/02A61P29/00A61K47/10A61K47/32
Inventor 陈蜀邓兰黄衡
Owner SICHUAN DIHON MEDICAL DEV
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