Di-demethoxycurcumin precursor liposome and preparation method thereof

A technology of double demethoxy curcumin and double demethoxy curcumin, applied in the fields of biomedicine and targeted preparations, can solve the problems of leakage, fusion, and no disclosure of in vivo data of solid dispersion preparations, etc.
CN101569607AInactive Publication Date: 2009-11-04CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2009-11-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a precursor liposome containing di-demethoxycurcumin and a preparation method capable of industrial application. The weight ratio of the di-demethoxycurcumin to phospholipids together with phospholipid derivatives is 1:5-65, 3 to 20 portions of cholesterol together with derivatives thereof and 0.5 to 5 portions of surfactant are prepared into a freeze-dried powder injection according to the portion ratio of the phospholipids to freeze-drying protective agents being 1:0.25-4. The invention relates to a novel technique and a device for preparing a precursor liposome by an efficient jetting-mixing method, has the advantages of good process reproducibility, controllable technical parameters and the like, and can provide a unilocular liposome with fat-soluble medicaments which are stably wrapped in a phospholipid bilayer. The liposome has the average particle size of between 80 and 300 nm, is narrow in the distribution range of particle size, has entrapment rate of more than 85 percent, is low in leakage rate, and is significantly improved in the stability of preparation storage process. The in vivo circulation time of the novel preparation is obviously prolonged during intravenous injection administration, and the AUC of the novel preparation is 2.67 times that of the common injection.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and targeted preparations, relates to a proliposome of bisdemethoxycurcumin and a preparation method thereof, and provides a device and new technology for producing proliposomes by a high-efficiency jet mixing method Specifically, it is a preparation method for bisdemethoxycurcumin proliposome freeze-dried powder injection for intravenous injection. technical background

[0002] Curcuminoids (curcuminoids) are the main active ingredients of the traditional Chinese medicine turmeric. The three monomers are curcumin (curcumin 1), demethoxycurcumin (curcumin 2) and bisdemethoxycurcumin. (bisdemethoxycurcumin, curcumin 3). Studies have shown that curcuminoids have various pharmacological activities such as anti-cancer, anti-inflammation, anti-oxidation and anti-virus, and have potential advantages in cancer treatment [Chen Minjuan et al. Research progress and application prospects of curcumin. 2003, 15 (1)...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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