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Clopidogrel hydrogen sulfate tablets and production method thereof

A technology of clopidogrel bisulfate tablets and clopidogrel bisulfate, which is applied in pill delivery, blood diseases, extracellular fluid diseases, etc., can solve the problems of high cost of excipients, high requirements of tablet presses, etc., and achieve good fluidity , Improve stability, and good process reproducibility

Inactive Publication Date: 2013-03-27
SHANGHAI MODERN HASEN SHANGQIU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technology reported by CN101601660 is to directly compress the main drug and the auxiliary materials that can be directly compressed into tablets after mixing.

Method used

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  • Clopidogrel hydrogen sulfate tablets and production method thereof
  • Clopidogrel hydrogen sulfate tablets and production method thereof
  • Clopidogrel hydrogen sulfate tablets and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] The present invention will be further illustrated by the following examples, but the protection scope of the present invention is not limited thereto.

[0020]

[0021] The production method of the clopidogrel hydrogen sulfate tablet described in the embodiment includes the following steps: 1) firstly passing the clopidogrel hydrogen sulfate and hydroxypropyl β-cyclodextrin through a 100-mesh sieve, mixing and grinding for 6 hours, and then Pass through a 200-mesh sieve; 2) Spray 70% ethanol under stirring, pass through a 16-mesh sieve to granulate, dry (dry at 35°C for 5 hours), pass through a 14-mesh sieve to granulate, and then add PEG-6000 , After mixing, tableting, coating, aluminum-plastic packaging, labeling, and storage after passing the inspection. 10,000 tablets (75 mg) were prepared from the formulas of Examples 1 and 2, and 30,000 tablets (25 mg) were prepared from the formula of Example 3.

[0022] The clopidogrel bisulfate tablet obtained by the presen...

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Abstract

The invention discloses clopidogrel hydrogen sulfate tablets. Each tablet contains 25-75mg of clopidogrel hydrogen sulfate based on clopidogrel and also comprises a filling agent, an adhesive and a lubricant, wherein the filling agent is beta-cyclodextrin or hydroxypropyl beta-hydroxypropyl; the adhesive is ethanol with volume concentration of 70%; and the lubricant is PEG-6000, PEG-4000 or PEG-2000. Special accessory is adopted in the product; and through the protection effect of the holes of the filling agent on the main drug and the water solubility of the adhesive, the prepared tablet has the characteristics of high dissolution rate, uniform appearance, good stability and the like, and can meet the requirements of industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a clopidogrel hydrogen sulfate tablet and a production method thereof. Background technique [0002] Cardiovascular-related diseases kill more people each year than the four major diseases of cancer, chronic respiratory disease, accidents and diabetes combined. Cardiovascular diseases include stroke, peripheral vascular disease, blood clots, and coronary artery disease, which can cause myocardial infarction, angina, and heart failure. Blood clots can cause heart attacks and strokes, and while blood clots can form for a variety of reasons, a common cause is atherosclerosis. In atherosclerosis, fat and cholesterol build up in the arteries, hardening the walls of the arteries and narrowing the arterial ducts. Some of these arteriosclerotic deposits break away from the vessel wall, causing cardiovascular damage and blood clot formation, and can also ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4365A61P7/02
Inventor 陈洪王英利唐秋玲李新柱江正祥
Owner SHANGHAI MODERN HASEN SHANGQIU PHARMA
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