10 results about "Clopidogrel Bisulfate" patented technology

The invention relates to the field of pharmaceutical preparations, and discloses a clopidogrel hydrogen sulfate tablet and a preparation method thereof, and the clopidogrel hydrogen sulfate tablet comprises the following components: 30-50 parts of clopidogrel hydrogen sulfate; 5-15 parts of a double-layer nano permeable membrane material; 3 to 12 parts of a pH sensitive release material; 5 to 12 parts of a supramolecular self-assembled nanoparticle material; 5 to 15 parts of a solubility regulator; 2-5 parts of an ionic crosslinking regulatory factor; 10 to 25 parts of an excipient; 0.5 to 2 parts of a lubricant; 0.5 to 2 parts of a stabilizer; the double-layer nano permeable membrane material comprises the following components in parts by weight: an inner layer material: 5-15 parts of hydroxypropyl # imgabs0 #-cyclodextrin; 3 to 10 parts of polyvinylpyrrolidone; an outer layer material: 2-8 parts of ethyl cellulose; and 2 to 10 parts of hydroxypropyl methylcellulose. The double-layer nano permeable membrane is combined with the pH-sensitive controlled release system, so that the dissolution rate of the medicine is adjustable, and accurate release in different pH environments is realized. The technical effects of improving the dissolution efficiency, optimizing medicine absorption and reducing individual differences are achieved.

1. The name of the product of this design: packaging box (Alelin Clopidogrel Bisulfate Tablets). 2. Purpose of this design product: used as outer packaging for medicines. 3. The design key points of this appearance design product are: the combination of shape, pattern and color. 4. The picture or photo that best illustrates the key points of the design: main view. 5. The design for which protection is sought includes color.

The present invention relates to a composition for treating and resisting blood coagulation and use thereof, and particularly relates to a pharmaceutical composition containing (7aS, 2'S)-2-oxo-clopidogrel and use thereof. The present invention provides a medicinal specification of a solid preparation which, after oral administration before / after meals for use in healthy adults, can be similar to clopidogrel bisulfate tablets that are 12.5 times larger in specification in terms of Cmax, AUC(0-t), and AUC(0-∞) of a metabolically produced compound A and an active metabolite H4, thereby ensuring the effectiveness and safety of usage of medication.

The present invention relates to a composition for treating and resisting blood coagulation and use thereof, and particularly relates to a pharmaceutical composition containing (7aS, 2'S)-2-oxo-clopidogrel and use thereof. The present invention provides a medicinal specification of a solid preparation which, after oral administration before / after meals for use in healthy adults, can be similar to clopidogrel bisulfate tablets that are 12.5 times larger in specification in terms of Cmax, AUC(0-t), and AUC(0-∞) of a metabolically produced compound A and an active metabolite H4, thereby ensuring the effectiveness and safety of usage of medication.

The invention discloses a clopidogrel and aspirin coated tablet compound preparation, which is a tablet prepared from an inner layer aspirin enteric-coated tablet core and outer layer clopidogrel hydrogen sulfate particles through core-spun pressing, and a coated tablet prepared by coating the tablet with two layers of films, and particularly discloses a preparation method of the clopidogrel and aspirin coated tablet compound preparation. According to the compound preparation prepared by the invention, the stickiness of the medicine is reduced, the fluency of the tabletting process is improved, the problems of precipitation, gun blockage and the like in the coating process are solved by adopting a specific coating material for coating, and meanwhile, the pressure resistance of tablets is improved; and the problems of poor flowability, non-uniform particles and low yield of medicine particles are solved, so that the stability of the compound preparation is improved.

This invention discloses a method for preparing clopidogrel bisulfate tablets and a composition thereof to improve their stability. This invention utilizes a novel porous silica carrier material and a specific process to achieve greater drug loading capacity. By employing a solid dispersion preparation technique, the exposure of clopidogrel bisulfate is reduced. The stability and feasibility of the sample preparation process are improved, and the preparation of a solid dispersion significantly enhances the drug's resistance to damp heat. The samples prepared by this invention are more suitable for production conditions and ensure the stability of the finished product during storage, thus improving the drug's resistance to damp heat.

The invention discloses a clopidogrel hydrogen sulfate tablet with high dissolution rate and stable dissolution rate and a preparation method of the clopidogrel hydrogen sulfate tablet. The method comprises the following steps: carrying out drying treatment on a filling agent and an adhesive, carrying out micro-powder treatment on polyethylene glycol, premixing clopidogrel hydrogen sulfate, other components and treated auxiliary materials, carrying out dry granulation, carrying out tabletting and carrying out coating operation. Through fine particle size control and formula optimization, the method can significantly improve the dissolution rate and stability of the clopidogrel hydrogen sulfate tablet. The preparation method has the advantages of simple operation, strong controllability, good product consistency and the like, and is suitable for large-scale production.

The invention discloses a clopidogrel-containing solid preparation and a preparation method thereof, the clopidogrel-containing solid preparation is prepared by tabletting clopidogrel particles, the clopidogrel-containing solid preparation comprises clopidogrel hydrogen sulfate, a filler, a disintegrating agent, an antioxidant, a lubricant and polyethylene glycol 6000, the particle size of the polyethylene glycol 6000 is 40-80 meshes, the antioxidant is dissolved in a wetting agent and is added in an atomized manner, and the filler, the disintegrating agent, the antioxidant, the lubricant and the polyethylene glycol 6000 are mixed uniformly. The clopidogrel hydrogen sulfate particles which are not sticky and do not generate yellow spots are prepared through wet granulation, and the clopidogrel hydrogen sulfate particles are good in stability and easy to produce on a large scale.

1. The name of the design product: packaging box (clopidogrel bisulfate tablets). 2. The use of the design product: for packaging box. 3. The design points of the design product: in the combination of shape and pattern. 4. The picture or photo that best indicates the design points: front view.

The invention provides a clopidogrel and aspirin composite tablet and a preparation method thereof, and relates to the technical field of medicines. The clopidogrel and aspirin composite tablet has a multi-layer coating structure, and sequentially comprises an aspirin tablet core, a coating layer and a clopidogrel hydrogen sulfate shell layer from inside to outside, the coating layer at least comprises an isolation coating layer and an enteric coating layer, and the isolation coating layer is coated with the enteric coating layer. Preferably, during preparation of the clopidogrel hydrogen sulfate shell layer, volatile water or an alcohol-water solution is used as an adhesive. The clopidogrel and aspirin composite tablet disclosed by the invention is good in dissolution performance and good in stability.