5 results about "Clopidogrel Bisulfate" patented technology

The present invention relates to a composition for treating and resisting blood coagulation and use thereof, and particularly relates to a pharmaceutical composition containing (7aS, 2'S)-2-oxo-clopidogrel and use thereof. The present invention provides a medicinal specification of a solid preparation which, after oral administration before / after meals for use in healthy adults, can be similar to clopidogrel bisulfate tablets that are 12.5 times larger in specification in terms of Cmax, AUC(0-t), and AUC(0-∞) of a metabolically produced compound A and an active metabolite H4, thereby ensuring the effectiveness and safety of usage of medication.

This invention discloses a method for preparing clopidogrel bisulfate tablets and a composition thereof to improve their stability. This invention utilizes a novel porous silica carrier material and a specific process to achieve greater drug loading capacity. By employing a solid dispersion preparation technique, the exposure of clopidogrel bisulfate is reduced. The stability and feasibility of the sample preparation process are improved, and the preparation of a solid dispersion significantly enhances the drug's resistance to damp heat. The samples prepared by this invention are more suitable for production conditions and ensure the stability of the finished product during storage, thus improving the drug's resistance to damp heat.

The invention discloses a clopidogrel hydrogen sulfate tablet with high dissolution rate and stable dissolution rate and a preparation method of the clopidogrel hydrogen sulfate tablet. The method comprises the following steps: carrying out drying treatment on a filling agent and an adhesive, carrying out micro-powder treatment on polyethylene glycol, premixing clopidogrel hydrogen sulfate, other components and treated auxiliary materials, carrying out dry granulation, carrying out tabletting and carrying out coating operation. Through fine particle size control and formula optimization, the method can significantly improve the dissolution rate and stability of the clopidogrel hydrogen sulfate tablet. The preparation method has the advantages of simple operation, strong controllability, good product consistency and the like, and is suitable for large-scale production.

The invention discloses a clopidogrel-containing solid preparation and a preparation method thereof, the clopidogrel-containing solid preparation is prepared by tabletting clopidogrel particles, the clopidogrel-containing solid preparation comprises clopidogrel hydrogen sulfate, a filler, a disintegrating agent, an antioxidant, a lubricant and polyethylene glycol 6000, the particle size of the polyethylene glycol 6000 is 40-80 meshes, the antioxidant is dissolved in a wetting agent and is added in an atomized manner, and the filler, the disintegrating agent, the antioxidant, the lubricant and the polyethylene glycol 6000 are mixed uniformly. The clopidogrel hydrogen sulfate particles which are not sticky and do not generate yellow spots are prepared through wet granulation, and the clopidogrel hydrogen sulfate particles are good in stability and easy to produce on a large scale.

1. The name of the design product: packaging box (clopidogrel bisulfate tablets). 2. The use of the design product: for packaging box. 3. The design points of the design product: in the combination of shape and pattern. 4. The picture or photo that best indicates the design points: front view.