72results about How to "The crystallization process is easy to control" patented technology

The invention relates to a method for improving mechanical properties of an aramid fiber in a supercritical fluid through stretching orientation. A supercritical carbon dioxide fluid is utilized for partially destroying interaction of a PPTA (poly-p-phenylene terephthamide) molecular chain in the aramid fiber under the action of certain tension, and the molecular chain is further oriented, so that the aramid fiber with good properties is obtained. The method for improving the mechanical properties of the aramid fiber in the supercritical fluid through stretching orientation mainly comprises the following steps: ensuring that the aramide fiber maintains certain tension in a closed container, introducing CO2 into the container at a certain temperature, so that the internal space of the closed container is in a supercritical CO2 state, carrying out swelling reaction for a period of time, and slowly releasing pressure, thus the highly stretching-oriented aramid fiber is obtained. The method for improving the mechanical properties of the aramid fiber in the supercritical fluid through stretching orientation guarantees that the aramid fiber is in a stretched state in a reaction process, so that orientation degree and crystallinity of a molecular chain are increased while stretching tension is changed, crystal particles are largened, and crystals are more and more complete.

The invention provides a novel crystal form of cefuroxime sodium and a preparation method of cefuroxime sodium crystal. According to the novel crystal form crystal, the X-ray powder diffracting at the diffraction angles 2theta of 3.5+ / -0.2, 10.6+ / -0.2, 12.7+ / -0.2, 18.6+ / -0.2, 19.5+ / -0.2 and 22.4+ / -0.2 has characteristic peaks. The DSC graph has a characteristic peak at the angle of 235+ / -2 degrees. The method for preparing the novel cefuroxime sodium crystal comprises the following steps: adding 2.5-5g of cefuroxime acid with the purity of 99 percent into 100mL of a solvent for stirring at the temperature of 20-25 DEG C, drilling 0.2-0.4g / mL of sodium lactate-methanol solution for reacting until the pH value of the solution is 6.0-6.5; adding a solventing-out agent for performing solvent-out crystallization; and filtering, washing and drying the crystal mush, thereby obtaining the cefuroxime sodium crystallization product with the crystal form.

The invention discloses a crystallizing method for obtaining I crystal form (+)-(S)-clopidogrel bisulfate. The method disclosed by the invention comprises the following steps: dissolving (+)-(S)-clopidogrel free alkali in an alcohol solvent, and dropwise adding an alcohol solution of concentrated sulfuric acid, thereby obtaining the I crystal form (+)-(S)-clopidogrel bisulfate by controlling the dropwise adding temperature, mixing time and recrystallization temperature.

The invention relates to a large-scale ingot casting method for preparing Ti-6Al-4V titanium alloy, the invention adopts multiple-time vacuum self-consuming smelting method on the basis of routine technique, adopts a 'constant speed' finished product smelting method and adopts smelting speed control parameters to control the technological parameters in the finished product smelting process.The invention is characterized in that the smelting speed control parameter is 20-32Kg / min; the real smelting weight is on-line measured each second or according to a set time and an instant smelting speed is the ratio of the real smelting weight and the measurement time interval; if the smelting speed is higher than a desired value, the smelting current is then reduced; if the smelting speed is lower than the desired value, the smelting current is then increased. By using the control method, temperature field can be controlled effectively, distribution coefficient can be optimized, stabilization of the from and depth of the melting bath can be assured, which make the ingot casting sequence and solidification process stable and controllable, and homogeneity of components of large-scale ingot casting can also be assured.

The invention discloses an olaparib and malonic acid eutectic crystal and a preparation method thereof. In the eutectic crystal, the molar ratio of olaparib to malonic acid is 1: 1; the eutectic X-raypowder diffraction pattern has characteristic peaks when the 2theta value is at the positions of 9.8 + / -0.2 degrees, 12.4 + / -0.2 degrees, 12.6 + / -0.2 degrees, 13.4 + / -0.2 degrees, 16.2 + / -0.2 degrees, 17.5 + / -0.2 degrees, 18.7 + / -0.2 degrees and 21.0 + / -0.2 degrees. The eutectic preparation method is simple in process, easy to control the crystallization process, good in reproducibility and suitable for industrial production. Compared with olaparib free alkali, the eutectic crystal has higher apparent solubility, and is beneficial to improving the oral absorption efficiency of olaparib.

A cooling unit for a modification process of long glass fiber reinforced plastic comprises a plurality of cooling water tanks arranged in parallel. Each cooling water tank is composed of a small tank and a large tank arranged below the small tank; the temperature of water in the large and small tanks decreases gradually along a moving direction of strips; grilles are disposed at two ends of the top of the small tank and are composed of a plurality of circular columns; a gap between every circular columns is used as a passage allowing passage of the strips; circulating pumps are disposed in the large and small tanks and provide water to the small tank through a pipe, the water in the small tank can flow back into the large tank through the grilles, and the water level of the small tank is lower than the horizontal plane which the strips pass by. The cooling unit has the advantages that the multiple cooling tanks of different temperatures are used to gradually cool the strips, defective rate of the strips can be evidently decreased, lean production is achieved, and waste of cooling water is avoided.

The invention discloses an olaparib-urea eutectic crystal and a preparation method thereof. In the eutectic crystal, a molar ratio of olaparib to urea is 1: 2; in an X-ray powder diffraction pattern of the eutectic crystal, characteristic peaks occur when the value of 2theta is 6.4 + / - 0.2 degrees, 14.3 + / - 0.2 degrees, 15.0 + / - 0.2 degrees, 18.6 + / - 0.2 degrees, 19.2 + / - 0.2 degrees, 24.3 + / -0.2degrees and 24.8 + / -0.2 degrees. The preparation method of the eutectic crystal provided by the invention is simple in process, a crystallization process is easy to control, good in reproducibility and suitable for industrial production. Compared with olaparib free alkali, the eutectic crystal has higher apparent solubility and is beneficial to improving the oral absorption efficiency of olaparib.

The present invention designs a method for regulating the growth of spherical rubrene crystals by the co-solvent of the polymer induction layer, that is, the method of regulating the orderly growth of rubrene molecules into spherical crystals through the induction layer of polystyrene (PS) under the co-solvent of chloroform . By spin-coating the polymer-induced layer (2) of chloroform solvent, a layer of substrate modification layer film (3) with uniform and directional arrangement is formed, and then the rubrene semiconductor layer (4) of chloroform solvent is drip-coated, using a co-solvent The microscopic arrangement of polymer molecules induces the growth of highly ordered arrangement of rubrene crystals, forming dense spherical rubrene crystals (9). The invention has simple operation and low cost, can obtain large-area, continuous and uniform rubrene spherical crystals, and lays a foundation for the growth of organic semiconductor thin film crystals with high mobility.

The invention discloses a method for extracting naphthalin from heavy C10 aromatic solvent oil by an integral device. The integral device comprises a multistage axial stirring crystallizer device, a filter device and a collecting device which are sequentially connected from top to bottom. The method comprises the following steps of adding the raw material of heavy C10 aromatic solvent oil from a feeding opening; controlling the feeding speed and the rotating speed of the stirring shaft; controlling the crystallization and the filtering to be at the same temperature through constant temperaturemedia; performing vacuum pumping on the filter device so that the filter device is in a vacuum state; downwards flowing the raw materials into the filter device from the multistage axial stirring crystallizer device; performing vacuum filtering in the filter device; finally, collecting filter liquid through the collecting device; collecting filter cake through the filter device, wherein the filter cake is the extracted naphthalin. The method has the advantages that the process is simple; the continuous operation can be realized; the used device is integral; the crystallization and the filtering can be conveniently controlled to be at the same temperature; after the condition of optimization separation, the naphthalin content in the light C10 aromatic solvent oil is lower than 3 percent; the content and the yield of naphthalin are as high as 99.54 percent and 97.17 percent or higher.

The invention discloses a penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal and a preparation method thereof. In the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal, the molar ratio of penciclovir to 3,5-dihydroxybenzoic acid is 1:1. The preparation method of the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal is simple in process, the crystallization process is easyto control, the reproducibility is good, and the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal is suitable for industrial production. Compared with penciclovir, the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal has the advantages that the dissolution rate is higher, the apparent solubility is higher, the bioavailability of the penciclovir is favorably improved, and a material basis is provided for successfully developing oral preparations and liquid preparations of penciclovir.

The invention discloses a pearl paste-like sodium fatty acylglutamate composition, which is prepared from the following components in mass percentage: sodium fatty acylglutamate 6-40%, disodium fatty acylglutamate 10‑40%, fatty acylglutamic acid 3‑20%, polyol 5‑30%, salt 0‑5%, deionized water 10‑55%, preservative 0.1‑1%. The invention also provides a facial cleanser. The composition of the present invention can effectively avoid the problems of uneven texture and large dust existing in the prior art during production, and its formula construction is relatively simple, the raw materials are convenient to obtain, the production is convenient, there is no dust pollution, and it is easy to thicken. The advantage of crystallization is easy to control.

The invention discloses a metformin-tolbutamide new salt type and a preparation method and medical application thereof. The preparation method comprises the following steps: dissolving metformin and tolbutamide in an appropriate solvent, reacting, crystallizing, filtering and drying. The preparation method has simple operation, good reproducibility and easy control. The hygroscopicity and stability of the metformin-tolbutamide new salt type are greatly improved compared with that of a metformin single product, the solubility of the metformin-tolbutamide new salt type is greatly improved compared with that of a tolbutamide single product, the preparation method is simple, the crystallization process is easy to control, and the metformin-tolbutamide new salt type has good repeatability.