1results about How to "The crystallization process is easy to control" patented technology

The present application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a crystal form of lamivudine salt of m-hydroxybenzoic acid and a preparation method thereof. The crystal form has an X-ray diffraction spectrum expressed by 2theta using Cu-Kalpha radiation, and has characteristic peaks at least at 9.26+ / -0.2, 12.56+ / -0.2, 13.05+ / -0.2, 14.59+ / -0.2, 17.45+ / -0.2, 20.30+ / -0.2, 21.76+ / -0.2, 23.37+ / -0.2, 25.05+ / -0.2 and 27.58+ / -0.2; the crystal form is composed of a molecule of lamivudine, a molecule of m-hydroxybenzoic acid and a molecule of n-butanol as a basic unit; meanwhile, the crystal form has good solubility, provides ideal raw material for preparing parenteral dosage forms which are convenient to administer and have rapid effect, and thus better meets the requirements of clinical application.