Co-crystal of abiraterone acetate and trans-aconitic acid, and preparation method, pharmaceutical composition and application thereof
A technology of abiraterone acetate and trans-aconitic acid is applied in the directions of drug combination, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., to achieve high bioavailability, obvious improvement, and improved solubility Effect
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Embodiment 1
[0053] Abiraterone acetate 0.1mmol and trans-aconitic acid 0.05mmol are added in 4 milliliters of ethanol according to stoichiometric ratio 2:1, after dissolving completely, slowly volatilize at room temperature again, obtain abiraterone acetate and trans-aconitic acid Co-crystal of head acid.
Embodiment 2
[0055] Add 0.1mmol of abiraterone acetate and 0.05mmol of trans aconitic acid into 4 milliliters of methanol according to the stoichiometric ratio of 2:1, after completely dissolving, volatilize slowly at 50 degrees Celsius to obtain abiraterone acetate and trans aconitic acid Co-crystal of aconitic acid.
Embodiment 3
[0057] Abiraterone acetate 0.1mmol and trans-aconitic acid 0.05mmol are added in 4 milliliters of acetone according to stoichiometric ratio 2:1, after dissolving completely, slowly volatilize under the condition of 50 degrees Celsius again, obtain abiraterone acetate and trans-aconitic acid Co-crystal of aconitic acid.
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