Eutectic crystal of lenvatinib and benzoic acid, and preparation method thereof
A technology of lenvatinib and benzoic acid, applied in the field of medicinal chemistry, can solve the problems of limited clinical application, poor water solubility of lenvatinib mesylate, high cost, etc.
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[0039] Example 1
[0040] Weigh 600 mg of lenvatinib and 172 mg of benzoic acid, add 4 mL of acetonitrile and 4 mL of water to obtain a suspension, place the suspension at room temperature and stir for 1 h, filter, and dry the white solid obtained at 50°C to obtain lenvatinib and The yield of the solid sample of the benzoic acid co-crystal was 88.2%.
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[0041] Example 2
[0042] Weigh 60 mg of lenvatinib and 17.2 mg of benzoic acid, and add 1 mL of anisole to obtain a suspension. The suspension is stirred at room temperature for 12 hours, filtered, and the white solid obtained is dried at 50°C to obtain levatinib Solid sample co-crystal with benzoic acid.
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[0043] Example 3
[0044] Weigh 60 mg of lenvatinib and 17.2 mg of benzoic acid, add 10 μL of isopropanol, and grind for 30 minutes at a frequency of 20 Hz. The white solid obtained is dried at 40° C. to obtain a solid sample of co-crystal of lenvatinib and benzoic acid.
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