2results about How to "Improve apparent solubility" patented technology

This invention relates to the field of biomedical materials technology. It discloses a metal-organic hydrogel-mediated soluble microneedle patch, its preparation method, and its applications. The microneedle patch comprises a matrix and needles, wherein the matrix and needles contain a metal-organic hydrogel, polydimethylsiloxane, and a poorly soluble target drug. This application innovatively applies a metal-organic hydrogel to the preparation of a soluble microneedle patch, constructing an amphiphilic matrix with polydimethylsiloxane. This enables the preparation of soluble microneedle formulations containing uniformly distributed poorly soluble drugs, expanding the application scenarios for poorly soluble drugs and improving resource utilization. It has significant value in the formulation preparation of poorly soluble drugs.

This invention relates to a butylphthalide cationic nanoemulsion, its preparation method, and its application, belonging to the field of pharmaceutical technology. The butylphthalide cationic nanoemulsion comprises an oil phase, an aqueous phase, butylphthalide, an emulsifier, a co-emulsifier, an osmotic pressure regulator, and a cationic surfactant. The butylphthalide content in the nanoemulsion is 0.30%–2.50% by mass. The average particle size of the butylphthalide cationic nanoemulsion is 80–200 nm, the polydispersity index is 0.070–0.200, and the zeta potential is 20–30 mV. This invention solves the problems of poor water solubility and low stability of butylphthalide by preparing it into a nanoemulsion formulation; furthermore, by administering it via nasal administration, it meets the need for rapid neuroprotection in ischemic stroke.