51results about How to "Improve apparent solubility" patented technology

The invention belongs to the technical field of high polymer chemistry, biomedical materials and pharmacy, and particularly discloses ciclosporin A eye drops and a preparation method thereof. Every 1,000 mL of the eye drops are prepared from the following substances: ciclosporin A 30-630 mg, a polymer-grafted copolymer 1-10 g, and the balance of injection water, wherein the polymer-grafted copolymer is chitosan-g-cyclodextrin. The preparation method comprises the following steps: firstly, weighing the chitosan-g-cyclodextrin as the polymer-grafted copolymer, adding and dissolving equivalent injection water in the chitosan-g-cyclodextrin, and stirring and dissolving until a solution is transparent; secondly, adding an ethanol solution of the ciclosporin A in the solution, stirring at the temperature of 0-4 DEG C until a system becomes completely clear; thirdly, removing ethanol under reduced pressure at the temperature of 0-4 DEG C and washing; and finally, adding the injection water and determining the volume, and sterilizing to obtain the final product. The eye drops have the advantages that irritation of the medicine is reduced, the residence time of the medicine on an ocular surface is prolonged, the corneal permeability of the medicine is improved, and the treatment effect of the medicine is also improved.

The invention relates to a usnic acid nano-suspension and its preparation method and application. Specifically, the present invention relates to the usnic acid nanosuspension and its preparation method, as well as its use as a preparation intermediate to prepare other pharmaceutical preparations, and also relates to the pharmaceutical composition prepared from the usnic acid nanosuspension.

The invention discloses a method for preparing low-density maltodextrin, which comprises the step of taking corn or rice or tubers as a raw material, and steps of size mixing, spraying and liquefying, micropore refining and spray drying to obtain the product. The method improves and optimizes the prior producing technology of the maltodextrin, namely preparing starch to have low density suitable for liquefying enzyme and have a pH value of between 3 and 5, spraying and liquefying the starch twice by high temperature, and refining the starch by a micropore. The density of the product prepared by the spray drying reaches less than 0.10 g / cm<3>; and the product is in shape of hollow ball, and has the advantages of large apparent solubility, low sweetness, low hydroscopic property, no easy caking, and the like.

The invention discloses a compounded ophthalmic preparation which comprises a solid component A and a component B, wherein the component B is used as a buffer isotonic solution; the component A comprises a chondroitin sulfate cross-linking modified carboxylated beta-cyclodextrin carrier as well as components, namely sodium hyaluronate, trehalose, glycine betaine and alanyl glutamine matrix which are carried by the carrier; and the component B as the buffer isotonic solution comprises povidone, taurine, glycerinum and / or a sodium chloride isotonic agent, an antibacterial agent, a pH value adjusting agent and injection water. The preparation disclosed by the invention is used for alleviating asthenopia and relieving xerophthalmia symptoms, has very high stability and can be preserved for a long time without a preservative.

The invention discloses a co-crystal of lenvatinib and p-hydroxybenzoic acid and a preparation method thereof. This co-crystal contains lenvatinib and p-hydroxybenzoic acid in a molar ratio of 1:1; the X-ray powder diffraction pattern of the co-crystal measured with Cu Kα rays is 6.3±0.2°, 10.6±0.2 °, 12.4±0.2°, 14.6±0.2°, 17.5±0.2°, 18.4±0.2° have characteristic peaks. The present invention converts lenvatinib into a brand-new co-crystal of lenvatinib and p-hydroxybenzoic acid for the first time, and the co-crystal of lenvatinib and p-hydroxybenzoic acid has a faster dissolution rate and a larger apparent Solubility. The preparation method of the co-crystal of lenvatinib and p-hydroxybenzoic acid has simple process, easy control of the crystallization process, good reproducibility, is suitable for industrial production, and has broad application prospects.

The invention discloses a penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal and a preparation method thereof. In the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal, the molar ratio of penciclovir to 3,5-dihydroxybenzoic acid is 1:1. The preparation method of the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal is simple in process, the crystallization process is easyto control, the reproducibility is good, and the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal is suitable for industrial production. Compared with penciclovir, the penciclovir and 3,5-dihydroxybenzoic acid eutectic crystal has the advantages that the dissolution rate is higher, the apparent solubility is higher, the bioavailability of the penciclovir is favorably improved, and a material basis is provided for successfully developing oral preparations and liquid preparations of penciclovir.

The invention provides a method for chemical elution-plant combined repairing polychlorinated biphenyl contaminated soil, which belongs to the field of contaminated soil restoration, and comprises the following steps: taking the contaminated soil to be repaired, grinding and pulverizing, passing through a 60-mesh sieve, and adjusting the sieve The water content of the final soil should be adjusted to keep the soil water content at 40% to 60% of its field water capacity, and it will be used for later use; the alfalfa seeds that have been treated with germination will be evenly spread in the spare soil for cultivation, and the alfalfa plants will grow for two weeks. Thinning it afterward, the alfalfa plant cultivation period is 90 days; Begin to spray eluent in soil from thinning, spray once every 5 days to 8 days, thereby repair polychlorinated biphenyls in soil, and prior art Compared with the present invention, the operation is simple and the treatment effect is good, and in-situ restoration can be realized. The restoration process has little impact on the original environment, and a wide range of soil types are used. When used in actual environmental restoration, the risk of secondary pollution is greatly reduced, which is beneficial to subsequent soil restoration. Recycling.

The invention belongs to the technical fields of high polymer chemistry, biomedical materials and pharmacy and particularly discloses eye drops with a polymer-grafted copolymer as a carrier and a preparation method of the eye drops. Each 1000mL of the eye drops are prepared from the following materials: 2g to 30g of eye drops medicament, 10g to 200g of polymer-grafted copolymer, 0.5g to 20g of hydroxysuccinic acid, and the balance of water for injection, wherein the polymer-grafted copolymer is chitosan-g-cyclodextrin. The preparation method comprises the following steps: firstly, weighing the chitosan-g-cyclodextrin serving as the polymer-grafted copolymer, adding the water with dissolved equivalent amount for injection into the chitosan-g-cyclodextrin, and stirring and dissolving until a transparent solution is obtained; secondly, adding the eye drops medicament and the hydroxysuccinic acid into the solution, and stirring to be completely dissolved; finally, adding the water for injection, metering the volume, and sterilizing to obtain the eye drops. After the eye drops disclosed by the invention is applied to an ocular surface, the eye drops have the following predominant advantages that the irritation of the medicament is reduced, the detention time of the medicament on the ocular surface is prolonged, the corneal permeability of the medicament is improved, and the treatment effect of the medicament is improved.