3results about How to "Improve apparent solubility" patented technology

This invention relates to the field of biomedical materials technology. It discloses a metal-organic hydrogel-mediated soluble microneedle patch, its preparation method, and its applications. The microneedle patch comprises a matrix and needles, wherein the matrix and needles contain a metal-organic hydrogel, polydimethylsiloxane, and a poorly soluble target drug. This application innovatively applies a metal-organic hydrogel to the preparation of a soluble microneedle patch, constructing an amphiphilic matrix with polydimethylsiloxane. This enables the preparation of soluble microneedle formulations containing uniformly distributed poorly soluble drugs, expanding the application scenarios for poorly soluble drugs and improving resource utilization. It has significant value in the formulation preparation of poorly soluble drugs.

This invention relates to a butylphthalide cationic nanoemulsion, its preparation method, and its application, belonging to the field of pharmaceutical technology. The butylphthalide cationic nanoemulsion comprises an oil phase, an aqueous phase, butylphthalide, an emulsifier, a co-emulsifier, an osmotic pressure regulator, and a cationic surfactant. The butylphthalide content in the nanoemulsion is 0.30%–2.50% by mass. The average particle size of the butylphthalide cationic nanoemulsion is 80–200 nm, the polydispersity index is 0.070–0.200, and the zeta potential is 20–30 mV. This invention solves the problems of poor water solubility and low stability of butylphthalide by preparing it into a nanoemulsion formulation; furthermore, by administering it via nasal administration, it meets the need for rapid neuroprotection in ischemic stroke.

The invention belongs to the technical field of aquaculture, and discloses compound parasite-expelling granules for aquaculture and a preparation method and application thereof, and the compound parasite-expelling granules are prepared from methylamino abamectin benzoate, novaluron, a surfactant, an antioxidant, a disintegrating agent and a filler. According to the invention, methylamino abamectin benzoate and chlorfenuron are selected as active components to repel and kill crustacean parasites, and at present, an oral anthelmintic compounded by the two components as active components and used for aquaculture does not exist. The methylamino abamectin benzoate death by paralyzing insect bodies, has slow metabolism in vivo, has high toxicity to aquatic animals, and is not easy to use in a large amount or for a long time; the main action mechanism of the novaluron is to inhibit the synthesis of chitin, and the novaluron takes effect slowly, but is relatively safe to aquatic animals, and has a special effect on resistant parasites such as organic phosphorus, pyrethroid and the like. Clinical verifications show that the two components have a synergistic effect, and the killing effect on crustacean parasites is far better than that of an existing aquatic insecticide.