The invention relates to a production process of a hot-rolled composite blank. The production process comprises the following steps of: (1), cleaning base metal plates and clad metal plates, and cleaning the surface of a to-be-composited surface by use of a milling machine so that the surface is clean; (2), putting a high-temperature antisticking agent between the two clad metal plates, and putting the two superposed clad metal pates between the two base metal plates; (3), putting base plate metal strips at the parts, which are adjacent to the edges, of a gap between the two base metal plates, and performing spot welding on the base metal plates and the base plate metal strips so that the metal plates are fixed to form a blank; (4), sealing the peripheral edges of the blank by virtue of welding the blank via vacuum electron beam welding so as to form a dual-metal composite steel plate blank; and (5) heating the dual-metal composite steel plate blank in a heating furnace, discharging the blank out of the heating furnace, rolling the blank by virtue of a high-power medium and heavy plate mill, straightening after rolling, and trimming to obtain the hot-rolled composite blank. The production process is simple, good in combination quality, high in efficiency, relatively low in production cost, short in period, easy for production organization and low in loss.