The invention discloses a railway vehicle chassis with a large-section draft, bolster and buffer structure. The railway vehicle chassis comprises a draft bolster buffer, a front end beam, a left side beam, a right side beam and a floor, the draft bolster buffer comprises a small draft sill, a buffer beam, a large draft sill and a bolster, the floor comprises an in-pillow floor, an out-pillow left floor, an out-pillow right floor, an end floor, a middle cover plate and a floor transition sectional material, the front end beam is connected with the left side beam, the right side beam and the small draft sill, the end floor is erected on the left side beam and the right side beam, the middle cover plate is erected on the large draft sill, the out-pillow left floor is erected on the large draft sill and the left side beam, the out-pillow right floor is erected on the large draft sill and the right side beam, the floor transition sectional material is erected on the bolster, the in-pillow floor is connected to the floor transition sectional material in an inserted mode, the in-pillow floor is erected on the left side beam and the right side beam, and the upper surfaces of the buffer beam, the large draft sill and the bolster are flush with the upper surface of the floor. The structural strength is improved.