25results about "Ether preparation" patented technology

The application discloses a preparation method of a key intermediate of dapagliflozin, and belongs to the technical field of preparation of medical intermediates. The preparation method of the key intermediate of dapagliflozin comprises the following steps: 1, 1-ethoxy-4-methylbenzene is prepared by using p-cresol, sodium hydroxide and diethyl sulfate; 2, (4-ethoxybenzyl) phenyl sulfide is prepared by using 1-ethoxy-4-methylbenzene, thiophenol, a palladium catalyst, an alkali and an oxidant; 3, 1-benzyl-4-ethoxybenzene is prepared by using (4-ethoxybenzyl) phenyl sulfide under a hydrogen atmosphere; 4, 4-ethoxy-2'-chlorobenzhydrol is prepared by carrying out chlorination reaction on 1-benzyl-4-ethoxybenzene; and 5, 5-bromo-2-chloro-4'-ethoxybenzhydrol is prepared by carrying out bromination reaction on 4-ethoxy-2'-chlorobenzhydrol. The yield and purity of 5-bromo-2-chloro-4'-ethoxybenzhydrol prepared by the method are higher, the process is safer, and the production cost is reduced.

The application discloses a kind of lignin-based aryl formate and diaryl ether compound and synthesis method thereof, belong to the technical field of organic compound synthesis.The method uses lignin β-O-4 model compound as reaction raw material, under the condition of oxidant and alkali, after heating reaction, then join diaryl iodonium under air atmosphere and stir, obtain aryl formate and diaryl ether compound.The synthesis method of the application has the advantages of simple operation, mild reaction condition and high product selectivity, provides a new way for the preparation of aryl formate and diaryl ether compound.

This invention discloses a method for the deamination functionalization of aliphatic nitrosamines, comprising: reacting an aliphatic nitrosamine as shown in formula (II) with a nucleophile in the presence of an acid and a solvent to generate a deamination functionalized product as shown in formula (III); wherein, R 1 R 2 R 3 Each group is independently selected from hydrogen, hydroxyl, alkyl, alkoxy, alkanoyl, alkoxycarbonyl, alkylsulfinyl, alkylsulfonyl, aryl, heteroaryl, phenylalkyl, or R 1 R 2 R 3 Two or three of the functional groups form a non-aromatic ring, cage-like compound; FG is a functional group in which a nucleophile participates in the reaction. The method of this invention has the advantages of inexpensive and readily available raw materials, simple reaction conditions, and wide substrate applicability.

The present invention provides a method for producing a fluorine-containing compound by introducing a fluorine atom into a wide variety of oxygen-containing compounds having a ketone group, an aldehyde group, a hydroxy group, or the like using SF5− stabilized by forming a salt with a glyme-coordinated alkali metal ion as a deoxofluorinating agent under relatively mild conditions.The present invention pertains to a method for producing a fluorine-containing compound, the method in which a fluorine-containing compound is produced by the deoxofluorination of an oxygen-containing compound having an aldehyde group, a ketone group, a carboxy group, or a hydroxy group in one or more solvents selected from the group consisting of DMPU, G4, DMA, HMPA, and MeCN using a deoxofluorinating agent represented by a general formula (E1) [in the formula, M represents Cs+, K+, or Rb+; G4 represents a tetraethylene glycol dimethyl ether; and n represents an integer of 1 to 4].

This fullerene derivative has a structure represented by formula (1) or formula (2) (wherein Ar represents a substituted or unsubstituted aromatic ring, * represents a carbon atom at a linkage point with respect to a fullerene core, X represents O, S, Se, or Te, and R represents an organic group).

This invention discloses a method for the kinetic resolution of oxaspirone via organocatalytic hydrogenolysis. Using chiral phosphate CPA as a catalyst, Hantzsch ester as a hydrogen source, and racemic oxaspirone 2,4-dien-6-one rac-1 as a substrate, a series of axially chiral biaryl phenolic compounds 2 are synthesized via asymmetric hydrogenolysis, and the central chiral oxaspirone 1 is recovered. This invention offers advantages such as simple and practical operation, readily available raw materials, high resolution coefficient, and good enantioselectivity. Some of the axially chiral biaryl products have structures similar to axially chiral cannabinol, possessing potential medicinal value.

A method for producing ethers, comprising treating (a) an ester with (b) hydrogen in the presence of (c) a heterogeneous catalyst to reduce the ester by hydrogenation to form an ether product.

The embodiment of the present application provides a high-boiling hydrogen fluoride alkene ether compound and a preparation method and application thereof, relates to the field of fluorine chemical industry and heat management technology. The hydrogen fluoride alkene ether compound provided by the embodiment of the present application has a structure shown in formula I. The hydrogen fluoride alkene ether compound provided by the embodiment of the present application has excellent environmental protection (ODP value is 0, and GWP value is less than 100) and high boiling point (> 150 DEG C), thereby having a wide adaptive temperature range. Moreover, the hydrogen fluoride alkene ether compound has excellent material compatibility, has no corrosiveness to various metals, high polymer materials and glass ceramic materials; has low low-temperature viscosity; has excellent insulation performance and good high-temperature resistance. The hydrogen fluoride alkene ether compound is used as a temperature control working medium, has high efficient temperature control stability advantages, and can achieve the purpose of energy saving and consumption reduction. The embodiment of the present application provides a preparation method of the hydrogen fluoride alkene ether compound, raw materials are easy to obtain, the process is simple, the yield is high, and excellent cost advantages are achieved.

Provided is a method for producing a fluorinated organic compound by fluorinating an organic compound in the presence of a fluorinating composition comprising IF5, iodine, and an amine, the composition comprising the iodine in an amount of 0.12 mol or less per mole of the IF5. This production method can synthesize a fluorinated organic compound with high efficiency.

A process for the preparation of chloromethyl ethyl ether is disclosed. The process comprises reacting paraformaldehyde with ethanol and thionyl chloride. The present invention further discloses a process for the preparation of substantially pure acetochlor comprising the step of treating a crude mixture of acetochlor and 2-chloro-N-(2-ethyl-6-methylphenyl)acetamide with chloromethyl ethyl ether in the presence of a base and a solvent at a temperature of about 0°C to about 40°C, thereby making the process simple, economical and industrially viable and thereby providing acetochlor with reduced content of 2-chloro-N-(2-ethyl-6-methylphenyl)acetamide.

The application relates to the technical field of catalysts, in particular to a preparation method of alpha-MoC and products and applications thereof, at least comprising the following steps: S1, providing Mo powder with a purity of greater than or equal to 99.9%; S2, pretreating the Mo powder; and S3, preparing the alpha-MoC by adopting a low-temperature carbonization technology on the pretreated Mo powder. The application discards the traditional multi-step long process and high-temperature high-energy-consumption process, and solves the core pain points of low product purity, poor dispersity, serious pollution and difficulty in large-scale production in the prior art. The obtained alpha-MoC has a purity of greater than or equal to 95%, excellent catalytic activity, a preparation period shortened to 8-12 hours, energy consumption reduced by 70%, wastewater discharge reduced by more than 90%, and is suitable for industrial production and can be widely applied to thermal catalysis scenes such as CO2 resourceization, hydrogen production by reforming of low-carbon compounds, selective hydrogenation of unsaturated hydrocarbons and the like.

This invention belongs to the field of lignin catalytic conversion and utilization, and discloses a method for efficiently catalyzing the depolymerization of lignin using a copper-nickel bimetallic supported silicon-based catalyst. The method includes: adding woody biomass powder and a copper-nickel bimetallic supported silicon-based catalyst to a reaction solvent, and stirring the mixture in a high-pressure reactor under high temperature and high pressure conditions; after the reaction, allowing the reactor to cool naturally to room temperature, depressurizing, and filtering the resulting solid-liquid mixture; and then rotary evaporating the liquid portion to obtain lignin oil rich in monophenolic compounds, with a yield of up to 46.1 wt% under optimal conditions. The key technology of this invention is the efficient catalytic conversion of lignin into phenolic compounds without an external hydrogen source, while completely preserving cellulose and hemicellulose. This method is characterized by mild conditions, a simple and efficient separation process, and achieves efficient hydrogenation and deoxygenation of lignin components.

The application belongs to the field of organic synthesis and particularly relates to a synthesis method of meta-trifluoromethyl phenol, which comprises the following steps: (1) in a solvent, a Williamson reaction is carried out on meta-chlorotrifluoromethyl benzene and tert-butyl alcohol under the catalysis of sodium hydride and a metal acetate salt to prepare an intermediate meta-trifluoromethyl phenyl tert-butyl ether; and (2) in a solvent, the meta-trifluoromethyl phenyl tert-butyl ether prepared in step (1) is subjected to tert-butyl group removal under the action of ZSM-5 molecular sieve to prepare trifluoromethyl phenol. The synthesis method is simple in steps, low in cost and relatively environmentally friendly.

This invention discloses a method for the selective hydrogenolysis of lignin using alumina-supported nickel and nickel-tin alloy catalysts to prepare guaiacol monomers. The method employs a urea precipitation method to prepare a catalyst containing both metallic nickel and a nickel-tin alloy active phase. Organosoluble lignin is used as the raw material, and a mixture of alcohols and water is added as the solvent. The alumina-supported nickel and nickel-tin alloy catalyst prepared by the urea precipitation method is then added. The air in the reactor is replaced with an inert gas, and the pressure is increased to 1.0–3.0 MPa. The reactor is then stirred at 210–270°C for 1–6 hours, resulting in the highly selective conversion of organosoluble lignin into compounds primarily composed of guaiacol monomers. This invention features a simple catalyst preparation process, low cost, and a mild and safe lignin depolymerization reaction. The obtained guaiacol products can be used to prepare food additives or pharmaceutical intermediates and other chemicals.

The present application relates to the technical field of petroleum chemical industry, and discloses a kind of MTBE production line on-line disturbance depressurization method, comprising the following steps: S1, the processing capacity of feed pipeline is reduced;S2, adjust preheater to reduce preheating temperature;S3, adjust the outer circulation line connected with the reactor to be depressurized, so that the outlet temperature is 55-58 DEG C;S4, stop the outer circulation pump on the outer circulation line, and the stop duration is the first time period;S5, adjust the outer circulation line of the reactor closest to discharge valve, so that the outlet temperature of the reactor is between 60-65 DEG C;S6, open the outer circulation line of the outer circulation line connected with the reactor to be depressurized;S7, adjust preheater to control preheating temperature at 46-47 DEG C, adjust catalyst bed temperature at 58-62 DEG C, adjust the outlet temperature of the reactor closest to discharge valve between 50-60 DEG C, outlet pressure between 0.78-0.8 MPa, so that the pressure drop is less than 0.1 MPa.

The application belongs to the field of energy chemical industry, and discloses a method for preparing ethanol from CO2 via dimethyl ether and methyl acetate, which comprises the following steps: mixing CO2 with H2, and then performing a reaction in a first reactor filled with a first catalyst to obtain an intermediate product rich in dimethyl ether; performing a carbonylation reaction on the intermediate product rich in dimethyl ether and CO in a second reactor filled with a second catalyst to generate methyl acetate; and performing a hydrogenation reaction on the methyl acetate and hydrogen in a third reactor filled with a third catalyst to obtain ethanol. The application realizes the preparation of ethanol from CO2 via a three-stage production process of CO2 hydrogenation to produce dimethyl ether, dimethyl ether carbonylation to produce methyl acetate, and methyl acetate hydrogenation to produce ethanol. The complete production process can realize a CO2 conversion rate of more than 90% and an ethanol selectivity of more than 95%.

This invention relates to the field of chemical engineering, specifically to a method for the highly selective synthesis of high-quality ortho-vanillin. Using 3-methoxysalicylic acid as a starting material, a hydroxyl group protection reaction is performed under weakly alkaline conditions to generate compound 2. Compound 2 undergoes esterification, followed by reductive hydrogenation under a strong reducing agent to generate compound 3. In the presence of a nitrile radical catalyst, compound 3 reacts with an oxidizing agent to generate compound 4. In the presence of an acidic catalyst, compound 4 undergoes aldehyde group protection to generate compound 5. In the presence of a transition metal catalyst, the hydroxyl protecting group of compound 5 is removed to generate compound 6. Under strong acid conditions, compound 6 undergoes acetal hydrolysis to generate ortho-vanillin. This method achieves high regioselectivity and a simple process flow from the source through directional functional group transformation and protecting group strategies, avoiding the use of toxic and harmful reagents; it meets the requirements of industrial production for selectivity, environmental friendliness, and economy.

Processes are disclosed for the production of liquefied petroleum gas (LPG) hydrocarbons, utilizing both alcohol (e.g., methanol) synthesis and in situ dehydration of the alcohol to hydrocarbons, and particularly propane and / or butane. Operational adjustments and / or variations, involving activation of LPG synthesis catalyst systems at relatively high temperatures, followed by initial operation at relatively low temperatures, surprisingly lead to improvements in the stability of such catalyst systems. These improvements are often in conjunction with other benefits, for example greater selectivity and / or per-pass yield, with such improvements and benefits resulting from the ability to operate at reduced temperatures. Problems typically encountered in the art due to catalyst instability, such as the need for frequent replacement and / or regeneration, are thereby potentially reduced or even eliminated.

An amino group eliminating agent containing a compound (a) represented by the following Formula (a), which is used to produce a reaction product obtained by reacting an organic compound having an amino group with the amino group eliminating agent and additionally reacting the organic compound with a nucleophile:         Y1-X1-Rf-X2-Y2 ···     (a) in Formula (a), Rf is a substituted or unsubstituted divalent hydrocarbon group containing at least one fluorine atom; X1 and X2 are each independently a carbonyl group or a sulfonyl group; Y1 and Y2 are each independently a halogen atom or the like.

A catalyst body comprising: an amorphous support that is a single body containing a composite oxide that includes elemental aluminum and elemental silicon; and elemental copper that is dispersed in the support. A gas phase reaction device comprising: a reactor that forms a gas flow path; and a catalyst body that is provided in the reactor.

This invention relates to the field of methane partial oxidation technology, specifically to a Fe-CHA catalyst, its preparation method, and a method for methane partial oxidation. The Fe-CHA catalyst has a silicon-to-aluminum atomic ratio of 8-10; the Fe-CHA catalyst... 29 In the Si solid-state NMR, within the chemical shift range of -90 ppm to -120 ppm, there are four resonance peaks with increasing chemical shifts, δ1 to δ4. The normalized peak area of ​​δ1 is 6% ± 1%, that of δ2 is 8% ± 1%, that of δ3 is 11% ± 1%, and that of δ4 is 75% ± 1%. The content of tetrahedral coordination mononuclear Fe is 29%–31%, that of octahedral coordination mononuclear Fe is 47%–49%, and that of oligomeric Fe is 21%–23%. This catalyst, when used for the partial oxidation of methane, can achieve high methane conversion at low temperatures while also exhibiting high selectivity for methanol and dimethyl ether.

Methods for the production of syringol from biomass are provided. Reactive diluents derived from syringol and their use in 3D printing are also provided.

This invention discloses a fullerene C 60 Tetraaddition derivatives, their preparation methods, and applications. This fullerene C... 60 The tetraaddition derivative structure is shown in Formula I. The specific preparation method is as follows: under inert gas protection, using fullerene C 60 Using tetrabutylammonium hydroxide hydrate, benzyl bromide, and TBAOH methanol solution as raw materials, and o-dichlorobenzene or toluene as solvent, the reaction is carried out at 60–80 °C to obtain the target fullerene C. 60 Tetraaddition derivative. This fullerene C 60 The preparation method of the tetraaddition derivative has the advantages of simple operation steps, safety and easy control, and high selectivity. Photovoltaic devices fabricated using this fullerene derivative as an acceptor material exhibit high open-circuit voltage, making it a very promising photovoltaic material.

The application discloses a production method of high-purity chloromethyl ether, and belongs to the technical field of chloromethyl ether, wherein a composite special catalyst is added in the production process, so that the reaction path is accurately controlled, the generation of by-products such as polychlorinated compounds and oligomers is greatly reduced, and the product purity is improved; the composite special catalyst adopts iron-calcium double active sites to synergistically catalyze the chloromethylation reaction, and the existence of the double sites makes the catalytic efficiency high; the composite special catalyst takes a carbon fiber skeleton as a carrier, the carbon fiber skeleton has a high specific surface area and a porous structure, and after being modified on a calcium base, the pore distribution is uniform, so that the uniform loading of active components can be realized, the diffusion and contact of reactants can be accelerated, the reaction can be promoted, and the impurity content is reduced; and the carbon fiber skeleton has good mechanical stability, can be quickly separated through filtration after the reaction, and can be reused after regeneration treatment, so that the catalyst cost is reduced, solid waste emission is reduced, and the green chemical industry concept is met.