26 results about "Alkyl bromide" patented technology

The application discloses a kind of using cobalt catalyst by unreported double migration coupling strategy, realizes migration asymmetric nitrogen hetero Nozaki-Hiyama-Kishi (aza-NHK) reaction, and the selective preparation α-chiral (E)-allyl amine starting from simple and easy to obtain ortho halogen phenyl ethylene or corresponding E / Z-alkyl bromide or its mixture belongs to the field of organic chemistry and medicinal chemistry.The application under the action of metal cobalt source, ligand, organic additive, inorganic additive etc., makes cyclic sulfonamide and ortho alkenyl substituted aryl halide or alkenyl halide react in organic solvent, to obtain a series of polysubstituted olefins with excellent regioselectivity, stereoselectivity and good yield, which can be used as active drug molecules and important synthetic intermediates.The application uses cheap transition metal cobalt as catalyst, and uses ortho alkenyl substituted aryl iodine and cyclic sulfonamide as raw material, and the reaction condition is warm, simple operation, and good functional group compatibility.

The invention discloses a preparation method and application of a catalyst for synthesizing 6-aminocapronitrile, and belongs to the field of catalysis. Comprising the following steps: mixing a carrier with an alkyl ammonium bromide solution, carrying out hydrothermal modification, drying I and roasting to obtain a modified carrier; mixing an active component precursor solution with the modified carrier, dipping, and drying II to obtain a catalyst precursor; and carrying out water vapor treatment on the catalyst precursor to prepare the catalyst for synthesizing 6-aminocapronitrile. The preparation method has the advantages of simple preparation process, low cost and easiness in large-scale production.

The invention discloses a hydroxy sulfobetaine gemini surfactant, which is simply recorded as DTH-n, the synthesis method comprises the following steps: (1) adding N, N-dimethylethylenediamine and alkyl bromide (carbon chain lengths are respectively 10, 12, 14 and 16) into a reaction container, carrying out reflux stirring at 70 DEG C for 16-20 hours by taking absolute ethyl alcohol as a solvent and KOH as an alkaline agent, carrying out suction filtration, carrying out rotary evaporation on filtrate to remove the solvent, dissolving a product into n-hexane, adding concentrated hydrochloric acid, stirring to separate out a white solid, carrying out suction filtration to obtain a solid gemini alkyl tertiary amine acidified substance, and drying the solid gemini alkyl tertiary amine acidified substance; dissolving the solid acidified substance in absolute ethyl alcohol, carrying out liquid separation, taking a lower-layer solution, and adding solid KOH to reduce the gemini alkyl tertiary amine acidified substance into an intermediate product gemini alkyl tertiary amine under the protection condition of normal hexane; and (2) adding the product, 3-chloro-2-hydroxypropane sodium sulfonate and an isopropanol aqueous solution as a solvent and sodium carbonate as an alkaline agent into a reaction container to maintain the pH value of the reaction solution at 8-10, carrying out reflux reaction at 90 DEG C for 48 hours, separating liquid, taking a lower-layer solution, evaporating in a vacuum oven to remove the solvent, dissolving residues in a 70% ethanol solution, carrying out suction filtration, standing the filtrate at 0 DEG C for 12 hours, separating out a viscous oil substance, and drying to obtain the product. Separating liquid, re-precipitating and purifying, evaporating in a vacuum oven to remove the solvent, and grinding to obtain a faint yellow powdery solid. According to the invention, a two-step method is adopted, the reaction steps are few, the operation is simple, the product is easy to separate and purify, and the surface activity and foam performance are excellent.

The application provides a hydrophobic associating polymer and a preparation method thereof, and a polymer reinforced foam system, the hydrophobic associating polymer is copolymerized by a hydrophobic monomer and acrylamide and sodium acrylate; wherein the hydrophobic monomer is obtained by quaternary ammonium reaction of methacrylamidopropyl dimethyl amine and alkyl bromide with a molar ratio of 1:1-1.15. The foam system of the application has good foaming property and foam stability under strong oil wet conditions.

The invention belongs to the technical field of organic chemical synthesis, and discloses a synthesis method of an organosilicon compound. According to the invention, successful synthesis of the 1, 3-site double-silicon compound from acrylonitrile, chlorosilane and alkyl bromide at room temperature is realized for the first time, and the blank in the prior art is filled. The method provided by the invention has the advantages of mild process conditions, short flow, simple steps and wide substrate applicability, and meets industrial production requirements. Research finds that the yield of the product can reach 85%, and the generated alkyl silicon compound has wide application prospects in organic synthesis and drug research and development. Therefore, the method has important application value.

The present invention provides a culture medium for amplifying hematopoietic cells having cell division ability, the culture medium containing a compound (I) represented by formula (1) or a physiologically acceptable salt thereof: in the formula (1), R1, R2, and R3 are each independently any one of hydrogen, a linear or branched C1-C4 alkyl group, bromine, and iodine, R4 is any one of a linear or branched C1-C4 alkyl group, bromine, and iodine, and R1, R2, and R3 are each independently any one of hydrogen, linear or branched C1-C4 alkyl groups, bromine, and iodine. R5 is any one of oxygen, methylene and a chemical bond, R6 is hydrogen or-NH2, R7 is hydrogen or-COOH, and R6 and R7 are not hydrogen at the same time.

The application discloses a kind of filter aids for reducing iron ore pulp moisture content and preparation method thereof, belong to filter aid technical field.The filter aid is with starch as matrix, cooperate bromoalkane, bromo quaternary ammonium salt and other raw materials, by pre-oxidation, alkaline activation, double bromination grafting and post-processing are obtained;Among them, bromoalkane is the normal monovalent alkyl bromide of carbon chain length 8-14, and bromo quaternary ammonium salt is 2-bromoethyl trimethyl ammonium bromide or 6-bromoethyl trimethyl ammonium bromide.The present application realizes the synchronous grafting of hydrophobic alkyl chain and cationic quaternary ammonium salt through covalent bond, which can not only destroy the mineral surface hydration film and convert attached water, but also flocculate fine particles and impurities, and optimize the pore structure of filter cake.The filter aid solves the defects of single function and poor synergy of traditional technology, significantly improves the filtration efficiency, reduces the moisture content of filter cake and the turbidity of filtrate, and the raw materials are environmentally friendly, the preparation process is simple, suitable for industrial production, and suitable for iron ore pulp solid-liquid separation filtering scene.

The invention relates to a method for synergistically catalyzing a decarbonylation alkylation reaction of alkyl aldehyde through nickel electrochemistry, which comprises the following steps: in an inert solvent, under the action of a metal catalyst, a ligand, an electrode and an electrolyte, carrying out catalytic reaction on an aldehyde compound containing unsaturated alkyl and alkyl bromide to obtain an alkane compound. According to the present invention, the non-activated alkyl aldehyde is adopted as the alkylation reagent, the raw materials are easily available, the operation is simple, the condition is mild, the expensive active metal catalyst or additive is not required to participate in the reaction, the good atom economy is provided, the high value-added alkane compound is obtained under the cheap and easily available current condition, and the synthesis process is environmentally friendly.

The invention discloses a filter aid for reducing the water content of iron ore slurry and a preparation method of the filter aid, and belongs to the technical field of filter aids. The filter aid is prepared by taking starch as a matrix and cooperating with raw materials such as brominated alkane and brominated quaternary ammonium salt through pre-oxidation, alkaline activation, dibromo-grafting and post-treatment. Wherein the alkyl bromide is normal monoalkyl bromide with the carbon chain length of 8-14, and the brominated quaternary ammonium salt is 2-bromoethyl trimethyl ammonium bromide or 6-bromoethyl trimethyl ammonium bromide. Synchronous grafting of hydrophobic alkyl chains and cationic quaternary ammonium salt is achieved through covalent bonds, hydration membranes on the surfaces of minerals can be destroyed, attached water can be converted, fine particles and impurities can be flocculated, and the pore structure of a filter cake is optimized. The filter aid overcomes the defects that a traditional technology is single in function and poor in synergism, the filtering efficiency is remarkably improved, filter cake moisture and filtrate turbidity are reduced, raw materials are environmentally friendly, the preparation technology is simple, and the filter aid is suitable for industrial production and suitable for iron ore slurry solid-liquid separation and filtering scenes.

The invention provides a preparation method of polystyrene with controllable molecular weight, which comprises the following steps: under the protection of inert atmosphere, adding a reducing agent into a water-free and oxygen-free organic solvent, then adding a styrene monomer, a catalyst and a dormancy initiator, and controlling the temperature to carry out polymerization reaction; after the reaction is finished, terminating the reaction, and carrying out post-treatment to obtain polystyrene; wherein the catalyst is a copper bromide / pentamethyldiethylenetriamine complex; the dormancy initiator comprises any one or a combination of at least two of alkyl chloride, alkyl bromide or alkyl iodide; the reducing agent is graphene oxide grafted with a phenolic hydroxyl group, and the active component phenolic hydroxyl group is grafted on the carrier graphene oxide. The supported reducing agent is adopted, the dynamic environment of polymerization reaction is fundamentally changed, and the free radical concentration in the system is controlled at an extremely low level, so that the occurrence rate of side reaction is fundamentally and greatly reduced, and controllable molecular weight is realized; belongs to the technical field of organic synthesis.

The invention belongs to the technical field of organic chemical synthesis, and discloses a method for catalytically synthesizing a 1, 3-site silicon-boron compound by using transition metal. According to the invention, the successful synthesis of the 1, 3-site silicon-boron compound from acrylonitrile, halogenated silane and alkyl bromide at room temperature is realized for the first time, and the blank in the prior art is filled. The method provided by the invention has the advantages of mild process conditions, short flow, simple steps and wide substrate applicability, and meets industrial production requirements. Research finds that the yield of the product can reach 85%, and the generated alkyl silicon boron compound has wide application prospects in organic synthesis and drug research and development. Therefore, the method has important application value.

The invention discloses a micromolecular sizing agent, a synthesis method thereof, a sizing agent solution and application, and belongs to the technical field of papermaking chemicals. The sizing agent has a double-long-chain secondary amine structure as shown in a general formula R2N (C3H6) N (CH3) 2, in which R is long-chain alkyl CnH2n + 1, and n is 14, 16 or 18. The synthesis method of the micromolecular sizing agent comprises the following steps: mixing 3-dimethylaminopropylamine and alkyl bromide in a molar ratio of 1: (2.0-2.5), and adding absolute ethyl alcohol as a solvent to prepare a mixture; and carrying out a heating reflux reaction on the mixture, and after the reaction is completed, sequentially carrying out reduced pressure distillation and recrystallization to prepare the micromolecular sizing agent. A brand new physical and chemical mechanism of electrostatic anchoring-hydrophobic shielding is utilized, and cellulose-based materials such as paper and the like are efficiently and instantly endowed with excellent hydrophobic performance under a neutral or alkaline mild condition.

The invention specifically discloses a negative electrode material, a preparation method thereof and a battery using the negative electrode material. The negative electrode material comprises titanium diselenide, long-chain alkyl ammonium bromide and a carbon material. The long-chain alkyl ammonium bromide comprises at least one of hexadecyl trimethyl ammonium bromide, octadecyl trimethyl ammonium bromide and dodecyl trimethyl ammonium bromide; the carbon material comprises at least one of carbon spheres and carbon nanotubes. The anode material disclosed by the invention is excellent in electrochemical performance and cycle performance.

The application discloses a method for preparing star-shaped block copolymer based on light-controlled in-situ bromine-iodine conversion reversible-deactivation radical polymerization, which comprises the following steps: mixing and dissolving MMA, alkyl bromide initiator, iodide and amine catalyst, and obtaining star-shaped homopolymer through BIT-RDRP reaction under blue light irradiation; mixing and dissolving PEGMA300, iodide and amine catalyst, mixing with the star-shaped homopolymer, and obtaining amphiphilic star-shaped block copolymer through BIT-RDRP reaction under blue light irradiation. The BIT-RDRP reaction is adopted, and the BIT-RDRP reaction is introduced into a continuous flow micro-tube reactor to prepare amphiphilic star-shaped block copolymer with controllable block ratio; the method has the advantages of mild conditions, simple components and high efficiency, can realize continuous preparation, and provides a simple and efficient method for controllable large-scale preparation of star-shaped block copolymer.

The invention belongs to the technical field of heterocyclic compounds, and particularly relates to an indole derivative and a preparation method thereof. The preparation method comprises the following steps: uniformly stirring alkyl bromide, a catalyst, a ligand, alkali and a solvent to obtain a mixture; stirring and reacting the mixture under illumination to obtain a reactant; and performing post-treatment on reactants to obtain the indole derivative. The indole derivative prepared in the invention has a good inhibition effect on the growth of ovarian cancer SK-OV-3 cells; the synthesis process of the reaction substrate adopts the traditional substitution reaction or human-name reaction, so that the preparation cost is low, the yield is high, the process is simple, the method is suitable for large-scale production, and the potential application value is extremely high; the used raw materials are low in price and stable in property, and special preservation conditions are not needed; the reaction operation is simple, the reaction condition is mild, an additional heating source is not needed, and an efficient synthesis way is provided for preparing the indole derivative.

The invention belongs to the technical field of pharmaceutical chemicals, and particularly discloses a bicyclo [2.1. 1] hexane derivative as well as a preparation method and application thereof. The bicyclo [2.1. 1] hexane derivative is a compound as shown in a formula (I) or a formula (II), a pharmaceutically acceptable salt, a stereoisomer or an isotope label of the bicyclo [2.1. 1] hexane derivative, wherein R1 is optionally selected from C1-C6 alkyl groups, bromomethyl alkyl, benzyl alkyl, ester groups, acylamino and acyl groups; r2 is optionally selected from hydrogen, C1-C6 alkyl, benzyl alkyl, aryl, heteroaryl, alkenyl, halogen and silicon; r3 is optionally selected from hydrogen, C1-C6 alkyl, bromomethyl alkyl, benzyl alkyl, an ester group, an acylamino group, an acyl group, an amido group, a sulfenamide group, halogen and a carboxyl group; and R4 is optionally selected from C1-C6 alkyl, benzyl alkyl, aryl, heteroaryl and alkenyl. And the formula (II) can be obtained by carrying out half-pinacol intramolecular rearrangement on the formula (I). Tests prove that the compounds in the formula (I) and the formula (II) can be used for treating osteoarthritis diseases.

The invention belongs to a preparation method of pharmaceutical and chemical intermediates, and discloses a method for reductive silanization of activated olefin by nickel-catalyzed alpha-benzoyl alkyl bromide and chlorosilane, which comprises the following steps of: synthesizing the alpha-benzoyl alkyl bromide from alkyl aldehyde, reacting the alpha-benzoyl alkyl bromide serving as a reaction substrate and chlorosilane serving as a catalyst in the presence of a catalyst; a nickel catalysis technology is adopted to realize reductive silanization reaction of activated olefin. Compared with other synthesis methods, the alpha-benzoyl alkyl bromide synthesized by aldehyde is used as a reaction substrate and is a chemical which is wide and easy to obtain. Compared with a traditional synthesis method, nickel catalysis serves as a green energy source, the reaction condition where nickel catalysis participates is milder, functional group compatibility is better, and therefore a new thought is provided for efficient synthesis of the alkylsilane compound.

This invention relates to a tertiary alkylamine compound, its synthesis method, and its applications. The invention uses tertiary alkyl bromides and 3-substituted indole derivatives as substrates, reacting them at 40°C for 8-12 hours under the action of a catalyst, ligand, reducing agent, and additives to obtain tertiary alkylamines. This invention has advantages such as using inexpensive metal catalysts, readily available and simple raw materials, mild reaction conditions, simple steps, safe operation, and high yield.

The application discloses a method for continuously preparing star-shaped block copolymer based on organic catalytic atom transfer radical polymerization, which comprises the following steps: mixing and dissolving MMA, alkyl bromide initiator and organic catalyst, and obtaining star-shaped homopolymer through O-ATRP reaction under blue light irradiation; mixing and dissolving PEGMA300 and organic catalyst, mixing with the star-shaped homopolymer, and obtaining amphiphilic star-shaped block copolymer through O-ATRP reaction under blue light irradiation. The application introduces O-ATRP reaction into a continuous flow micro-tube reactor, and realizes efficient and controllable preparation of star-shaped block copolymer with different polymerization degrees and block ratios by adjusting the feeding of reactants, light irradiation conditions, reactor parameters and the sampling rate of reaction solution; the operation process is effectively simplified, the efficiency is improved, and the production scale is expanded; meanwhile, the conditions are mild, no transition metal is used, the components are simple, and the polymerization reaction rate is fast.

The invention relates to a preparation method and application of a caprolactam ammonification catalyst, and belongs to the field of catalysis. Comprising the following steps: a, mixing a carrier with an alkyl ammonium bromide solution, and carrying out hydrothermal modification, drying I and roasting to obtain a modified carrier; b, preparing an impregnation liquid from an active component precursor and a metal auxiliary agent precursor, mixing the impregnation liquid with the modified carrier, impregnating, and drying II to obtain a catalyst precursor; and c, carrying out water vapor treatment on the catalyst precursor to prepare the caprolactam ammoniation catalyst. The prepared caprolactam ammoniation catalyst is applied to a reaction for preparing 6-aminocapronitrile through caprolactam ammoniation, has high conversion rate and selectivity, also has high stability, and can stably operate for a long period.

This invention discloses a template composition for synthesizing high silica-to-alumina ratio ZSM-48 molecular sieves and its application method. The template composition consists of a reactant of an alkanolamine and a dihaloalkane as template A, and alkylammonium bromide as template B. Using this composition, high silica-to-alumina ratio ZSM-48 molecular sieves can be prepared. In the resulting high silica-to-alumina ZSM-48 molecular sieves, aluminum species preferentially accumulate in the near-port region of the one-dimensional channels, thereby precisely constructing efficient and accessible acidic sites. Catalysts prepared using this as a support can effectively improve the hydroisomerization and cracking capabilities of alkanes, and are particularly suitable for catalyzing the hydroisomerization reaction of long-chain alkanes.

The application discloses a compound demulsifier and a preparation method thereof, and belongs to the technical field of oilfield development. The compound demulsifier comprises the following components in parts by weight: 25-40 parts of sodium dioctyl sulfosuccinate, 20-33 parts of alkyl bromopyridine, 12-20 parts of esterified non-ionic polyether demulsifier, 5-10 parts of flocculant, 3-8 parts of oxidant, 1-5 parts of dispersant and 55-70 parts of alcohol solvent; wherein the molecular weight of the esterified non-ionic polyether demulsifier is 4200-6000. The compound demulsifier is prepared by compounding sodium dioctyl sulfosuccinate, alkyl bromopyridine and esterified non-ionic polyether demulsifier, and is used for demulsification of shale oil emulsion, so that the multilayer colloid interface film is layer by layer destroyed, and efficient demulsification is realized.

The invention relates to the technical field of chemical engineering, in particular to an N, N-dihexyl-3-methoxyaniline pure product, a preparation method and application. According to the method, in a polar aprotic solvent, inorganic base is used as a catalyst, 3-methoxyaniline and alkyl halide are catalyzed to perform alkylation reaction to obtain a product, and then the product is purified; the polar aprotic solvent is one or more of N, N-dimethyl formamide, dimethyl sulfoxide, N-methyl pyrrolidone or acetonitrile; the inorganic base is one or more of carbonate or hydroxide; the alkyl halide is one or more of alkyl bromide, alkyl chloride or alkyl iodide. The method has the advantages of mild reaction conditions, good selectivity and few byproducts; a green and economic process route suitable for large-scale production is provided for efficient synthesis of the N, N-dihexyl-3-methoxyaniline, and a technical support is provided for industrialization of the high-color-density fluorane dye.

The application belongs to the technical field of heterocyclic compounds, and particularly relates to an indole derivative and a preparation method thereof. Alkyl bromide, a catalyst, a ligand, a base and a solvent are uniformly stirred to obtain a mixture; the mixture is stirred to react under light to obtain a reactant; and the reactant is treated to obtain the indole derivative. The indole derivative prepared in the application has a good inhibitory effect on the growth of ovarian cancer SK-OV-3 cells; the synthesis process of the reaction substrate is all a traditional substitution reaction or a named reaction, the preparation cost is low, the yield is high, the process is simple, the application is suitable for large-scale production, has a very high potential application value, the raw materials used are low in price and stable in nature, do not need special storage conditions, the reaction operation is simple, the reaction condition is mild, and no additional heating source is needed, so that an efficient synthesis route for preparing the indole derivative is provided.

The invention discloses a preparation method of alkyl-substituted diaryl trivalent phosphine, which belongs to the technical field of organic synthesis, and comprises the following steps: under the protection of inert gas, mixing a nickel catalyst, a reducing agent, a nitrogen-containing ligand, an organic solvent, alkyl bromide and diaryl phosphorus chloride, reacting at-10-80 DEG C for 1-24 hours, filtering, washing, and drying to obtain the alkyl-substituted diaryl trivalent phosphine. And after the reaction is finished, adding a borane complexing agent for complexing treatment, and purifying to obtain the target phosphine compound. The preparation method of the alkyl-substituted diaryl trivalent phosphine disclosed by the invention is wide in raw material source, mild in condition, simple and convenient to operate, high in yield and good in functional group tolerance, and diaryl phosphorus chloride and alkyl bromide which are low in price and wide in source are adopted as starting raw materials; and a feasible solution is provided for large-scale preparation of the alkyl-substituted phosphine ligand with important value.

The present application relates to the technical field of organic synthesis, and particularly relates to a kind of boron-containing chiral allyl ester compound and high stereoselective synthesis method, comprising the following steps: under the action of catalyst, chiral diamine ligand and base, acetylene, boron reagent and alkyl bromide are dissolved in organic solvent and are reacted, and boron-containing chiral allyl ester compound is obtained by separation and purification.The method of the present application uses acetylene, alkyl bromide and double boron reagent, and boron-containing chiral allyl ester compound is prepared by one-step reaction under the synergistic effect of catalyst and diamine ligand, which can not only efficiently synthesize target compound, but also has mild reaction condition, strong substrate universality, good functional group compatibility, excellent chemical selectivity and stereoselectivity, and the highest ee value can reach 95%, the raw materials used are cheap and easy to obtain, and the operation is simple, so that boron-containing chiral allyl ester compound can be efficiently synthesized.