45 results about "Benzoyl bromide" patented technology

The invention provides a series of polybenzyl bromide or polybenzyl iodide-based monomolecular resin photoresists as well as a preparation method and application thereof. The monomolecular resin can be used as a main body material of the photoresists. The raw materials are cheap and easily available, and the synthesis process is simple. According to the compound disclosed by the invention, adamantane is taken as a core unit, a plurality of benzyl bromide or benzyl iodine groups, adamantane and a benzene ring are externally connected, and bromine atoms or iodine atoms are additionally introduced, so that the sensitivity and the etching resistance of the photoresist can be improved to the maximum extent.

The invention relates to the technical field of benzyl bromide preparation and discloses a benzyl bromide preparation device and method.The benzyl bromide preparation device comprises a stirring kettle, a heating box is fixedly connected to the outer wall of the stirring kettle, an isolation sleeve is fixedly connected to the inner wall of the stirring kettle, a water inlet pipe is fixedly connected to the upper surface of the heating box, and a water outlet pipe is fixedly connected to the lower surface of the heating box; one end of the water inlet pipe penetrates through the surface of the heating box and is fixedly connected with a water pump, a supporting plate is fixedly connected into the heating box, the water pump is installed on the surface of the supporting plate, and the middle of the heating box is connected with a heating assembly. The bottom of the isolation sleeve is connected with a temperature measuring assembly, and the inner wall of the isolation sleeve is connected with a scraping assembly. According to the preparation device and the preparation method of the benzyl bromide, reaction materials in the stirring kettle can be uniformly heated, so that the reaction uniformity is improved, and an overheating or supercooling phenomenon of a local area is avoided.

The application discloses a kind of breathable antibacterial fabric and its preparation process, S1, nylon is used as warp and tension is maintained;S2, spandex is used as weft, and weft and warp are interwoven into grey cloth;S3, the grey cloth is finished by finishing agent, the burr is cut, and the wrinkle is smoothed, to obtain fabric, using hexamethylene diisocyanate, 3-hydroxypropionic acid is reacted to obtain hexamethylene di (carbamate propionic acid), after acyl chloride, and with N-methyl-2,2-diamino diethylamine, benzyl bromide is reacted, to obtain antibacterial finishing agent.It contains a large number of quaternary ammonium salt antibacterial groups, and has inhibitory and killing effect on bacteria such as escherichia coli, and at the same time contains polyamide and urethane structure, and has high affinity and interfacial force between the polyamide molecular chain in the blended fabric and the urethane structure of spandex polyurethane, to improve the firmness of antibacterial finishing agent attached to the surface of fabric and antibacterial time effect.

The invention relates to the technical field of pesticide synthesis processes, in particular to a one-pot multi-component preparation method of a chiral Dufulin compound. The method comprises the following steps: mixing quinine, substituted benzyl bromide and a solvent, and refluxing to obtain a reaction solution; the preparation method comprises the following steps: mixing 2-amino-4-methylbenzothiazole, 2-fluorobenzaldehyde, a solvent and a catalyst, and then refluxing to obtain a reaction system; mixing the reaction system with diethyl phosphite, the reaction liquid and an alkali reagent, and stirring to react, so as to obtain a stirred reaction material; and extracting the stirred reaction material with an extraction liquid, separating the liquid to obtain an organic phase, washing the organic phase with water, and removing the solvent to obtain the chiral Dufulin compound. According to the invention, low-cost clean synthesis of chiral Dufulin is realized; the preparation method disclosed by the invention is reasonable in design, mild in reaction condition, easy to obtain raw materials, convenient to operate, high in product yield, suitable for large-scale production and good in industrial replicability.

The invention discloses bio-based polyamide with low water absorption and a preparation method thereof, and belongs to the technical field of polyamide preparation. The bio-based polyamide with the low water absorption rate is prepared from the following components in parts by weight: 30 to 50 parts of pentamethylene diamine, 15 to 30 parts of sebacic acid, 5 to 12 parts of citric acid, 5 to 10 parts of hexamethylenediamine, 2 to 5 parts of a hydrophobic auxiliary agent and 1 to 5 parts of a modified high-temperature-resistant additive, the hydrophobic additive is prepared from acetoxybenzoic acid, nonadecanoic acid, m-dimethoxybenzene, trifluoroacetic anhydride and methyl tert-butyl ether as raw materials, and the modified high-temperature-resistant additive is prepared from o-phenylenediamine, chloroacetic acid, vanillin, benzoyl bromide and thiourea as raw materials. The bio-based polyamide prepared from the substances has low water absorption and excellent thermal stability.

This invention relates to the field of oilfield chemical additives technology, and discloses a method for preparing a 1-benzyl-10-phenylpyrrolo[1,2-a:3,4-b']dipyrazine-1-onium type quaternary ammonium salt high-temperature acidizing corrosion inhibitor. The method uses 2,2'-piperazine as the starting material, which undergoes a quaternization reaction with benzyl bromide to obtain a quaternary ammonium salt intermediate. The obtained intermediate undergoes an oxidative cyclization reaction with benzaldehyde and manganese dioxide in a dichloromethane system. After separation, drying, and purification, the target product is obtained. The preparation process of this invention is simple and easy to control, the product is easy to purify, and it is suitable for industrial production. It exhibits good synergistic effects with additives, excellent water solubility and compatibility, can stabilize and protect steel, reduce construction risks, and is suitable for various high-temperature acidizing operations.

There is disclosed a method of preparing a compound of Formula (1), or a salt thereof (1) the method comprising: a) treating a compound of Formula (2) sequentially with o-tolylmagnesium chloride, N-methylpiperazine and iodine, under conditions sufficient to obtain a compound of Formula (3) b) treating the compound of Formula (3) from step a) with 3,5-bis(trifluoromethyl)benzyl bromide and a suitable base, under conditions sufficient to obtain a compound of Formula (1).

The invention discloses a 5-hydroxypyrazole compound as well as a synthesis method and application thereof, and the structural formula of the 5-hydroxypyrazole compound is as follows: 3-phenoxyphenyl-3-oxo-methyl propionate derivative is used as a starting material, the starting material and benzyl bromide derivative are subjected to hydrocarbylation reaction firstly, then the starting material and hydrazine hydrate are subjected to Knorr reaction, and the 5-hydroxypyrazole compound is obtained. Finally, the 5-hydroxy-3-phenoxyphenyl pyrazole ring compound is prepared, and the prepared 5-hydroxypyrazole ring compound shows that the 5-hydroxypyrazole ring compound has a good inhibition effect on HepG2 cells and can be used for further preparing anti-cancer drugs.

The application provides a series of monomolecular resin photoresists based on polybenzyl bromide or polybenzyl iodine and a preparation method and application thereof, and the monomolecular resin can be used as a main body material of the photoresist. Raw materials are cheap and easy to obtain, and the synthesis process is simple. The compound provided by the application takes adamantane as a core unit, is externally connected with multiple benzyl bromide or benzyl iodine groups, and the core structure of adamantane and benzene ring and the introduction of bromine atoms or iodine atoms can maximize the sensitivity and etching resistance of the photoresist.

The application belongs to the technical field of chemical industry and relates to a preparation method of a novel chiral bipyridine and application of the chiral bipyridine in catalytic reaction. Various benzyl bromides with 4,5-diazofluorene as a skeleton are reacted to generate a series of chiral bipyridine ligands, then under the participation of the ligands, indolines and quinoline nitrogen-containing heterocyclic compounds are reacted with pinacol diboronic acid under the catalysis of [IrOMe(COD)2] as a metal catalyst, and then a series of phenol compounds are obtained through oxidation of sodium perborate. The novel chiral bipyridine ligand developed by the method has the advantages of good site selectivity and excellent reaction yield without using strong acid and strong base in the process of C-H bond selective boronation.

This invention discloses a method for preparing high-purity quartz sand from quartz ore, relating to the field of high-purity quartz sand processing. First, a quaternized cation reagent is prepared using benzyl bromide and N,N-dimethyldodecylamine as raw materials. The adsorption of this self-made collector on the quartz surface is the result of the combined effects of electrostatic attraction and multiple forms of hydrogen bonding. The addition of quaternary ammonium and polyhydroxy groups allows for strong physical adsorption of quartz without the need for strong acids. Furthermore, a stable filler layer is formed on the quartz surface, thereby improving the collection effect of the quartz sand. Secondly, the preparation process of this invention is as follows: coarse washing – coarse crushing – direct high-temperature bursting water quenching – medium crushing – microwave heating – fine crushing – acid leaching – magnetic separation – flotation – drying. A segmented, step-by-step treatment is adopted, using different treatment methods for different particle sizes of quartz sand, which is beneficial for removing inclusions in the quartz and results in a larger surface area and better effect compared to acid leaching. The quartz sand prepared by this invention exhibits high purity.

The invention discloses a cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound as well as a synthesis method and antibacterial application thereof, and belongs to the technical field of plant antibiosis. Hydronopyl chloride and tetrahydropyrrole are taken as raw materials, an N-hydronopyl tetrahydropyrrole intermediate is prepared through reaction, and the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound is prepared through a one-step reaction. Then, the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound and an alpha-bromoacetophenone compound or a benzyl bromide compound are subjected to a quaternization reaction, and the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound can be synthesized; the cyclic quaternary ammonium salt N-hydronopyl tetrahydropyrrole compound has excellent broad-spectrum antibacterial activity, and especially has a remarkable inhibition effect on common phytopathogens such as rhizoctonia solani, oxysporum tomentosum, colletotrichum carpopogonum, fusarium oxysporum, tobacco black shank, Fusarium fulvum, coriolus versicolor, fusarium verticillium and the like.

The invention discloses a preparation method of a luminescent compound. The preparation method comprises the following steps: step 1, reducing a raw material a by a reducing agent to generate a compound b; 2, reacting the compound b with benzyl bromide to generate a compound c; 3, reacting the compound c with methyl dithioacetate under photocatalysis to generate a target product compound d; according to the present invention, the reaction conditions are mild, the green reaction modes such as photocatalysis are adopted, the good yield can be obtained while the mild reaction conditions are ensured, the method is suitable for the luminescent substrates with various structures, and the application range is expanded.

The application discloses a selenium-substituted hemicyanine dye precursor and a synthesis method and application thereof, and belongs to the fine chemical field. The structure of the selenium-substituted hemicyanine dye precursor is shown in a general formula I. In the general formula I, R1 is one of H, a phenyl group, a p-phenyl benzyl chloride, a p-phenyl benzyl bromide, SO3R4, COOR4 or C1-C 12 alkyl; R2 is C, S or Se; R3 is one of H, a phenyl group or C1-C 12 alkyl; R4 is H or C1-C 12 alkyl; and Y is Cl, Br or I. The application provides a selenium-substituted hemicyanine dye precursor, which has near-infrared absorption and emission spectral performance and high active oxygen generation capacity, and provides an ideal platform for constructing dye photosensitizers.

The invention provides a fluorine-functionalized super-crosslinking material, a preparation method thereof and application of the fluorine-functionalized super-crosslinking material in cold-assisted solid-phase microextraction. The invention belongs to the technical field of headspace solid-phase microextraction. The fluorine-functionalized super-crosslinked coating is prepared by carrying out a reaction on C-methyl calix [4] hydrocarbon resorcinol, 4-(trifluoromethyl) benzyl bromide, ferric trichloride and dichloroethane in an oil bath at the temperature of 100 DEG C. The fluorine-functionalized super-crosslinking coating can be used for preparing a solid-phase micro-extraction fiber coating, and the solid-phase micro-extraction fiber coating can realize efficient adsorption of polychlorinated naphthalene through F-pi bonds, electrostatic adsorption and other acting forces. The invention further provides a self-made portable cold-assisted solid-phase microextraction device which can assist in extraction of high-boiling-point components in polychlorinated naphthalene. Compared with other solid-phase microextraction cold auxiliary devices, the solid-phase microextraction cold auxiliary device is simple in structure, convenient to operate and convenient to commercialize. The method has a wide application prospect in the aspects of environmental monitoring, food safety and the like.

The invention provides a preparation method of a key intermediate of a gemfibrozil impurity A, and belongs to the technical field of chemical synthesis. According to the invention, a brand-new synthetic route of the gemfibrozil impurity A is designed firstly, and efficient preparation methods of three key intermediates are provided on the basis of the brand-new synthetic route. Specifically, the preparation method comprises the following steps: firstly, reacting with propionyl chloride in a 1, 2-dichloroethane environment under the catalysis of aluminum trichloride, and cooling, layering and drying a product to obtain a first intermediate; taking the first intermediate as a raw material, reacting with benzyl bromide in a DMF (Dimethyl Formamide) environment by taking potassium carbonate as an acid-binding agent, collecting an organic phase, dissolving with methanol, carrying out reduction reaction by using sodium borohydride under the catalysis of cerium chloride heptahydrate, and collecting to obtain a second intermediate; taking the second intermediate as a raw material, dissolving the second intermediate in methylbenzene, and performing dehydration reaction under the catalysis of TsOH.H2O to obtain a third intermediate; on the basis of the three intermediates, efficient synthesis of the gemfibrozil impurity A can be achieved, the synthesis route is short, and the process efficiency is high.

The application provides a fluorescent probe based on a cinnamic acid derivative as well as a synthesis method and application thereof, and relates to the technical field of synthesis of specific probes. The fluorescent probe is prepared by introducing benzyl bromide into the hydroxyl group of a modified structure compound FHA using p-hydroxycinnamic acid as raw material, and a novel bifunctional fluorescent probe capable of specifically detecting Al 3＋ and N2H4 is developed. The application overcomes the defects of the prior art, the probe can specifically detect Al 3+ and N2H4, and has the characteristics of low detection limit, short response time, wide pH application range and the like; the probe has the characteristics of good biocompatibility, small toxicity, good optical properties and the like, and can be applied to cell imaging experiments.

The invention relates to a method for synthesizing benzoate derivatives from dimethyl sulfoxide, belongs to the technical field of application of organic sulfides, and solves the technical problems that existing aryl formate synthesis generally needs strong acid or strong alkali, synthetic products and synthetic conditions are limited and the like. The solution is as follows: the method for synthesizing benzoate derivatives from dimethyl sulfoxide comprises the following steps: 1) preparing benzyl methyl sulfide: putting dimethyl sulfoxide and benzyl bromide or benzyl bromide derivatives into a reaction container, and fully reacting at a first temperature to prepare benzyl methyl sulfide; and 2) preparation of the benzoate derivative: putting a photosensitizer, an inorganic base, an organic solvent, the benzyl methyl sulfide prepared in the step 1) and an organic bromide into a reaction container, and fully reacting under the irradiation of a visible light range at a second temperature and a target atmosphere condition to prepare the benzoate derivative. Compared with the prior art, the method has the advantages of high efficiency, greenness, economy, mild conditions, high social and economic benefits and the like.

The invention relates to a large Stokes shift cholinesterase near-infrared fluorescent probe and a construction method thereof.Quinoline is used as a core skeleton, and a conjugated system is constructed through a D-pi-A electronic regulation strategy: aryl, alkenyl or amido is introduced to the 4th site / 6th site to regulate the emission wavelength; the construction method comprises the following steps: synthesizing a fluorophore main skeleton through a Wittig reaction / Heck reaction, connecting a recognition unit through a substitution reaction, and introducing the electron-withdrawing group through a Najing condensation reaction. Stokes shift breaks through 100 nm, and excitation light interference can be inhibited. According to the probe, a recognition unit simulating acetylcholine / butyrylcholine'dumbbell-shaped 'conformation is covalently connected to a quinoline nitrogen atom through a benzyl bromide group, the recognition unit comprises an aromatic cavity adaptive to AChE / BChE substrate pocket hydrophobicity and an active site for catalyzing ester bond hydrolysis, an enzymatic reaction triggers intramolecular electron rearrangement and C-N bond breakage, a fluorescence quenching state is relieved, and the quinoline nitrogen atom can be detected. And "off-on" type signal conversion is realized.

The invention provides a synthetic method of a gemfibrozil impurity A, and belongs to the technical field of chemical synthesis. According to the technical scheme, gemfibrozil is used as an initial raw material and firstly reacts with propionyl chloride in a 1, 2-dichloroethane environment under the catalysis of aluminum trichloride, a product reacts with benzyl bromide in a DMF environment by taking potassium carbonate as an acid-binding agent, an organic phase is collected and dissolved with methanol, and then reduction reaction is performed with sodium borohydride under the catalysis of cerium chloride heptahydrate to obtain gemfibrozil. Collecting to obtain an oily liquid compound, dissolving the oily liquid compound in toluene, carrying out a dehydration reaction under the catalysis of TsOH.H2O, carrying out a hydrolysis reaction on the reaction product in an isopropanol and sodium hydroxide system, carrying out reduced pressure distillation to remove isopropanol, carrying out acid adjustment, extracting with ethyl acetate, drying with sodium sulfate, filtering, concentrating to obtain a white solid, and finally refining and purifying to obtain the 2-(2, 4-dichlorophenyl)-1, 2, 3, 4, 5-tetramethyl-1, 3-pentanediol. A gemfibrozil impurity A finished product is obtained. The method is short in synthetic route, high in process efficiency, convenient to refine and purify and high in yield and purity, and has outstanding technical advantages.

The invention discloses a preparation method of phentolamine EP impurity acid salt, which comprises the following steps: (1) taking a compound I resorcinol and a compound II p-toluidine as raw materials, and performing dehydration reaction to obtain an intermediate product III; (2) carrying out nucleophilic substitution reaction on the intermediate product III and benzyl bromide to generate an intermediate product IV; (3) carrying out nucleophilic substitution reaction on the intermediate product IV and ethyl bromoacetate to obtain an intermediate product V; (4) carrying out ester amidation reaction on the intermediate product V and N-tert-butyloxycarbonyl-1, 2-ethylenediamine to obtain an intermediate product VI; and (5) taking the intermediate product VI, and carrying out deprotection reaction to obtain a final product VII, wherein X represents hydrochloric acid, sulfuric acid, acetic acid, formic acid or trifluoroacetic acid. The purity of the prepared phentolamine EP impurity acid salt reaches 99% or above, the reaction yield is high, a test sample is provided for phentolamine research, and the phentolamine EP impurity acid salt has important research value in clinical pharmacokinetic research.

The invention belongs to the field of rubber materials, and provides a rubber composition for a tire steel wire belt layer and a preparation method thereof, and the rubber composition comprises 70-90 parts of natural rubber, 20-40 parts of epoxidized natural rubber, 5-7 parts of a tackifying system, 50-65 parts of carbon black, 2-5 parts of an anti-aging agent, and 4-6 parts of a sulfur system. The tackifying system is prepared through a reaction of benzimidazole, a thiuram compound and omega-brominated fatty acid benzyl ester, and the omega-brominated fatty acid benzyl ester is prepared through a nucleophilic substitution reaction of omega-brominated fatty acid and benzyl bromide. Benzimidazole and a thiuram compound are bridged through a flexible aliphatic chain to form a tackifying system molecule, and the molecule can be chelated with copper / zinc / iron and other metal ions on the surface of a steel wire through a benzimidazole part, so that the initial bonding strength between rubber and the steel wire is improved; the thiuram part improves the interface stress distribution of the steel wire belt layer rubber and the steel wire, and the bonding performance of the steel wire cord fabric layer is improved.

This invention provides a method for synthesizing polynitrogen heterocyclic carbene copper materials and their applications, overcoming the shortcomings of existing methods that produce polynitrogen heterocyclic carbene copper complexes with mostly irregular morphologies. This invention achieves the controllable construction of rod-shaped, sheet-like, and spherical polynitrogen heterocyclic carbene copper materials through a universal method. Firstly, molecules with benzyl bromide groups are used as linkers, imidazole molecules as monomers, and acetonitrile or 1,4-dioxane as solvent I. Through the coordination between different types of linkers, monomers, and solvent I, the growth rates v in the x, y, and z directions are effectively controlled during the quaternization and self-assembly process of the linkers and monomers. x v y v z It is possible to controllably prepare polyimide salts in the form of rods, sheets, or spheres; then, under the protection of an inert atmosphere, using the polyimide salt as a backbone, the imidazole salt is deprotonated and coordinated with the copper salt under alkaline conditions to controllably construct rod-shaped, sheet-shaped, or spherical polyazo heterocyclic carbene copper materials.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of absolute chiral 2-hydroxyhexahydro-1H-pyridine cyclo-7a-formic acid. The preparation method comprises the following steps: reacting 1-Boc-4-hydroxypyrrolidine-2-formic acid with benzyl bromide to obtain a first intermediate product; reacting the first intermediate product with 1, 3-dibromopropane to obtain a second intermediate product; reacting the second intermediate product with trifluoroacetic acid to obtain a third intermediate product; adjusting the pH value of the aqueous solution of the third intermediate product to be greater than or equal to 11 to obtain a fourth intermediate product; reacting the fourth intermediate product with a chiral agent to obtain a fifth intermediate product; and carrying out a reaction on the fifth intermediate product under a hydrogen condition to obtain the absolute chiral 2-hydroxyhexahydro-1H-pyridine cyclo-7a-formic acid. The absolutely chiral 2-hydroxyhexahydro-1H-pyridine cyclo-7a-formic acid product is prepared by reasonably optimizing the reaction process and adopting the simple reaction process, and is suitable for industrial application.

The application discloses a synthesis method of 3-(benzyloxy)-1-cyclobutanone. The application relates to the technical field of organic chemical synthesis. The application takes epichlorohydrin as raw material, and first obtains compound (I) by opening ring through benzyl bromide; then, the compound (I) is ring-closed into cyclobutane (II) under alkaline conditions by reacting with diethyl malonate; compound (II) is hydrolyzed and decarboxylated to generate compound (III); then, the carboxylic acid is converted into an amino compound (IV) by performing Curtius rearrangement; finally, the amino group is obtained by oxidation to generate 3-(benzyloxy)-1-cyclobutanone (V). The application provides a simple and convenient industrial production route of 3-(benzyloxy)-1-cyclobutanone, and has the advantages of simple reaction operation, convenient post-treatment, low cost and good industrial production prospect.

The invention belongs to the field of chemical analysis and testing, and particularly relates to a resorufin fluorescent probe for specifically recognizing peroxynitrite (ONOO) based on 4-(trifluoromethyl) benzyl bromide and application of the resorufin fluorescent probe. Resorufin and 4-(trifluoromethyl) benzyl bromide are dissolved in dimethylformamide (DMF), and reaction liquid is subjected to a water bath reaction for 8-10 hours at the temperature of 50-60 DEG C under the alkaline condition of potassium carbonate. An obtained crude product is separated and purified through thin layer chromatography, and the resorufin fluorescent probe HRA-1 based on 4-(trifluoromethyl) benzyl bromide is obtained. The resorufin fluorescent probe HRA-1 based on 4-(trifluoromethyl) benzyl bromide can realize high-sensitivity and high-specificity fluorescent response to peroxynitrite (ONOO-) in a dimethyl sulfoxide (DMSO) solution, the response time is short, and the operation is simple and convenient.

The present application relates to a kind of cation macrocycle photosensitizer and its preparation method and application;Through triphenylamine derivative and p-benzyl bromide synthesis four cation macrocycle 1 molecule, 1 can be used as photosensitizer, the molecule can be through I / II type light reaction path to produce active oxygen, and under the condition of oxygen deficiency, biological molecule (NADH, BH4) is damaged to a large extent.In addition, further through the acylhydrazone bond of pH response, the polyethylene glycol (PEG) chain is modified on the molecule, obtains polyethylene glycol modified four cation macrocycle 1-PEG, through macrocyclic cation cavity, load tumor drug, self-assembly forms supramolecular nanoparticle, realizes the combined treatment of photodynamic and drug, system has remote operation and non-invasive, with drug release and acylhydrazone bond break, fluorescence emission intensity also gradually enhances, can be effectively navigated by fluorescence imaging drug treatment to tumor, thus it has wide application prospect in cancer diagnosis and treatment.

The invention belongs to the technical field of biomedicine synthesis, and particularly relates to the technical field of chemical synthesis of natural drugs / prodrugs for controlling metabolic abnormalities such as blood sugar and blood fat. The invention provides a preparation method of a cholic acid derivative. The preparation method comprises the following steps: adding benzyl bromide into an alkaline solution containing cholic acid to obtain benzyl cholate; the method comprises the following steps: adding a dichloromethane solution containing acyl chloride into a dichloromethane solution containing benzyl cholate and 4-dimethylaminopyridine under protective gas to obtain a colorless oily product; and introducing hydrogen into the absolute ethyl alcohol in which the colorless oily product is dissolved to obtain the cholic acid derivative. The chemical synthesis of the cholic acid derivative is realized.

The invention provides a fluorescent probe based on a cinnamic acid derivative as well as a synthesis method and application of the fluorescent probe, and relates to the technical field of synthesis of specific probes. The fluorescent probe is a novel bifunctional fluorescent probe capable of specifically detecting Al < 3 + > and N2H4, which is developed by taking p-hydroxycinnamic acid as a raw material and introducing benzyl bromide into a hydroxyl site of a modified structural compound FHA. The probe overcomes the defects in the prior art, can specifically detect Al < 3 + > and N2H4, and has the characteristics of low detection limit, short response time, wide pH application range and the like; and the probe has the characteristics of good biocompatibility, low toxicity, good optical property and the like, and can be applied to cell imaging experiments.

The invention discloses a strong-alkali-resistant composite nanofiltration membrane as well as a preparation method and application thereof. The strong-alkali-resistant composite nanofiltration membrane comprises a porous support layer and a compact separation layer which are sequentially stacked, wherein the dense separation layer is formed on the surface of the porous supporting layer through interfacial polymerization of a water-phase monomer and an oil-phase monomer, the water-phase monomer comprises an amine monomer, the oil-phase monomer comprises a benzyl bromide monomer, and the benzyl bromide monomer has a plurality of benzyl bromide groups. The strong-alkali-resistant composite nanofiltration membrane is soaked in a 3-5 mol / L NaOH solution for a long time, so that the structural performance is stable, and the retention rate of the strong-alkali-resistant composite nanofiltration membrane on lignin is only 10%-15% while the retention rate of the strong-alkali-resistant composite nanofiltration membrane on NaOH is 95% or above; meanwhile, the composite nanofiltration membrane disclosed by the invention has excellent strong alkali resistance, not only shows excellent separation selectivity to lignin / alkali liquor, but also has great application potential in the aspects of separation of other substances and purification and recovery of alkali liquor in a strong alkali environment.