Method for preparing multifunctional multilayer micro/nanometer core-shell structure

A nano-core-shell and core-shell structure technology is applied in the field of preparation of micro/nano materials, which can solve the problems of difficulty in controlling particle morphology, restricting the types of materials used, easy agglomeration of particles, etc., and achieves good application prospects, strong applicability, and operation. Process controllable effect

Inactive Publication Date: 2015-04-01
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes new ways to make small molecular weight (MW), high specificity nanoparticles called quantum dots or magnetolets, while also controllably deliver them through an electric spray gun. These tiny particles have unique features like self-assembly ability, surface charge density, size ratio, etc., making their use across diverse areas including medicine, healthcare, environmental science, electronics, medical devices, and others. They may include hydrophobic substances, organophosphorus pesticides, antimicrotankments, and pharmaceutical compositions containing these active ingredients. Overall, this technology allows us to create advanced medications with improved safety and effectiveness without causing harmful reactions.

Problems solved by technology

This patents describes various techniques for producing small micron sized cores called "multiplex” cores - those made up of several layers of atoms and magnetons mixed together – specifically focusing on creation of multicoat type membranes containing hydrophobic functional groups like silicon oxides and iron oxanes while protecting them against damage during handling processes. These cores may contain embedded fluorescent agents, antimony powders, metal flakes, and platins. They offer unique fused heterogeneous compositions with enhanced functionality compared to traditional mixtures.

Method used

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  • Method for preparing multifunctional multilayer micro/nanometer core-shell structure
  • Method for preparing multifunctional multilayer micro/nanometer core-shell structure
  • Method for preparing multifunctional multilayer micro/nanometer core-shell structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Experimental device according to figure 1 Build as shown. Experimental materials Polyε-caprolactone (average molecular weight 45,000) and dye rhodamine B were purchased from Aldrich Co. (USA). Prepare a solution with a mass fraction of PCL of 5%, use dichloromethane as a solvent, and stir on a magnetic stirrer at a speed of 200 r / min for 20 minutes to obtain a colorless and transparent solution, and add 0.05 mg of the dye Rhodamine B to it , after stirring evenly, it was used as the inner layer solution of electrospray; olive oil was not treated as the middle layer solution of electrospray; a solution with a mass fraction of polyε-caprolactone of 5% was prepared, and dichloromethane was used as a solvent in a magnetic stirrer Stir at a speed of 200 r / min for 20 minutes to obtain a colorless transparent solution, which is used as the outer layer solution of electrospray after being stirred evenly.

[0059] Transfer the prepared electrospray liquid into a syringe (5 ml)...

Embodiment 2

[0061] Prepare a solution with a mass fraction of polyε-caprolactone of 5%, using dichloromethane as a solvent, and stirring at a speed of 200 r / min on a magnetic stirrer for 20 minutes to obtain a colorless and transparent solution, and polyε-caprolactone according to the mass ratio - Caprolactone solution: Fe 3 o 4: Tween 80 = 96:3:1 Stir several materials evenly, this solution is used as the outermost layer solution of EFI; mineral oil is not treated as the middle layer solution of EFI; the mass fraction of polyε-caprolactone is prepared to be 5 % solution of 10 ml, using dichloromethane as a solvent, and adding 0.05 g of paclitaxel drug in it, after stirring evenly, this solution was used as the innermost solution of electrospray.

[0062] Transfer the prepared electrospray solution into a syringe (5 ml), connect it to the outer, middle and inner channels of the ternary coaxial needle through silicone tubes, adjust the speed of the syringe pump, and adjust the flow rates ...

Embodiment 3

[0064] Prepare a solution with a mass fraction of polylactic acid-glycolic acid copolymer of 5%, using dichloromethane as a solvent, and stirring at a speed of 200 r / min on a magnetic stirrer for 20 minutes to obtain a colorless and transparent solution, which is used as an electrospray The outermost layer solution; the silicone oil is not treated as the middle layer solution of electrospray; prepare a solution with a chitin mass fraction of 7%, use trifluoroacetic acid as a solvent, and stir for 20 minutes at a speed of 200 r / min on a magnetic stirrer , to obtain a colorless transparent solution, and according to the mass ratio of chitin solution: Fe 3 o 4 : Tween 80 =96:3:1 Stir several materials evenly, this solution is used as the innermost solution of electrospray.

[0065] Transfer the prepared electrospray liquid into a syringe (5 ml), and connect it to the outer, middle, and inner channels of the three-way coaxial needle respectively through the silicone tube. The thr...

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Abstract

The invention relates to a method for preparing multifunctional three-layer core-shell structure micro/nano particles. The particles are of spherical structures, the thickness of each shell layer is controllable, multiple materials or medicines having different properties can be effectively and independently coated simultaneously, multifunctional characteristic compounding can be realized by adding functional auxiliary materials into each phase, the advantages of multilayer core-shell structures and excellent optical, electrical, magnetic, acoustic and biological characteristics are integrated into a whole, drug controlled release and medical contrast imaging application can be realized, and particularly the core-shell structure has excellent application prospects in the aspects of disease treatment and medical imaging. The preparation method is a coaxial electrostatic spraying method, the process and equipment are simple, the generated particles are controllable in forms, the particle size, shape and core-shell thickness of the obtained core-shell structure particles can be controlled by changing the operating parameters, the particle size is uniform, and the core-shell structure has good application prospects. In addition, the core-shell structure particles can serve as a precursor for preparing a hollow and special ring structure.

Description

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Claims

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Application Information

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Owner ZHEJIANG UNIV
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