Implantation body with biological activity of drug controlled-releasing function, its controlled releasing method and preparing method

A bioactive, drug-controlled release technology, applied in the field of magnetic fields, can solve the problems of patient inconvenience, increased clinical use, and increased use costs

Inactive Publication Date: 2006-02-15
罗聪 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the working principles of these two types of drug release systems are different, they have a common deficiency, that is, after the loaded drug is released, the implanted drug release system must be removed by surgery.
This increases the cost of use and increases the difficulty of clinical use, especially bringing more inconvenience and pain to patients.

Method used

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  • Implantation body with biological activity of drug controlled-releasing function, its controlled releasing method and preparing method
  • Implantation body with biological activity of drug controlled-releasing function, its controlled releasing method and preparing method
  • Implantation body with biological activity of drug controlled-releasing function, its controlled releasing method and preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0036] Example 1: The effect of oscillating magnetic field on drug release in vitro from blood clot containing superparamagnetic streptomycin PELA microspheres

[0037] 1. Preparation of superparamagnetic chitosan nanospheres

[0038] Preparation of superparamagnetic nano-magnetic chitosan nanoparticles by chemical co-precipitation method: 57.40 g of the mixture of ferrous ammonium sulfate and ferric ammonium sulfate [Fe 2+ / Fe 3+ (mol)=1.2], dissolved in acetic acid solution containing 2% SC (w / v) (pH, 5.5) to prepare liquid A, and transferred to a stirred 500mL three-necked flask; prepare 6mol / L NaOH to form liquid B ; Under nitrogen protection, heat liquid A to 55°C while stirring rapidly. Quickly drop into solution B, and maintain the reaction for 10 minutes; reduce the stirring speed, heat solution A to 85°C, and maintain the reaction for 90 minutes; add an appropriate amount of glutaraldehyde, and maintain the reaction for 30 minutes. Wash with distilled water to remo...

example 2

[0049] Example 2: In vitro drug release by oscillating magnetic field to gelatin microsphere scaffold containing superparamagnetic chitosan hVEGF plasmid

[0050] 1. Preparation of superparamagnetic chitosan nanospheres

[0051] Preparation of superparamagnetic nano-magnetic chitosan nanoparticles by chemical co-precipitation method: the same as Example 1. (slightly)

[0052] 2. Human VEGF 165 -Red fluorescent fusion protein eukaryotic expression plasmid (pDsVEGF 165 Red1-N1) was donated by Dr. Zou Haibo from China-Japan Friendship Hospital.

[0053] 3. Superparamagnetic chitosan pDsVEGF 165 Preparation of Red1-N1 gelatin microspheres

[0054] Preparation of superparamagnetic chitosan pDsVEGF by cross-linking and curing method 165 Red1-N1 plasmid gelatin microspheres:

[0055] 1. Superparamagnetic chitosan (chitosan content about 800mg) 5ml (acetic acid buffer solution pH5.5), heated to 55 ° C, 20% (w / v) concentrated plasmid (pDsVEGF 165 Red1-N1) 8ml was heated to 55°C...

example 3

[0072] Example 3: Effects of different oscillating magnetic field strengths on the in vitro drug release of gelatin microsphere scaffolds containing superparamagnetic chitosan hVEGF plasmids

[0073] Preparation of superparamagnetic chitosan nanospheres, superparamagnetic chitosan pDsVEGF 165 Preparation of Red1-N1 Gelatin Microspheres and Superparamagnetic Chitosan pDsVEGF 165 The preparation of the Red1-N1 plasmid gelatin microsphere scaffold was the same as in Example 2. The arrangement of in vitro dissolution experiment and the intervention method of oscillating magnetic field are adjusted as follows:

[0074] 1. Prepare 4 groups of the same superparamagnetic chitosan pDsVEGF 165 Red1-N1 plasmid gelatin microsphere scaffold, numbered 1, 2, 3, 4. Three pieces in each group were put into a 25ml Erlenmeyer flask, and 20ml of phosphate buffered solution (PBS solution) was added for later use.

[0075] 2. Apply different gradually increasing oscillating magnetic fields to e...

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Abstract

The invention relates to an implant carrying or containing nano level magnet drug-carrying compounds and having medicament controlled biological activity, method for medicament controlled release through the implant, and a process for preparing the implant. Under the action of oscillating magnetic field, the magnetic particles in the implant can move by themselves and / or drive surrounding substance to move, thus achieving the goal of promoting or partially controlling the medicament release in the implant.

Description

technical field [0001] The invention relates to the field of magnetic fields, biopharmaceutical preparations and targeted drug controlled release systems. Specifically related to the pulse drug release system in the drug intelligent delivery system, another pulse magnetic field superimposed in an oscillating magnetic field or a static magnetic field is used. Implement spatial and temporal control over the drug release signal. Background technique [0002] For most drug delivery systems, the drug release of most polymers is diffuse release, so the drug release is affected by many factors and is difficult to control. The pulse drug release system in the drug intelligent delivery system provides a scientific research direction for solving such problems, that is, through environmental influences such as temperature, light, ultrasound, microwave and magnetic field and chemical stimulation signals such as pH and glucose to make the structure and function of the material Changes ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/14A61K47/02A61K47/30A61M31/00
Inventor 罗聪安洪蒋电明杨晓兰张健邹海波朱照静
Owner 罗聪
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