117results about How to "Gentle method" patented technology

The invention provides a preparation method of a supramolecular anti-cancer drug (dicycloplatin). The preparation method comprises the following steps of: adding carboplatin and 1,1-cyclobutanedicarboxylic acid into water according to the mol ratio of 1:1, dissolving and uniformly mixing to obtain the mixed solution, and standing the mixed solution in a dark place at the temperature of more than 0 DEG C and less than or equal to 60 DEG C for 3-9 days, and concentrating under reduced pressure or freeze-drying so as to obtain dicycloplatin. The preparation method disclosed by the invention is moderate in condition and environment friendly; both the yield and the purity of dicycloplatin can be up to nearly 100%; the batch yield can reach 1000g; and thus, the preparation method is particularly applied to industrial production.

This invention discloses a method for preparing metal dielectric composite particles of nanoscale Ag/SiO2. The method comprises: hydrolyzing tetraethyl orthosilicate by NH3 catalysis to prepare SiO2 microspheres, preparing AgClO4 electrolyte solutions with different concentrations, adding the prepared SiO2 microspheres into the AgClO4 electrolyte solutions, ultrasonicating in an electrolytic tank for 10min, inserting two electrodes into the electrolytic tank, applying DC to electrolyze and obtain the product, centrifuging to separate the product, washing with deionized water and ethanol repeatedly, and drying at 30-50 deg.C. This invention utilizes sonoelectrochemical method to deposit Ag nanoparticles onto the surface of SiO2 microspheres. The Ag nanoparticles are uniformly distributed onto the surface of SiO2 colloid, and have excellent potential applications.

The invention relates to a method for preparing an inclusive agent of a polylactic acid or hydroxyapatite composite bone tissue restoring material, which comprises the following steps: getting processed hydroxyapatite by refluxing hydroxyapatite in the alcohol solution with surface modifier as the coupler for 12-48 hours; dissolving polylactic acid macromole monomer with terminal ethenyl and the processed hydroxyapatite in the organic solvent with initiating agent; protecting with nitrogen; extracting after extracting and drying the reactor; separating and purifying no-grafted polylactic acid macromole monomer; extracting the remainder; drying; getting the inclusive agent. The inclusive agent has the wide application, the low cost, the simple method, the mild synthesis condition, the strong utility and the easy industry production, which provides the boundary interaction of the organic or inorganic phase in polylactic acid or hydroxyapatite composite bone tissue restoring material, and improves the ergology property of bone tissue restoring material.

The invention discloses a method for preparing solid (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-tert-butyl acetate and belongs to the pharmaceutical and chemical field. The method includes the following steps that a compound III is dissolved in a mixed solvent of methanol and water, potassium carbonate is added for hydrolysis, potassium carbonate is filtered out and removed, methanol is removed through distillation, an organic solvent is added, and an organic solvent solution of a compound II is obtained after washing; secondly, TEMPO, potassium bromide and sodium bicarbonate are added, stirred, mixed and cooled, then a sodium hypochlorite solution is added dropwise, stirring reaction is carried out, after reaction, a sodium thiosulfate solution is quenched, washed, dried and condensed, and a crude product of a compound I is obtained; thirdly, an organic solvent is added, cooled and stirred after being heated and dissolved and is crystallized and filtered to obtain solid crystal of the compound I. The preparation method is safe, environmentally friendly, easy and convenient to operate, high in yield, high in purify and capable of facilitating large-scale production.

The invention discloses a bifunctional starch-based composite nanoparticle as well as a preparation method and an application thereof. The preparation method comprises the following steps: hydrolyzingstarch to form linear dextrin, and grading the linear dextrin by adopting an alcohol-alcohol gradient precipitation method to obtain linear dextrin with uniform molecular weight distribution; carrying out oxidation treatment on the linear dextrin through an oxidation system to obtain oxidized dextrin; carrying out complexation reaction on the oxidized dextrin and curcumin to form an oxidized dextrin-curcumin complex, so that the oxidized dextrin-curcumin/chitosan hydrochloride composite nanoparticles and chitosan hydrochloride form the oxidized dextrin-curcumin/chitosan hydrochloride composite nanoparticles. According to the method, the aqueous phase solution of the bifunctional starch-based composite nanoparticles containing the gellan is uniformly mixed with the primary emulsion, the obtained double emulsion is subjected to calcium ion induction treatment to obtain the double emulsion gel, and the double emulsion gel has good oxidation resistance and long-term storage stability andcan be applied to the fields of protection of nutritional ingredients, drug delivery, preparation of cosmetics and the like.

A method and electric component, such as inductor, coil, resistor, or the like, are disclosed wherein a winding includes at least one spiral or coiled element, the spiral or coiled element being formed from a piece furnished with cooling ribs.

The invention belongs to the field of proton exchange membrane materials, and particularly relates to a cross-linkable fluorine-containing sulphonated polyarylether compound and a preparation method thereof. The preparation method comprises the following steps: first, performing polycondensation on decafluorobiphenyl, 2,2'-diallylbisphenol A and bisphenol A to prepare a cross-linkable fluorine-containing polyarylether compound; then, enabling the cross-linkable fluorine-containing polyarylether compound to react with a certain amount of sodium 4-hydroxybenzenesulfonate, so that sulphonic groups are introduced into a polymer; finally, preparing to obtain the cross-linkable fluorine-containing sulphonated polyarylether compound. The cross-linkable fluorine-containing sulphonated polyarylether compound can be cast into a membrane by using a solution. The obtained proton exchange membrane has the characteristics of simple preparation process, high heat stability, high oxidation stability,high proton conductivity, good mechanical properties and the like. A cross-linking type proton exchange membrane can be prepared by adding a free radical initiator, so that the solvent resistance is improved.

The invention discloses graphene loaded MOF derivative aerogel and a preparation method thereof. The aerogel is prepared from the following raw material components: graphene oxide, FeCl3. 6H2O, Ni (NO3) 2.6 H2O and phthalic acid, wherein the molar ratio of FeCl3. 6H2O to Ni (NO3) 2.6 H2O to phthalic acid is (1-3): (1-3): (1-3), and the mass ratio of Fe-Ni bimetallic MOF synthesized from FeCl3. 6H2O, Ni (NO3) 2.6 H2O and phthalic acid to graphene oxide is (1: 10)-(10: 1). The invention also provides the preparation method of the aerogel. The preparation method is mild and rapid, controllable incomponents and macroscopic in scale; the key technical problems that components and structures in a graphene/bimetal MOF and derivative composite system thereof are uncontrollable and the like are solved, and the prepared graphene loaded MOF derivative aerogel has wide application prospects in the fields of electro-catalytic energy storage, electromagnetic shielding, adsorption, sensing and the like.

The invention provides a blend of carbon dioxide-propylene oxide copolymers, which comprises 5wt percent to 15wt percent of urethane compounds and 85wt percent to 95wt percent of carbon dioxide-propylene oxide copolymers. The urethane compounds are one kind of materials in compounds shown as from the formula I to the formula VI, wherein n is respectively 2, 4, 6 and 10, and R is methyl, ethide, propyl or butyl. Because molecules of small-molecular urethane compounds contain urethane bonds and/or hydroxide radicals and can be used as proton donors, and the carbon dioxide-propylene oxide copolymers contain carbonyls and can be used as proton acceptors, so the molecules of the urethane compounds can form stronger hydrogen bond effects with the carbon dioxide-propylene oxide copolymers, the compatibility is greatly improved, and further, the fraction elongation rate of the carbon dioxide-propylene oxide copolymers is effectively improved. The invention also provides the preparation method of the blend of the carbon dioxide-propylene oxide copolymers.

The invention provides a preparation method of a fermented traditional Chinese medicine dealcoholic functional beverage. The preparation method comprises the following steps: (a) preparation of seed fungi liquid, red date syrup and fragrant rice fermentation liquor for traditional Chinese medicine fermentation; (b) weighing traditional Chinese medicine recipe of a dealcoholic medicine; (c) fermenting and filtering the dealcoholic medicine traditional Chinese medicine. The traditional Chinese medicine fermented dealcoholic beverage prepared from the method and the preparation method provided by the invention have the advantages that the traditional Chinese medicine fermented dealcoholic beverage can fast alleviate the drunkenness, and the drunkenness can be alleviated within 1-3 hours according to the drinking amount; 2, the beverage can be for alleviating the hangover, and can be used as the body health beverage after the drunkenness; 3, the dealcoholic medicine provided by the invention is free from any chemical additive components, green, safe, and free of toxic and side effect; 4, the raw materials required by the preparation method provided by the invention are low in cost; 5, the traditional Chinese medicine dealcoholic beverage prepared from the method provided by the invention is good in color, flavor and the taste, and attractive for eating; 6, the preparation method provided by the invention is simple in process flow and suitable for industrial production.

The invention discloses a method for extracting pigment from eleochairis toberosa peel. The method comprises the following steps: pretreatment; enzymatic hydrolysis: adding a disodium hydrogen phosphate buffer solution into the eleochairis toberosa peel, adding a compound enzyme in an amount which is 0.4 to 2.0 percent of the mass of the eleochairis toberosa peel, stirring for reacting for 1 to 3 hours at the temperature of 50 to 55 DEG C and at the speed of 700 to 850 rpm, and performing centrifugal filtering; adding the eleochairis toberosa peel undergone the enzymatic hydrolysis into an ethanol solution which is 50 to 70 percent in volume fraction, and performing ultrasonic microwave extraction to obtain a pigment product. The extraction method provided by the invention has a high flavone yield, and original bioactivity can be kept to the maximum extent at the same time; extracted flavone pigment has high stability, and high pigment quality; the method has the characteristics of mildness, high efficiency, easiness, convenience, low energy consumption and the like, has greater advantages when being applied to the field of extraction of natural pigment, and has a wide development prospect.

The invention relates to a coumarin-based light-CO2/N2 double stimuli-responsive surfactant, and belongs to the field of colloid and interface chemistry. The coumarin-based light-CO2/N2 double stimuli-responsive surfactant is a coumarin-based bicarbonate surfactant. According to the preparation method, the coumarin-based bicarbonate surfactant is obtained by taking a dibromo alkane and 7-hydroxycoumarin as raw materials via O alkylation, ammoniation, and adding of carbon dioxide. The coumarin-based light-CO2/N2 double stimuli-responsive surfactant possesses excellent surfactant performance, is responsive to ultraviolet light, visible light, CO2, and N2, and possesses double stimulative responsiveness.

The invention relates to preparation methods for preparing aromatic amide compounds and particularly relates to an aromatic-ring C-H bond direct-amination reaction method of aromatic amides. The method provided by the invention has the characteristics of simplicity, convenience, high efficiency and the like and easily achieves the large-scale preparation of a compound represented by a formula 3 shown in the description. According to the method provided by the invention, a compound represented by a formula 1 shown in the description and a compound represented by a formula 2 shown in the description serve as raw materials, cheap divalent copper serves as a catalyst, oxygen in air serves as an oxidant, and an aromatic-ring C-H bond direct-amination reaction of the aromatic amides is achieved in a high-yield manner. According to the method provided by the invention, the defects of the general preparation of aromatic amides that a reaction substrate is required to be functionalized, a process is relatively tedious and the like are overcome, and the defects of high cost and difficulty in large-scale preparation caused by the additional adding of expensive oxidants such as Ag are also avoided. The method has the characteristics of simplicity, moderateness, relatively good functional group compatibility and the like and has a very good application value.

The invention discloses a method for controllably synthesizing Ag2Se nano crystal. The method comprises the following steps of: obtaining low-valence Se in processes of simulating glutathione reductase in an organism outside cells and reducing sodium selenite (Na2SeO3) by using coenzyme, reacting the low-valence Se and Ag<+> coordinated with alanine in an inert atmosphere, and thus obtaining the Ag2Se nano crystal with good monodispersity, uniform particle size and different fluorescence emission wavelengths under the condition of aqueous phase. In the method, the size and the fluorescence emission wavelength of the product are controlled by controlling the ratio of the Se precursor to the Ag precursor. The method is easy and convenient, can be repeated for preparation, does not require inflammable, explosive and toxic metallic organic compounds, is good in safety, and can be applied in the fields of chemistry and material science more widely.

This invention relates to a separation and purification method for sponge dry cells-original cells, which utilizes four methods of differential centrifugation, specific agglutination of cells, differential adherence and centrifugation of density and grads together to increase the purity and efficiency of separation and purification of sponge original cells and provides an effective method for studying the biological property of exuberate film sponge dry cells and the vitro culture rule.

The invention discloses a liposuction device for autologous fat transplantation of the human body and a usage method thereof and belongs to the field of medical surgical operation devices. A fat quantification device and a fat storage device are arranged in an incubator, and a temperature sensor I and a temperature sensor II are arranged in a liposuction end head and the incubator respectively. A pressure pump switch for starting a pressure pump or not through controlling, a pressure display screen and a pressure regulating knob are all arranged on the pressure pump. A thin water body impact tube is arranged on a delivery pipeline between the fat quantification device and the fat storage device. A primary filter layer and a secondary filter layer are sequentially arranged in the fat storage device from top to bottom. A more suitable storage environment can be provided for fat cells, and keeping of the activity of the fat cells is promoted. Misoperations produced by excessive and easily mistaken switching and the situation that normal operation cannot be performed in time can be prevented. The keeping of the survival rate of the fat cells is promoted. The accuracy of fat quantification can be ensured, and collection and reutilization of the fat cells and residual materials are promoted.