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Method of preparing compound osseous tissue renovating material interconsistency agent of polylactic acid/hydroxyapatite

A technology of hydroxyapatite and repair materials, applied in medical science, prosthesis, etc., can solve the problems of poor compatibility between natural polymer materials and hydroxyapatite, and low mechanical properties of composite materials, so as to facilitate industrial production and improve mechanical properties. Effect of improving mechanical properties and bending strength

Inactive Publication Date: 2008-02-27
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the compatibility between natural polymer materials and hydroxyapatite is relatively poor, and the mechanical properties of composite materials are not high.

Method used

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  • Method of preparing compound osseous tissue renovating material interconsistency agent of polylactic acid/hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Using vinyltrimethoxysilane as a coupling agent to treat hydroxyapatite.

[0021] Reflux 10g of micron-sized hydroxyapatite in 0.1g of vinyltrimethoxysilane in 10ml of 80% ethanol solution for 40 hours, and use Fourier transform infrared spectroscopy to detect the treated hydroxyapatite surface. The Fourier transform infrared spectrum is shown in Figure 1 As shown, 3000cm -1 The stretching vibration peaks of C-H appear on the left and right, and it is confirmed by Fourier transform infrared spectroscopy that vinyltrimethoxysilane containing ethylene double bonds that can react with free radicals has been introduced on the surface of hydroxyapatite.

Embodiment 2

[0022] Example 2: Treating hydroxyapatite with γ-methacryloxypropyltriethoxysilane and vinyltrimethoxysilane as coupling agents.

[0023] Reflux 10g micron-sized hydroxyapatite in 10ml 50% ethanol solution of 0.5g γ-methacryloxypropyltriethoxysilane and 0.5g vinyltrimethoxysilane for 12 hours, and use Fourier transform infrared spectroscopy Detect the treated hydroxyapatite surface, the Fourier transform infrared spectrum is shown in Figure 1, 3000cm -1 The stretching vibration peaks of C-H appear on the left and right, and it is confirmed by Fourier transform infrared spectroscopy that γ-methacryloxypropyltriethoxysilane containing ethylene double bonds that can react with free radicals has been introduced on the surface of hydroxyapatite.

Embodiment 3

[0024] Example 3: Treatment of hydroxyapatite with isopropyl bis(diethylene glycol oleate)aluminate.

[0025] 10g of nano-sized hydroxyapatite was refluxed in 10ml of 10% ethanol solution of 0.3g bis(diethylene glycol oleate)aluminate in 10% ethanol solution for 24 hours, and the processed hydroxyapatite was detected by Fourier transform infrared spectroscopy Surface, Fourier Transform Infrared Spectrum is similar to Figure 1, at 3000cm -1 The stretching vibration peak of carbon and hydrogen appeared around the wave number, and it was confirmed by Fourier transform infrared spectroscopy that the free radical-reactable bis(diethylene glycol oleate)aluminate isopropyl aluminate containing ethylene double bonds has been introduced on the surface of hydroxyapatite. ester.

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Abstract

The invention relates to a method for preparing an inclusive agent of a polylactic acid or hydroxyapatite composite bone tissue restoring material, which comprises the following steps: getting processed hydroxyapatite by refluxing hydroxyapatite in the alcohol solution with surface modifier as the coupler for 12-48 hours; dissolving polylactic acid macromole monomer with terminal ethenyl and the processed hydroxyapatite in the organic solvent with initiating agent; protecting with nitrogen; extracting after extracting and drying the reactor; separating and purifying no-grafted polylactic acid macromole monomer; extracting the remainder; drying; getting the inclusive agent. The inclusive agent has the wide application, the low cost, the simple method, the mild synthesis condition, the strong utility and the easy industry production, which provides the boundary interaction of the organic or inorganic phase in polylactic acid or hydroxyapatite composite bone tissue restoring material, and improves the ergology property of bone tissue restoring material.

Description

technical field [0001] The invention relates to a preparation method of a compatibilizer for polylactic acid / hydroxyapatite composite bone tissue repair material. Background technique [0002] Bone trauma is a common disease in clinical surgery. In my country, there are more than 10 million patients with bone injuries, spinal fusion, and bone cysts caused by various reasons every year, and about 500,000 of them need to use bone repair materials. With the aging of the population structure, the development of transportation and manufacturing, and the increasing environmental pollution, this number is still rising. Lesions and injuries of bone tissue directly affect people's quality of life, so the repair of bone tissue damage has always been a medical research topic that people have paid close attention to. Implantation of artificial materials into the body to repair or replace diseased and damaged bone tissue is the main clinical treatment method. [0003] The implants used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/18A61L27/12
Inventor 张秀菊林志丹周长忍
Owner JINAN UNIVERSITY
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