Preparation method of supramolecular anti-cancer drug (dicycloplatin)

Abstract

The invention provides a preparation method of a supramolecular anti-cancer drug (dicycloplatin). The preparation method comprises the following steps of: adding carboplatin and 1,1-cyclobutanedicarboxylic acid into water according to the mol ratio of 1:1, dissolving and uniformly mixing to obtain the mixed solution, and standing the mixed solution in a dark place at the temperature of more than 0 DEG C and less than or equal to 60 DEG C for 3-9 days, and concentrating under reduced pressure or freeze-drying so as to obtain dicycloplatin. The preparation method disclosed by the invention is moderate in condition and environment friendly; both the yield and the purity of dicycloplatin can be up to nearly 100%; the batch yield can reach 1000g; and thus, the preparation method is particularly applied to industrial production.

Description

technical field

[0001] The invention relates to the field of medicine preparation, and more particularly relates to a preparation method of supramolecular anticancer drug bicycloplatinum. Background technique

[0002] In 1969, Barnett Rosenberg discovered cisplatin (cis-[PtC 1 2 (NH 3 ) 2 ]) have anticancer activity. In 1978, cisplatin was approved by the FDA as an anticancer drug and was launched in the United States, and it has been used to treat various human cancers for decades. During the course of treatment, it was found that cisplatin is a highly toxic drug with severe nausea and vomiting, gastrointestinal toxicity, strong nephrotoxicity, bone marrow suppression, ototoxicity, peripheral neurotoxicity, etc. (Barabas K, Milner R, Lurie D , Adin C. Cisplatin: a review of toxicities and therapeutic applications. Vet Comp Oncol, 2008, 6:1-18). In order to overcome the shortcoming of high toxicity of cisplatin, the work of modifying the structure of cisplatin to discov...

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