201results about How to "Mild preparation method" patented technology

The invention belongs to the field of biomedical engineering materials and discloses a nitric oxide loaded cationic polymer, a preparation method therefor and an application of the nitric oxide loaded cationic polymer in the field of biomedicine. A cationic polymer which is used for loading nitric oxide and containing a dendritic polyamide element specifically is a polyethyleneimine grafted dendritic polyamide polymer and has a molecular formula shown in the description. The invention further provides the nitric oxide loaded cationic polymer based on the polymer. The nitric oxide loaded cationic polymer disclosed by the invention can be applied to the field of biomedicine as a nitric oxide donor material through loading NO, is used as a biomedical material and particularly is applied to the preparation of antibacterials; and the nitric oxide loaded cationic polymer has the effects of effectively inhibiting the growth and reproduction of bacteria and fungi, has remarkable inhibitory effects on common oral cavity pathogenic bacteria, dermatophyte, wound infection bacteria and the like, has the functions of promoting wound healing, diminishing inflammation and the like and provides a support for the application of the nitric oxide loaded cationic polymer in preparation of the biomedical engineering materials.

The invention provides a preparation method of a supramolecular anti-cancer drug (dicycloplatin). The preparation method comprises the following steps of: adding carboplatin and 1,1-cyclobutanedicarboxylic acid into water according to the mol ratio of 1:1, dissolving and uniformly mixing to obtain the mixed solution, and standing the mixed solution in a dark place at the temperature of more than 0 DEG C and less than or equal to 60 DEG C for 3-9 days, and concentrating under reduced pressure or freeze-drying so as to obtain dicycloplatin. The preparation method disclosed by the invention is moderate in condition and environment friendly; both the yield and the purity of dicycloplatin can be up to nearly 100%; the batch yield can reach 1000g; and thus, the preparation method is particularly applied to industrial production.

The invention relates to a sponge composite metallic organic framework material for adsorption separation and belongs to the technical field of materials. According to the invention, a two-step in-situ growth method is adopted for loading MOFs (metallic organic framework material) into a duct in a sponge carrier. The MOFs is synthesized from following organic ligands and metal salts, wherein the organic ligands include pyrazine, trimesic acid, terephthalic acid, 2,5-dihydroxyterephthalic acid, and the metal salts include cupric fluosilicate, magnesium nitrate, zirconium chloride, cupric nitrate, chromic nitrate, ferric nitrate, aluminum nitrate and hydrates thereof. According to a preparation method provided by the invention, a large amount of MOFs loaded in the duct in the sponge carriercan be realized; MOFs load rate is high; load is stable; the defects of fragility and easiness in loss of MOFs powder can be overcome; a breakthrough experiment proves that the material provided by the invention has the characteristics of high CO2-absorbing capacity, high adsorption separation selectivity, stable adsorption separation property, and the like.

The invention discloses polymer and liquid crystal composition and liquid crystal handwriting display device using the same. The polymer and liquid crystal composition comprises a polymer and a liquid crystal which are mutually soluble, wherein the polymer comprises 30-70 parts of an oligomer monomer, 0.5-3 parts of a photoinitiator, 30-70 parts of an oligomer, 0.1-1 part of an adhesion promoter and 5-50 parts of a diluent. The invention further discloses a preparation method of the liquid crystal handwriting display device. The liquid crystal handwriting display device adopting the polymer and the bi-stable cholesteric liquid crystal has high display contrast, low driving voltage and sensitivity in handwriting, furthermore, electricity is not consumed in a handwriting displaying process and is only consumed at a refresh moment, handwriting refresh can be performed for millions of times, and the handwriting display device is environment-friendly.

The invention discloses a preparation method of a PVDF (polyvinylidene fluoride) film modified by silver phosphate modified nano negative ion powder. The preparation method comprises the steps of firstly, obtaining nano silver phosphate by adopting an ion exchange method, and modifying negative ion powder by nano silver phosphate to obtain negative ion powder with different silver carrying capacity; secondly, adding a proper amount of the silver-carrying negative ion powder into a PVDF casting film solution, and preparing the modified PVDF film containing the silver-carrying negative ion powder by adopting a phase inversion method. By virtue of peculiar nanometer size effect and surface energy of the silver-carrying negative ion powder, the PVDF film is endowed with effective anti-biological-pollution capability, the hydrophilicity of the PVDF film is improved, and the flux recovery rate of the PVDF film is increased; in addition, the preparation method of the modified PVDF film is simple and easy to adjust and control.

The invention belongs to the technical field of a new energy source material, and particularly relates to a preparation method of a zinc sulfide and graphene oxide compound and application of the compound to a lithium-sulfur battery positive electrode material. The preparation method is concretely characterized in that carbon disulfide and quadrol solution are stirred and mixed to obtain a mixed solution; oxidized graphene is added into a solvent to be subjected to ultrasonic treatment, and is then added into the mixed solution to obtain mixed liquid; a zinc nitrate solution is dropwise addedinto the mixed liquid; after the dropwise addition is completed, the mixed liquid is transferred into a kettle; reaction, cooling, centrifugal separation, washing and drying are performed; the compound material is obtained. Excessive metal sulfide ZnS is used as chemical adsorption and catalytic active sites of multi-sulfur ions; graphene oxide is a conductive substrate, so that the electroconductibility of the composite material is improved; the transfer and transmission of electrons on the ZnS and multi-sulfur ion interface are accelerated. Through chemical reaction sulfur carrying, the energy consumption is reduced; the active substance dispersion is uniform. The great sulfur carrying quantity reaching up to 90 percent is realized, so that the energy density of the battery is greatly improved.

The invention discloses a Mo-Se-Ta+TiAlTaN soft and hard composite coated tool and a manufacturing method thereof. The coated tool comprises a tool matrix material which is high-speed steel or hard alloy; and a Ti+TiN transition layer, a TiAlTaN hard coating, a Zr transition layer and a Mo-Se-Ta soft coating are sequentially arranged from a tool matrix to a surface coating. The manufacturing method for the coated tool adopts a multi-arc ion plating and medium-frequency magnetron sputtering mode, and comprises the steps of depositing the Ti+TiN transition layer, depositing the TiAlTaN hard coating, depositing the Zr transition layer and depositing the Mo-Se-Ta soft coating. The coated tool disclosed by the invention has relatively high hardness, has very good lubricating performance and a low friction coefficient, has very good thermal stability, oxidization resistance, corrosion resistance and abrasion resistance, and has a wide application prospect; and the preparation method is simple and is easy to operate.

The invention relates to a sulfonic acid functionalized polystyrene high-fluorescence microsphere and a preparation method thereof. According to the invention, a cross-linking agent used for preparingthe microsphere is a 1,7-vinyl-perylene bisimide derivative, and the imide site of the cross-linking agent has a large-volume substituent group, so the molecule of the cross-linking agent is not easyto aggregate and is thus prevented from the phenomenon of self-polymerization. Meanwhile, the 1,7-vinyl-perylene bisimide derivative has a fluorescent chromophoric group; due to the fact that aggregation is limited by the large-volume substituent group and movement of the 1,7-vinyl-perylene bisimide derivative is limited by a cross-linking structure in the microsphere, fluorescence quenching caused by molecule aggregation is avoided, and the microsphere eventually has high fluorescence performance. The method successfully solves the problem that gel type polystyrene ion exchange resin is prone to poisoning, overcomes the phenomenon of high probability of self-polymerization of divinylbenzene when the gel type polystyrene ion exchange resin is prepared in the prior art, and enables the microsphere to have high fluorescence property.

The invention discloses a glutathione response-type dual-drug carrier as well as a preparation method and application thereof, and belongs to the field of biomedical engineering materials. The preparation method comprise the following steps: performing Michael addition reaction to obtain hyperbranched poly(amide amine)s; then connecting a hydrophobic drug onto an end group amino of a high polymer by amidation reaction, so as to form a prodrug micelle molecule; then loading another hydrophobic drug by subject-object assembly of the prodrug micelle molecule, thus effectively increasing drug loading capacity and promoting an synergistic effect of the drugs; preparing to obtain the glutathione response-type dual-drug carrier. The method is mile, the operation is convenient, byproducts are fewer, and a product is easy to separate and purify, thus facilitating the material biocompatibility. The glutathione response-type dual-drug carrier has the advantages of simple material components, easy-to-get raw materials and good biocompatibility, and is hopefully widely applied to the field of the biomedical engineering materials as a great amount of surface functional groups capable of being modified provide support for the application of the carrier in preparing the biomedical engineering materials.

The invention discloses an NNN ligand, metal complexes thereof, preparation methods and application, and particularly provides an NNN ligand 1, a metal complex 2 of the NNN ligand, a metal complex 3 of the NNN ligand and preparation methods of the NNN ligand 1 and the metal complexes, as well as application of the metal complex 3 of the NNN ligand to catalysis on hydroboration reaction of bis-substituted olefin, especially application of the metal complex 3 to catalysis on asymmetric hydroboration reaction of 1, 1-bis-substituted olefin. The metal complex 3 of the NNN ligand has good catalytic activity in the hydroboration reaction of the bis-substituted olefin, especially asymmetric hydroboration reaction of the 1, 1-bis-substituted olefin, has excellent regioselectivity and enantioselectivity, and is high in yield and mild in reaction conditions; besides, the preparation methods of the NNN ligand and the metal complexes thereof are simple, environment-friendly, mild in reaction conditions, relatively high in yield, and simple in post-processing, and the raw materials are low in cost and easy to obtain, so that the preparation methods are suitable for industrial production. (The formulas of the NNN ligand 1, metal complex 2 and metal complex 3 are shown in the description).

The invention relates to a graphene and ferroferric oxide @gold composite, and a preparation method and an application of the graphene and ferroferric oxide @gold composite. The preparation method of the graphene and ferroferric oxide @gold composite comprises the following steps: a ferroferric oxide @gold complex modified by azide mercaptan is constructed, oxidized graphene is activated by thionyl chloride and then reacts with propargyl alcohol to produce alkynylation oxidized graphene, and then the ferroferric oxide @gold complex and the alkynylation oxidized graphene are catalyzed in a nitrogen atmosphere and alkynyl groups and and azide groups undergo click reaction, thereby obtaining the graphene and ferroferric oxide @gold composite. Reaction conditions of the preparation method of the graphene and ferroferric oxide @gold composite are mild and the preparation method is simple and reliable. The graphene and ferroferric oxide @gold composite allows a system to be stable through covalent bond connection, has the characteristics of magnetism, good microwave absorption performance, good plasma resonance absorption and attenuation to X-rays, and can be applied to nuclear magnetic imaging, microwave-induced thermoacoustic tomography, photoacoustic tomography and X-ray imaging.

The invention discloses a preparation method for graphene. According to the method, the graphene is obtained by reduction and oxidization by adopting a food antioxidant. The preparation method is green, safe, mild and simple in the preparation process; and the obtained grapheme is high in quality and benefits mass preparation. The graphene prepared by the method has potential application value in aspects of separation, enriching, a composite material based on the grapheme and the like.

The invention discloses application of a water-soluble fluorescent carbon dot in detection of heavy metal silver ion content. The method comprises the following steps: taking a 2mu L synthetic carbon dot stock solution, diluting to 2mL with a BR buffer solution to be taken as a fluorescent probe, exciting with 352nm wavelength light, determining fluorescence intensity of the fluorescent carbon dot probe at 441nm wavelength and recording as I0; taking an another fluorescent carbon dot probe, respectively adding different concentrations of silver ion solutions, repeating the determination step, recording as I441, and calculating linear relation between variation of the fluorescence intensity of the fluorescent carbon dot probe before and after the silver ions are added and the silver ion concentration according to the variation of the fluorescence intensity; and adding a to-be-detected sample into the fluorescent carbon dot probe, recording the variation of the fluorescence intensity at the 441nm wavelength, and calculating the mass or concentration of the added silver ions according to the linear relation. The method disclosed by the invention has an accurate heavy metal silver ion detection result, is convenient and efficient, and has good market prospects.

The invention belongs to the field of defect control, and relates to a simple, moderate and accurate preparation method for a transition-metal sulfide nanosheet sulfur vacancy of a transition-metal sulfide sulfur vacancy. The preparation method comprises the following steps of: transferring a prepared transition-meta sulfide nanosheet to a substrate which can be firmly combined with the prepared transition-metal sulfide nanosheet, placing in a prepared weak oxidizing solution and soaking, then washing off the residual solution by using DI water, and drying by using a hot plate. Through using matching of electronic induction of weak oxidizing ions and formation energy of the transition-metal sulfide sulfur vacancy, construction of the sulfur vacancy can be accurately realized without introducing other types of defects. In addition, compared with a traditional physical defect control strategy, the method cannot cause wrinkle and damage of a local material. The sulfur vacancy in a transition-metal sulfide can be controlled in a large area. At the same time, the method is also compatible with a traditional CMOS technology. So, the method has great significance for exploring characteristic control of the sulfur vacancy in the transition-metal sulfide and promoting application of defect engineering.

The invention relates to the technical field of organic synthesis, in particular to a solid acid catalyst as well as a preparation method thereof and a preparation method of hydroxy phenylglycine. Theinvention provides the preparation method of the solid acid catalyst; the preparation method comprises the following steps that ludox, aluminum hydroxide and inorganic strong alkali are subjected tohydrothermal synthesis reaction, so that a hydrothermal synthesis product system is obtained; the hydrothermal synthesis product system and ammonium nitrate solution are subjected to ionic exchange reaction, so that a solid acid catalyst precursor is obtained; and the solid acid catalyst is roasted, so that the solid acid catalyst is obtained. The solid acid catalyst provided by the invention is used for preparing hydroxy phenylglycine, the yield of hydroxy phenylglycine is as high as 75.2%, the product purity reaches up to 99.3%, and the activated solid acid catalyst has an excellent catalytic effect after being recycled for ten times. The solid acid catalyst provided by the invention has high acidity, high catalytic efficiency and high recycling rate, meanwhile, the preparation method issimple, no template is used, and the solid acid catalyst is environmentally friendly.

The invention relates to a flower-ball-shaped covalent organic framework material as well as preparation and application thereof. Tris (4-aminophenyl) amine and 1, 3, 5-tris (4-formylphenyl) benzene are used as monomers, and the covalent organic framework material with high crystallinity and a flower-ball-shaped structure formed by stacking nanosheets is prepared through a reaction at room temperature. When the flower-ball-shaped covalent organic framework material is used as a solid-phase extraction adsorbent, separation and enrichment of quinolone antibiotics can be realized, the recycling performance is good, and the use cost is greatly reduced. By combining a high performance liquid chromatography tandem mass spectrometer, a detection method for trace quinolone antibiotics in complex samples such as environmental water and food is formed, and the accuracy and reproducibility are high, and the detection limit is low.

The invention belongs to the field of biomedical engineering materials, and particularly relates to dendritic molecule-modified fluorescent quantum dots, and a preparation method and an application thereof. The preparation method comprises the following steps of (1) dissolving the dendritic molecule and 3-mercaptopropyl trimethyl siloxane in dimethyl sulfoxide, adding an initiator, introducing the gas to expel oxygen, carrying out a sealed reaction, precipitating, filtering, washing, and drying to obtain the dendritic molecule with siloxane terminals; and (2) dissolving the dendritic molecule with the siloxane terminals obtained by the step (1) and water-soluble quantum dots in water, loading the solution in a dialysis bag, putting the dialysis bag in a solution, immersing the dialysis bag with stirring, then immersing in water, and freeze-drying to obtain the dendritic molecule-modified fluorescent quantum dots. The preparation method is mild, convenient for operations and little in by-products. Besides, the dendritic molecule-modified fluorescent quantum dots can be separated and purified easily, and have good biocompatibility. A great amount of modifiable functional groups on the surfaces of the quantum dots can provide supports for the application of the quantum dots in preparing the biomedical engineering materials.

The invention relates to a preparation method of structure-controllable CdS nanometer materials. According to the method, Cd(Ac) 2H2O and R1NHCSNHR2 are used as reactants; DETA and DIW two-ingredient solution in different proportion ratio are used as a growth solvent system; solvent heat reaction is performed to obtain the CdS nanometer material with different appearances. The preparation method provided by the invention is mild; the operation is simple and convenient; the success rate is high; the repeatability is high; the product purity is high; the mass preparation can be realized. The novel structure CdS nanometer materials grow through the DETA and DIW two-ingredient solution; the flower-shaped, line-shaped and tree-shaped structures are respectively realized; in addition, the CdS nanometer materials have strong optical catalysis activity, and can be applied to catalytic degradation of organic pollutants.

The invention provides a millimeter-level flow control technology-based water-soluble core blast bead preparing method. The millimeter-level flow control technology-based water-soluble core blast beadpreparing method comprise preparing water-in-oil-in-water (W/O/W) emulsion drops through a three-dimensional confocal channel, wherein the internal phase of the drops is water soluble core solution,the intermediate phase of the drops is uncured wall material precursor, and the external phase of the drops are aqueous solution containing surfactant; performing wall material curing and blast bead encapsulation in a photocuring manner. The millimeter-level flow control technology-based water-soluble core blast bead preparing method is simple in applied equipment, low in production cost and highin encapsulation efficiency and can prepare millimeter-level water-soluble core blast beads uniform in size and diameter and controllable in capsule wall thickness.