The invention belongs to the field of
biomedical engineering materials, and particularly relates to dendritic molecule-modified fluorescent
quantum dots, and a preparation method and an application thereof. The preparation method comprises the following steps of (1) dissolving the dendritic molecule and 3-mercaptopropyl trimethyl
siloxane in
dimethyl sulfoxide, adding an initiator, introducing the gas to expel
oxygen, carrying out a sealed reaction, precipitating, filtering, washing, and
drying to obtain the dendritic molecule with
siloxane terminals; and (2) dissolving the dendritic molecule with the
siloxane terminals obtained by the step (1) and water-soluble
quantum dots in water, loading the solution in a
dialysis bag, putting the
dialysis bag in a solution, immersing the
dialysis bag with stirring, then immersing in water, and freeze-
drying to obtain the dendritic molecule-modified fluorescent
quantum dots. The preparation method is mild, convenient for operations and little in by-products. Besides, the dendritic molecule-modified fluorescent quantum dots can be separated and purified easily, and have good
biocompatibility. A great amount of modifiable functional groups on the surfaces of the quantum dots can provide supports for the application of the quantum dots in preparing the
biomedical engineering materials.