Polydopamine modified molybdenum disulfide composite silver nanoparticle antibacterial agent and preparation method thereof

A technology of silver nanoparticles and molybdenum disulfide, which is applied in the direction of antibacterial drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easy agglomeration, surface defects and unfavorable biological functionalization, etc. Achieve the effect of uniform dispersion, uniform size and regular shape

Active Publication Date: 2018-09-04
元朗生命科技(南京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, molybdenum disulfide is prone to agglomeration in physiological environments, and the few surface defects are not conducive to biofunctionalization.

Method used

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  • Polydopamine modified molybdenum disulfide composite silver nanoparticle antibacterial agent and preparation method thereof
  • Polydopamine modified molybdenum disulfide composite silver nanoparticle antibacterial agent and preparation method thereof
  • Polydopamine modified molybdenum disulfide composite silver nanoparticle antibacterial agent and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Mix 0.8mL 10mg / mL silver nitrate solution, 5mL 150μg / mL molybdenum disulfide@polydopamine (MoS 2 @PDA) The nanosheet solution was added to a 50mL jar containing 90μL ammonia solution, and magnetically stirred for 30 min. Then 9.3 mL of 10 mg / mL glucose solution was added, and the magnetic stirring reaction was continued for 1.5 h. Wash with ultrapure water several times, centrifuge at 12,000 rpm, and centrifuge for 40 minutes, and disperse the final product in ultrapure water to obtain polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent. figure 1 The polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent has regular shape and uniform dispersion, and the size of the silver nanoparticle is about 5-6nm. from figure 2 It can be seen that the thickness of the prepared polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent is about 10 nm. Under this conditi...

Embodiment 2

[0039] Mix 0.8mL 10mg / mL silver nitrate solution, 5mL 150μg / mL molybdenum disulfide@polydopamine (MoS 2 @PDA) The nanosheet solution was added to a glass vessel containing 180 μL ammonia solution and stirred magnetically for 20 min. Then 9.3 mL of 10 mg / mL glucose solution was added, and the magnetic stirring reaction was continued for 1 h. Wash with ultrapure water several times, centrifuge at 12,000 rpm, and centrifuge for 20 minutes, and disperse the final product in ultrapure water to obtain polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent. image 3 The polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent has regular morphology, dense distribution of silver nanoparticles, and a size of about 5-6nm. Under this condition, the molar ratio of ammonia water to silver nitrate is 100:1, and the molar ratio of silver nitrate to molybdenum disulfide is 10:1.

Embodiment 3

[0041] Mix 0.8mL of 10mg / mL silver nitrate solution, 5mL of 150μg / mL molybdenum disulfide@polydopamine (MoS 2@PDA) The nanosheet solution was added to a glass vessel containing 180 μL of ammonia solution and stirred magnetically for 20 min. Then add 9.3mL of 10mg / mL glucose solution, and react in microwave at 60°C for 10min. Washing with ultrapure water several times, the centrifugation speed is 12000rpm, and the centrifugation time is 20min, and the final product is dispersed in ultrapure water to obtain polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent. Figure 4 The polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent has regular morphology, dense distribution of silver nanoparticles, and a size of about 5-6nm. Under this condition, the molar ratio of ammonia water to silver nitrate is 100:1, and the molar ratio of silver nitrate to molybdenum disulfide is 10:1.

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Abstract

The invention discloses a preparation method of a polydopamine modified molybdenum disulfide composite silver nanoparticle antibacterial agent. The method comprises the steps of: preparing a molybdenum disulfide@polydopamine nanosheet solution; preparing a silver nitrate solution and weighing ammonia water, with the ammonia water and the silver nitrate solution being in a molar ratio of 50-100:1,and the silver nitrate and molybdenum disulfide being in a molar ratio of 1-50:1; preparing a glucose solution, with the glucose and silver nitrate being in a molar ratio of 10:1; adding the solutionprepared in the previous two steps and ammonia water into a wild-mouth bottle, conducting magnetic stirring for 20min-30min, then adding a glucose solution, performing magnetic stirring for 1h-1.5h orcarrying out microwave reaction at 60DEG C for 10min for reduction; cleaning the product with ultrapure water, conducting centrifugal purification, dispersing the final product in ultrapure water, and performing storage in a refrigerator at 4DEG C. The preparation method is simple and efficient, has good reproducibility, is convenient for mass production, and meets the requirements of environmental friendliness. The polydopamine modified molybdenum disulfide composite silver nanoparticle antibacterial agent prepared by the method has the advantages of regular morphology, uniform particle size, homogeneous dispersion, reduced cost and excellent antibacterial effect.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial synthesis, and more specifically relates to a novel polydopamine-modified molybdenum disulfide composite silver nanoparticle antibacterial agent and a preparation method thereof. Background technique [0002] Bacterial infection has always been a serious threat to human health, and the increasing drug resistance of bacteria has made bacterial infection more difficult to deal with. Studies have shown that bacterial biofilm is one of the important mechanisms for the formation of bacterial drug resistance, and is the main reason for the recurrent and difficult control of many chronic infectious diseases. Antibiotics represented by penicillin have always been the main treatment for bacterial infectious diseases. Traditional antimicrobial therapy relies on antibiotics to kill or interfere with bacterial growth, and its use is limited by toxicity and allergic responses to host cells. Furthermore,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K47/02A61K47/34A61K9/16A61P31/04
CPCA61K9/1611A61K9/1641A61K33/38A61P31/04
Inventor 汪联辉宇文力辉孙一婷翁丽星
Owner 元朗生命科技(南京)有限公司
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