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Nitric oxide loaded cationic polymer, preparation method therefor and application of nitric oxide loaded cationic polymer

A cationic polymer, nitric oxide technology, applied in the field of biomedical engineering materials

Active Publication Date: 2016-10-26
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the synthesis of nitric oxide donor materials grafted with highly branched polyethylenimine with good biocompatibility dendritic polyamide by click chemistry method and its application in the field of antibacterial have not been reported.

Method used

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  • Nitric oxide loaded cationic polymer, preparation method therefor and application of nitric oxide loaded cationic polymer
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  • Nitric oxide loaded cationic polymer, preparation method therefor and application of nitric oxide loaded cationic polymer

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Embodiment 1

[0091] Embodiment 1: the synthesis of azide polyethyleneimine

[0092] Dissolve azidoacetic acid in pure water, add hyperbranched polyethyleneimine aqueous solution under ice bath, add N-hydroxysuccinimide (NHS) to stabilize it for 20 minutes, measure pH: 2, add 1-ethyl-(3 -Dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) was reacted for 15 hours, dialyzed and freeze-dried to obtain azide-modified dendrimer polyethyleneimine (PEI-N 3 ).

[0093] The concentration of the polyethyleneimine aqueous solution is 20wt%; the weight average molecular weight of the PEI is 1800; the azidoacetic acid, polyethyleneimine, N-hydroxysuccinimide (NHS), 1-ethyl-( The molar ratio of 3-dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) is 10:1:1:1.

Embodiment 2

[0094] Embodiment 2: the synthesis of azide polyethyleneimine

[0095] Dissolve azidoacetic acid in pure water, add hyperbranched polyethyleneimine aqueous solution under ice bath, add N-hydroxysuccinimide (NHS) to stabilize for 30 minutes, measure pH: 3, add 1-ethyl-(3 -Dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) was reacted for 18h, dialyzed and freeze-dried to obtain azide-modified dendritic polyethyleneimine (PEI-N 3 ).

[0096] The concentration of the polyethyleneimine aqueous solution is 30wt%; the weight average molecular weight of the PEI is 2000; the azidoacetic acid, polyethyleneimine, N-hydroxysuccinimide (NHS), 1-ethyl-( The molar ratio of 3-dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) is 11:1:1:1.

Embodiment 3

[0097] Embodiment 3: the synthesis of azide polyethyleneimine

[0098]Dissolve azidoacetic acid in pure water, add hyperbranched polyethyleneimine aqueous solution under ice-cooling, add N-hydroxysuccinimide (NHS) to stabilize for 40 minutes, measure pH: 5, add 1-ethyl-(3 -Dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) was reacted for 20h, dialyzed and freeze-dried to obtain azide-modified dendrimer polyethyleneimine (PEI-N 3 )

[0099] The concentration of the polyethyleneimine aqueous solution is 50wt%; the weight average molecular weight of the PEI is 2500; the azidoacetic acid, polyethyleneimine, N-hydroxysuccinimide (NHS), 1-ethyl-( The molar ratio of 3-dimethylaminopropyl) carbodiimide hydrochloride (EDC·HCl) is 12:1:1:1.

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Abstract

The invention belongs to the field of biomedical engineering materials and discloses a nitric oxide loaded cationic polymer, a preparation method therefor and an application of the nitric oxide loaded cationic polymer in the field of biomedicine. A cationic polymer which is used for loading nitric oxide and containing a dendritic polyamide element specifically is a polyethyleneimine grafted dendritic polyamide polymer and has a molecular formula shown in the description. The invention further provides the nitric oxide loaded cationic polymer based on the polymer. The nitric oxide loaded cationic polymer disclosed by the invention can be applied to the field of biomedicine as a nitric oxide donor material through loading NO, is used as a biomedical material and particularly is applied to the preparation of antibacterials; and the nitric oxide loaded cationic polymer has the effects of effectively inhibiting the growth and reproduction of bacteria and fungi, has remarkable inhibitory effects on common oral cavity pathogenic bacteria, dermatophyte, wound infection bacteria and the like, has the functions of promoting wound healing, diminishing inflammation and the like and provides a support for the application of the nitric oxide loaded cationic polymer in preparation of the biomedical engineering materials.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, in particular to a cationic polymer loaded with nitric oxide, a preparation method thereof and an application in the field of biomedicine. Background technique [0002] Since Furchgott discovered in 1980 that vascular endothelial cells can synthesize and secrete vascular endothelial-derived relaxation factor (EDRF), and proved that EDRF is NO in 1986, the basic and clinical research on NO has been vigorously developed. NO has become the most eye-catching biomolecule in recent years. [0003] In recent years, with the increasing number of clinically used antibacterial drugs, especially the widespread clinical application of many broad-spectrum antibiotics and new antibiotics, bacterial drug resistance has become the focus of global attention. For example, since penicillin was invented and used, antibiotics represented by penicillin have saved the lives of countless wounded patients...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G73/02C08G69/48A61K33/00A61K47/34A61P31/12A61P31/04A61P31/10A61P33/00
CPCA61K33/00A61K47/34C08G69/48C08G73/0206C08G81/00
Inventor 马栋张武李国巍薛巍
Owner JINAN UNIVERSITY
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