Cyclodextrin porous nanocapsule, and preparation method and use thereof

A technology of cyclodextrin and nanocapsules, which is applied in the field of medicine, can solve the problems of not being able to effectively obtain cyclodextrin polymers with regular morphology, restricting industrial production and application, etc., to facilitate industrial production and application, and improve biocompatibility Sexuality, the effect of simplifying the preparation process

Inactive Publication Date: 2014-11-12
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot effectively obtain cyclodextrin polymers with regular morphology and uniform distribution, which limits its potential industrial production and application to some extent.

Method used

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  • Cyclodextrin porous nanocapsule, and preparation method and use thereof
  • Cyclodextrin porous nanocapsule, and preparation method and use thereof
  • Cyclodextrin porous nanocapsule, and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Dissolve β-cyclodextrin (1g, 0.88mmol) in 5mL of 10% NaOH aqueous solution with a mass fraction of 10%. mmol), ultrasonic reaction for 5.5h. After the reaction, the pH of the solution was adjusted to neutral, the impurity was removed by dialysis, and finally freeze-dried to obtain 200 mg of cyclodextrin porous nanocapsules.

Embodiment 2

[0047] Dissolve β-cyclodextrin (1g, 0.88mmol) in 2mL of 21% NaOH aqueous solution at a temperature of 110°C, and slowly add glycerol triglycidyl ether (3.6g, 13.7mmol ), ultrasonic reaction for 25h. After the reaction, the pH of the solution was adjusted to neutral, the impurity was removed by dialysis, and finally lyophilized to obtain 250 mg of cyclodextrin porous nanocapsules.

Embodiment 3

[0049] Dissolve β-cyclodextrin (1g, 0.88mmol) in 15mL of 0.56% KOH aqueous solution, the water bath temperature is 20°C, and slowly add pentaerythritol tetraglycidyl ether (0.34g, 0.88mmol) under the ultrasonic power of 2000W , ultrasonic reaction 1h. After the reaction, the pH of the solution was adjusted to neutral, the impurity was removed by dialysis, and finally lyophilized to obtain 290 mg of cyclodextrin porous nanocapsules.

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Abstract

The invention relates to a method for preparing a cyclodextrin porous nanocapsule through ultrasonically initiated soap-free emulsion polymerization. The preparation method is characterized in that the cyclodextrin porous nanocapsule with regular morphology and uniform distribution is prepared by cross-linking cyclodextrin or its derivatives by a highly biocompatible cross-linking agent through using an ultrasonically initiated soap-free emulsion polymerization technology. The preparation method has the advantages of simplicity, easy implementation, one step reaction and environmental protection. The cyclodextrin porous nanocapsule prepared in the invention has good biocompatibility, inclusion ability, controlled release performance, identification ability, stability and chemical adjustability, so the cyclodextrin porous nanocapsule has potential industrial production and application values in many fields, such as a drug delivery system, pollutant adsorption, gas storage, food processing, cosmetics, and chemical separation and analysis. The invention also relates to an application of the cyclodextrin porous nanocapsule prepared through the method in the drug delivery system.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a cyclodextrin porous nanocapsule, its preparation method and its application. Background technique [0002] Cyclodextrin (Cyclodextrin, CD) is a series of cyclic oligosaccharides with varying degrees of polymerization formed by the action of starch by enzymes. It was first discovered by Villiers in 1891. Cyclodextrins have good biocompatibility and solubility, are nontoxic, readily available, and inexpensive. Common cyclodextrins are α-CD, β-CD and γ-CD, which are composed of 6, 7, and 8 D-glucopyranose units connected by α-1,4 glycosidic bonds, respectively. The molecular structure of cyclodextrin is in the shape of a "cone" with open ends and different diameters. The hydroxyl group at the C-6 position of the glucose unit is at the small diameter end, while the C-2 and C-3 hydroxyl groups are at the large diameter end. The inner cavity of cyclodextrin is hydrop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08K5/1515C08K5/3492C08K5/18A61K47/40B01J20/26A61K8/73
Inventor 韩宝航王有勍
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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